NAT10-mediated ac4C acetylation of PKM2 promotes papillary thyroid carcinoma through regulating glycolysis [0.03%]
NAT10介导的PKM2的ac4C乙酰化通过调节糖酵解促进乳头状甲状腺癌的发展
Guobin Qiu,Yinghuan Cen,Yuan Li et al.
Guobin Qiu et al.
Papillary thyroid carcinoma (PTC) represents the most common histological variant among differentiated thyroid cancers. N4-acetylcytidine (ac4C) is a modified nucleoside in mRNA, which is essential for the regulation of mRNA stability. N-ac...
Guanxinshu attenuates atherosclerosis by suppressing Galectin-3-mediated NLRP3 inflammasome activation [0.03%]
关木通通过抑制半乳糖凝集素-3介导的NLRP3炎性小体活化来缓解动脉粥样硬化
Ruonan Wei,Zhongyi Zhu,Chunchun Zhao et al.
Ruonan Wei et al.
Atherosclerosis (AS) is a chronic inflammatory vascular disease strongly associated with the activation of the NLRP3 inflammasome. Studies have shown that Galectin-3 (Gal-3) promotes NOD-like receptor family pyrin domain-containing 3 (NLRP3...
MAGEA1 drives tumor progression via activation of the AKT pathway and correlates with elevated radiosensitivity in lung adenocarcinoma [0.03%]
MAGEA1通过激活AKT通路驱动肺腺癌肿瘤进展并与放疗敏感性升高相关
Fang Meng,Qi Zhu,Shiqiang Zhang
Fang Meng
Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Identifying novel molecular mechanisms underlying its progression and treatment resistance is crucial. MAGEA1, a cancer-testis antigen, exhibits oncogenic functions ...
MAGEA1 drives tumor progression via activation of the AKT pathway and correlates with elevated radiosensitivity in lung adenocarcinoma [0.03%]
MAGEA1通过激活AKT通路驱动肺癌腺癌进展并伴随放射敏感性升高
Fang Meng,Qi Zhu,Shiqiang Zhang
Fang Meng
Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Identifying novel molecular mechanisms underlying its progression and treatment resistance is crucial. MAGEA1, a cancer-testis antigen, exhibits oncogenic functions ...
Arginase 1 as a candidate immune-metabolic biomarker in lumbar disc herniation: integrated bioinformatics, experimental validation, and clinical evidence [0.03%]
精氨酸酶1作为腰椎间盘突出症免疫代谢标志物的候选标记物：生物信息学、实验验证和临床证据的整合研究
Qifeng Yao,Wei Shang,Mengdi Hu et al.
Qifeng Yao et al.
This study aimed to identify a candidate immune-related biomarker for lumbar disc herniation (LDH) and examine the functional relevance of ARG1 in intervertebral disc degeneration. Bioinformatics analysis was performed using the GSE146904 t...
Stage-dependent expression and nuclear localization of EZH2 in endometrial carcinogenesis: evidence from cell lines and human tissues [0.03%]
EZH2在子宫内膜癌变过程中表达及核定位的变化：来自细胞系和人组织的证据
Oya Korkmaz,Işıl Aydemir,Elgin Turkoz Uluer et al.
Oya Korkmaz et al.
Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator implicated in tumor progression; however, its expression pattern and subcellular localization across different stages of endometrial carcinogenesis remain incompletely charact...
Quercetin and hesperidin attenuate cyclophosphamide-induced renal injury in rats [0.03%]
槲皮素和hesperidin通过抗氧化应激和纤维化相关细胞因子减少环磷酰胺所致大鼠肾损伤
Şemsi Gül Yılmaz Kocaman,Serkan Yılmaz,Aslı Uçar
Şemsi Gül Yılmaz Kocaman
Cyclophosphamide (CP) is an effective chemotherapeutic agent whose clinical use is limited by nephrotoxicity associated with oxidative stress and inflammation. This study investigated the potential nephroprotective effects of quercetin (QUE...
Morphometric and immunohistochemical characterization of Rodlet cells in the kidney and liver of Gymnotus carapo [0.03%]
电鳗肾和肝Rodlet细胞的形态计量学和免疫组化特征分析
Eduen Gross,Gabriela Olea,Sabrina Méndez Galarza et al.
Eduen Gross et al.
Freshwater ecosystems are increasingly exposed to environmental stressors capable of inducing physiological and immunological alterations in aquatic organisms. In this context, fish are widely recognized as valuable bioindicators because th...
Ferroptosis induction by curcumin through regulating the expression of glutathione peroxidase 4 in papillary thyroid carcinoma [0.03%]
姜黄素通过调节谷胱甘肽过氧化物酶4表达诱导乳头状甲状腺癌细胞铁死亡
Li Ren,Haofeng Ding,Yun Sun et al.
Li Ren et al.
To clarify the role of glutathione peroxidase 4 (GPX4)-mediated ferroptosis in curcumin-treated papillary thyroid carcinoma (PTC) cells and explore the underlying mechanisms. GPX4 expression and clinical relevance were analysed in 54 PTC ti...
The role of the HB-EGF-regulated EGFR-mitophagy axis in maintaining cartilage homeostasis and osteoarthritis [0.03%]
HB-EGF调控的EGFR线粒体自噬轴在软骨稳态及骨关节炎中的作用
JunHua Wang,ChiShou Mo,Qiang Wang et al.
JunHua Wang et al.
This study investigates the mechanism by which heparin-binding epidermal growth factor (HB-EGF) maintains cartilage homeostasis in osteoarthritis (OA) through the epidermal growth factor receptor (EGFR)-mitochondrial autophagy axis. Given t...