Dendrobine promotes osteogenesis-angiogenesis in postmenopausal osteoporosis by inhibiting Hippo signaling pathway [0.03%]
藤黄素通过抑制Hippo信号通路促进绝经后骨质疏松症的成骨和血管生成作用
Xiangping Meng,Xingtao Chen,Jin Huang
Xiangping Meng
Postmenopausal osteoporosis (PMOP) is a skeletal disorder marked by progressive bone mineral density decline and increased susceptibility to fractures. Accumulating evidence indicates that coupled osteogenesis and angiogenesis are indispens...
Modified citrus pectin modulates splenic immune responses and galectin expression following cisplatin treatment in Wistar rats [0.03%]
Modified citrus pectin可调节Wistar大鼠顺铂处理后的脾免疫反应和半乳糖凝集素表达
Diego Dias Dos Santos,Artur Francisco da Silva Neto,Laura Santana de Chiara et al.
Diego Dias Dos Santos et al.
Modified citrus pectin (MCP), a polysaccharide from citrus fruits, modulates galectin-3 (Gal-3) and immune responses. Although MCP exhibits notable immunomodulatory effects, its role in drug-induced splenic and systemic toxicity remains une...
CLEC14A mediates trophoblast dysfunction in unexplained miscarriage by disrupting the cAMP/ERK signaling pathway [0.03%]
CLEC14A通过破坏cAMP/ERK信号通路介导不明原因流产中的胎盘功能障碍
Jianing Wang,Yawei Shao,Linlin Zhou et al.
Jianing Wang et al.
Unexplained miscarriage (UM) is a distressing pregnancy disorder often associated with impaired trophoblast function. This study aimed to investigate the role of C-type lectin domain family 14 member A (CLEC14A) in the pathogenesis of UM an...
Immunohistochemical expression of pancreatic melatonin receptor (MTNR1B) under experimental sleep disturbance in rats [0.03%]
实验性睡眠障碍对大鼠胰腺褪黑素受体（MTNR1B）表达的影响
Salwa Hameed Affat,Huda Rashid Kamoona
Salwa Hameed Affat
Sleep amount and quality are important to maintain health, light exposure transported to the pineal gland via suprachiasmatic nucleus pineal pathway, and this affect melatonin synthesis. Melatonin exerts its action by receptors called MT1, ...
Xerophilusin B attenuates wear particle: associated osteolysis by inhibiting NF-κB signaling and restoring osteoblast-osteoclast coupling [0.03%]
Xerophilus in B通过抑制NF-κB信号传导并恢复成骨细胞破骨细胞偶联来缓解磨损颗粒相关性骨溶解作用
Hui Shi,Qian Meng,Tao Meng et al.
Hui Shi et al.
Periprosthetic osteolysis after total joint arthroplasty is the leading cause of aseptic loosening. Bone metabolic imbalance driven by aberrant NF-κB activation mediated by titanium wear particles is a central pathogenic mechanism. Availab...
Mechanistic insights into the neuroprotective effects of yangyin formula on cerebral ischemia-reperfusion injury via the IL-17A/MAPK/NF-κB signaling pathway [0.03%]
养阴法对脑缺血再灌注损伤神经保护作用的机制研究：通过IL-17A/MAPK/NF-κB信号通路
Kun Shi,Haofang Wan,Jin Han et al.
Kun Shi et al.
Ischemic stroke is a leading cerebrovascular disorder frequently complicated by cerebral ischemia-reperfusion injury (CIRI), which aggravates neurological damage and worsens clinical outcomes. Yangyin Formula (YYF), a traditional Chinese me...
Lidocaine alleviates diabetic neuropathic pain by inhibiting spinal astrocyte activation through modulation of the CXCL13/CXCR5 axis [0.03%]
利多卡因通过调节CXCL13/CXCR5轴抑制脊髓星形胶质细胞活化从而缓解糖尿病神经痛
QiaoZhen Liu,Hua Zhang
QiaoZhen Liu
This study aimed to investigate the analgesic effects of lidocaine (Lido) on diabetic neuropathic pain (DNP), a common complication of diabetes, and to elucidate the underlying mechanism. A DNP mouse model was established by a single strept...
Aquaporin-9 expression as an independent adverse prognostic marker in diffuse large B-cell lymphoma: an immunohistochemical tissue microarray study [0.03%]
血管维持蛋白-9在弥漫大B细胞淋巴瘤中的表达及其预后的免疫组织化学研究
Mayada Saad Farrag,Mohamed S Hemada,Salma Elashwah et al.
Mayada Saad Farrag et al.
Aquaporins (AQPs) are membrane channel proteins implicated in tumor biology, but their clinicopathological and prognostic relevance in diffuse large B-cell lymphoma (DLBCL) remains insufficiently characterized. This study evaluated the immu...
Multi-organ histological assessment of Agrococcus sp. RKDAS_1 reveals tissue-level biocompatibility in Oreochromis niloticus [0.03%]
模式鱼尼罗罗非鱼(Oreochromis niloticus)多器官组织水平生物相容性评估及放线菌Agrococcus sp. RKDAS_1的分类学研究
Venkatesan Karthick,Arun Venkatesh,Singamoorthy Amalraj et al.
Venkatesan Karthick et al.
A histological safety profile is essential for non-antibiotic microbial interventions in aquaculture. This study assessed the multi-organ histological biocompatibility of a novel actinobacterial strain, Agrococcus sp. RKDAS_1, in Nile tilap...
Estrogen promotes osteogenesis via YAP1-driven activation of ERα orchestrated through TEAD1 binding to the ERα promoter [0.03%]
雌激素通过TEAD1与ERα启动子结合促进YAP1驱动的ERα活化来促进成骨作用
Ruiying Han,Yikai He,Fushuang Liu et al.
Ruiying Han et al.