The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix [0.03%]
pentraxin-3的结构组织及其与间α抑制剂重链的相互作用调节透明质酸网状结构的交联反应
Anokhi Shah,Xiaoli Zhang,Matthew Snee et al.
Anokhi Shah et al.
Pentraxin-3 (PTX3) is an octameric protein, comprised of eight identical protomers, that has diverse functions in reproductive biology, innate immunity and cancer. PTX3 interacts with the large polysaccharide hyaluronan (HA) to which heavy ...
AGEing of collagen: The effects of glycation on collagen's stability, mechanics and assembly [0.03%]
糖基化对胶原稳定性和机械性能及装配的影响
Daniel Sloseris,Nancy R Forde
Daniel Sloseris
Advanced Glycation End Products (AGEs) are the end result of the irreversible, non-enzymatic glycation of proteins by reducing sugars. These chemical modifications accumulate with age and have been associated with various age-related and di...
Anticancer effect of a single-chain variable fragment against pro-matrix metalloproteinase-7 in colon cancer [0.03%]
抗促基质金属蛋白酶-7单链可变片段的抗结肠癌效应
Shinhye Min,Bohee Jang,Ji-Hye Yun et al.
Shinhye Min et al.
Disrupting the interaction between matrix metalloproteinase-7 (MMP-7) and syndecan-2 (SDC-2) can yield anticancer effects in colon cancer cells. Here, a single-chain variable fragment (scFv) targeting the pro-domain of MMP-7 was generated a...
Neurocan regulates axon initial segment organization and neuronal activity [0.03%]
神经粘连蛋白调控轴突初始段的组织结构及神经元活性
David Baidoe-Ansah,Hadi Mirzapourdelavar,Stepan Aleshin et al.
David Baidoe-Ansah et al.
The neural extracellular matrix (ECM) accumulates in the form of perineuronal nets (PNNs), particularly around fast-spiking GABAergic interneurons in the cortex and hippocampus, but also around synapses and in association with the axon init...
FGF and TGF-β Growth Factor Isoform Modulation of Human Gingival and Periodontal Ligament Fibroblast Wound Healing Phenotype [0.03%]
成纤维细胞生长因子和转化生长因子-β同种型调节人牙龈和牙周膜纤维母细胞的伤口愈合表型
Chengyu Guo,Amin S Rizkalla,Douglas W Hamilton
Chengyu Guo
Release of growth factors in the tissue microenvironment is a critical process in the repair and regeneration of periodontal tissues, regulating fibroblast behavior and phenotype. As a result of the complex architecture of the periodontium,...
35kDa SPECIFIC-SIZED HYALURONAN AMELIORATES HIGH-FAT DIET-INDUCED LIVER INJURY IN MURINE MODEL OF MODERATE OBESITY [0.03%]
35kDa特定分子量的透明质酸钠改善轻中度肥胖小鼠高脂饮食引起的肝脏损伤
Semanti Ray,Emily Huang,Megan R McMullen et al.
Semanti Ray et al.
Obesity is a growing concern in the US and world-wide, associated with an increased risk for several cardiometabolic diseases, including metabolic associated steatotic liver disease (MASLD). Currently, therapeutic interventions to prevent a...
Irene Torre-Cea,Patricia Berlana-Galán,Elena Guerra-Paes et al.
Irene Torre-Cea et al.
The lung is a highly vascularized tissue that often harbors metastases from various extrathoracic malignancies. Lung parenchyma consists of a complex network of alveolar epithelial cells and microvessels, structured within an architecture d...
Functional transfer of integrin co-receptor CD98hc by small extracellular vesicles improves wound healing in vivo [0.03%]
小型细胞外囊泡的功能转移可促进整合素共受体CD98hc在体内的伤口愈合功能
Floriane S Tissot,Soline Estrach,Laetitia Seguin et al.
Floriane S Tissot et al.
Extracellular vesicles (EVs) mediate intercellular communication. EVs are composed of a lipid bilayer and contain cytosolic proteins and RNAs. Studies highlight EVs striking functions in cell-cell crosstalk. Here, we found that small EVs ca...
Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease [0.03%]
软骨寡聚基质蛋白(COMP)的裂解产物与骨关节炎和其他退行性关节病相关的新表位生成
Rens de Groot,Patricia Badía Folgado,Kazuhiro Yamamoto et al.
Rens de Groot et al.
Osteoarthritis (OA) is a highly prevalent joint disease, affecting millions of people worldwide and characterized by degradation of articular cartilage, subchondral bone remodeling and low-grade inflammation, leading to pain, stiffness and ...
A CNA-35-based high-throughput fibrosis assay reveals ORAI1 as a regulator of collagen release from pancreatic stellate cells [0.03%]
一种基于CNA-35的高通量纤维化检测方法揭示出ORAI1能调节胰腺星形细胞胶原释放作用
Rieke Schleinhege,Ilka Neumann,Andrea Oeckinghaus et al.
Rieke Schleinhege et al.
Rationale: Pancreatic stellate cells (PSCs) produce a collagen-rich connective tissue in chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Ca2+-permeable ion channels such as ORAI1 are known to affect PSC ...