Rebamipide attenuates LPS-induced acute lung injury in rats via modulation of macrophage polarization, PDE4B/cAMP/PKA/p-CREB and NF-κB signaling [0.03%]
雷贝马替德通过调节巨噬细胞极化、PDE4B/cAMP/PKA/p-CREB和NF-κB信号减轻脂多糖诱导的大鼠急性肺损伤
Gellan Alaa Mohamed Kamel,Asmaa S Elzaitony,Abrar Gomaa Abd Elfattah Hassan et al.
Gellan Alaa Mohamed Kamel et al.
Acute lung injury (ALI) is a severe, potentially fatal condition associated with respiratory failure and high mortality, with limited effective therapeutic options. Rebamipide (REB), a gastroprotective agent with reported antioxidant and an...
The possible therapeutic effect of platelet-rich plasma versus its derived exosomes in a hydrogen peroxide-induced depigmentation model in adult guinea pigs: a histological study [0.03%]
富血小板血浆与其衍生的外泌体在氢氧化头发色素减退模型中可能的治疗效果：组织学研究
Ayat Fadel Hussieny,Seham Kamel Abounasef,Ghada Galal Hamam et al.
Ayat Fadel Hussieny et al.
Vitiligo is a pigmentary disorder characterized by the loss of functional melanocytes, leading to depigmented skin patches and significant psychological burden. Platelet-rich plasma (PRP) and its derived exosomes have recently gained attent...
HMGB1 promotes intracranial aneurysm progression by regulating vascular smooth muscle cell phenotypic switching and ferroptosis [0.03%]
HMGB1通过调节血管平滑肌细胞表型转换和铁死亡促进颅内动脉瘤进展
Huaxin Zhu,Yanyang Zeng,Zhipeng Xiao et al.
Huaxin Zhu et al.
Phenotypic switching in vascular smooth muscle cells (VSMCs) is key to the formation and progression of intracranial aneurysms (IAs). High-mobility group box 1 (HMGB1), a damage-associated molecule, significantly influences the progression ...
Cuscuta chinensis Lam. extract alleviates ovariectomy-induced osteoporosis by inhibiting VCP-mediated METTL3 protein degradation [0.03%]
Cuscuta chinensis Lam.提取物通过抑制VCP介导的METTL3蛋白降解来缓解卵巢切除术引起的骨质疏松症
Hua Jiang,Liangyu Ma,Yong Liu et al.
Hua Jiang et al.
To investigate the therapeutic effects of Cuscuta chinensis Lam. (CCL) on ovariectomy (OVX)-induced osteoporosis (OP) and elucidate the underlying molecular mechanisms, focusing on the VCP-METTL3 axis. The bioactive components of CCL were i...
Rosmanol alleviates glycerol-induced acute kidney injury through its antioxidative and anti-apoptotic properties via ameliorating the PGC‑1α/SIRT3 signalling pathway [0.03%]
罗丝曼醇通过改善PGC-1α/SIRT3信号通路的抗氧化和抗凋亡作用缓解甘油诱导的急性肾损伤
Huan Cheng,Jing Heng,Shiyue Liao et al.
Huan Cheng et al.
Acute kidney injury (AKI) represents a fatal complication of rhabdomyolysis, which is characterised by skeletal muscle damage and necrosis. Consequently, cell contents are released into the bloodstream, eventually obstructing renal tubules,...
LncRNA TUG1 promotes hypertrophic scar formation via the miR-627/IGF1R axis [0.03%]
长链非编码RNA TUG1通过miR-627/IGF1R轴促进增生性瘢痕形成
Zeming Bai,Ziyang Han,Xiangzi Kong et al.
Zeming Bai et al.
Hypertrophic scars (HS) are fibrotic skin disorders driven by abnormal fibroblast activity. The molecular mechanisms underlying HS remain incompletely understood, particularly the role of non-coding RNAs. Expression levels of lncRNA TUG1, m...
The ameliorate effect of 18-beta glycyrrhetinic acid against cadmium-induced reproductive damage [0.03%]
甘草酸改善镉致生殖损伤的作用研究进展
Osman Çiftçi,Münevver Nazlıcan Kaplan,Özlem Özmen et al.
Osman Çiftçi et al.
This study aimed to investigate whether 18β-glycyrrhetinic acid (GA) could protect against cadmium-induced testicular damage in male rats. Twenty-four adult male Sprague Dawley rats were randomly divided into four groups (n = 6): Control, ...
Baicalin-loaded chitosan hydrogel accelerates diabetic foot ulcer healing by regulating MAPK1 expression [0.03%]
载有拜尔可的壳聚糖水凝胶通过调节MAPK1表达促进糖尿病足溃疡愈合
Xuepu Zhang,Yue Zhang,Limin Yang et al.
Xuepu Zhang et al.
Diabetic foot ulcer (DFU) is a severe complication of diabetes. This study evaluated the effects and underlying mechanism of baicalin on DFU healing. High glucose (HG)-exposed HaCaT cells and streptozotocin-induced DFU rats were employed as...
Salidroside attenuates diabetic retinopathy by upregulating miR-142-3p to target TRAF6 [0.03%]
牻牛儿醇茋通过上调miR-142-3p靶向TRAF6缓解糖尿病视网膜病变
LiGuang Zhou,WeiQi Hang,Chao Li
LiGuang Zhou
This study aimed to investigate the role and molecular mechanisms of salidroside (SAL) in retinal vascular dysfunction under diabetic conditions. Human retinal microvascular endothelial cells (HRMECs) were cultured in a 30 mM high glucose (...
A novel histopathological insight: caspase-3 and Azan staining reveal placental malformations ameliorated by ethanolic extract of propolis in streptozotocin-induced diabetes during gestation [0.03%]
一种新颖的病理学见解：caspase-3和Azan染色揭示了乙醇型蜂胶提取物缓解链脲佐菌素诱导的妊娠糖尿病小鼠胎盘畸形的作用
Chahinez Boullouf,Leila Bouhafs,El Hadjela Derai et al.
Chahinez Boullouf et al.
Gestational diabetes mellitus is a common metabolic disorder of pregnancy associated with maternal metabolic disturbances, placental dysfunction, and adverse fetal outcomes. However, data on placental histopathological and apoptotic alterat...