Integrated UPLC-MS/MS profiling and network pharmacology-based analysis of the anti-hyperglycemic potential of Baihu Jia Renshen Decoction combined with Sanghuangporus vaninii extract in mice [0.03%]
基于整合型UPLC-MS/MS分析和网络药理学分析的白虎加人参汤联合桑黄提取物降糖潜力的评价研究
Jia Zhang,Ying Chen,Yanfa Lin et al.
Jia Zhang et al.
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder requiring multi-target therapeutic strategies. Traditional Chinese medicine offers potential multi-component interventions, yet the material basis and molecular mechanisms of n...
Prophylactic administration of silica nanoparticles loaded with amifostine prevents cisplatin-induced nephrotoxicity in rats [0.03%]
载氨磷汀的二氧化硅纳米颗粒预防顺铂致大鼠肾毒性的效果研究
Rehab A Mohamed,Nadia A Mohamed,Dawoud F Habib et al.
Rehab A Mohamed et al.
Drug-induced nephrotoxicity is a major limitation in chemotherapy, particularly with cisplatin, necessitating effective renal-protective strategies. Amifostine, a thiol-based prophylactic agent, has potential to mitigate such toxicity. This...
Syntaxin-4, a key exocytosis mediating protein, shows heterogeneous expression in insulin-positive cells of human donors with new-onset and longer duration of type 1 diabetes: comparison with non-diabetic autoantibody-positive and -negative donors [0.03%]
syntaxin-4在新发及较长病程的1型糖尿病人胰岛中阳性细胞中的异质表达：与自身抗体阳性和阴性对照组比较
Joshua Potman,Kevin Xueying Sun,Kaaj Pala et al.
Joshua Potman et al.
Syntaxin-4, a beta cell plasma membrane-anchored protein, attaches to beta cell granules with two spatially-located nearby proteins, facilitating the fusion of beta cell-docked granules to the plasma membrane, followed by exocytotic release...
Effect of long-term use of very low-carbohydrate Ketogenic diet on the thyroid gland and adipose tissue of adult male albino rats (biochemical and histological study) [0.03%]
长期使用极低碳水化合物生酮饮食对成年雄性白鼠甲状腺和脂肪组织的影响（生物化学和组织学研究）
Randa Ahmed Ibrahim,Nehal Mohammed Elwaddah,Neven Makram Aziz et al.
Randa Ahmed Ibrahim et al.
Ketogenic diet (KD) therapy is a high-fat, low-carbohydrate, low-protein diet with a macronutrient ratio of 89% fat, 10% protein, and 1% carbohydrates. This causes the body's primary energy source to shift to lipids. Improved glycemic contr...
Celastrol attenuates synovial inflammation and experimental arthritis by modulating PTGS2-associated ferroptosis resistance in fibroblast-like synoviocytes [0.03%]
Celastrol通过调节滑膜细胞中铁死亡抗性相关基因PTGS2的表达来抑制滑膜炎症和实验性关节炎的作用机制研究
Yunke Guo,Hao Tang,Zulayat Ablikim et al.
Yunke Guo et al.
Rheumatoid arthritis (RA) is characterized by persistent synovial inflammation and aggressive activation of fibroblast-like synoviocytes (FLS). Celastrol has recognized anti-inflammatory activity, but its mechanism in RA remains incompletel...
Autophagy dysfunction in pancreatic acinar cells in acute pancreatitis: from molecular mechinery and trypsinogen activation to heterogeneity and therapeutic implications [0.03%]
急性胰腺炎中胰腺外分泌细胞自噬功能障碍：从分子机制及胰蛋白酶原激活到异质性和治疗意义
Yuping Feng,Wen Guo,Rui Wu et al.
Yuping Feng et al.
Acute pancreatitis (AP) is a common acute and critical disease of the digestive system. The initial step of its pathogenesis is the abnormal activation of trypsinogen within pancreatic acinar cells. Seminal studies have identified autophagy...
Electroacupuncture confers neuroprotection against ischemic stroke via the DNA methylation-RhoGDIα axis [0.03%]
电针通过DNA甲基化-RhoGDIα轴对缺血性中风发挥神经保护作用
Xiaoli Min,Qing Zhao,Xiaohong Zhao et al.
Xiaoli Min et al.
Electroacupuncture (EA) has emerged as a promising alternative therapy for ischemic brain injury, yet its underlying molecular mechanisms remain incompletely understood. This study investigated the neuroprotective effects and epigenetic mec...
SOX9 knockdown alleviates Aβ1‑42‑induced neuroinflammation by regulating microglial polarization via inactivation of the ASK1/JNK signaling pathway [0.03%]
SOX9敲低通过使ASK1/JNK信号通路失活调节小胶质细胞极化从而缓解Aβ1-42诱导的神经炎症
Minghui Zheng,Bingxu Hou,Ruxue Ma et al.
Minghui Zheng et al.
Neuroinflammation driven by microglial polarization imbalance plays a key role in Aβ-induced neuronal injury, a core pathological feature of Alzheimer's disease (AD). The transcription factor SOX9 has been linked to AD progression, but its...
LncRNA MNX1-AS1 drives the progression of non-small cell lung cancer and serves as a ceRNA to target COMMD8 by sponging miR-218-5p [0.03%]
长链非编码RNA MNX1-AS1通过海绵吸附miR-218-5p调控COMMD8促进非小细胞肺癌进展并作为竞争性内源RNA的作用机制研究
Gao-Feng Liu,Li Zhou,Yu-Bo Zhao et al.
Gao-Feng Liu et al.
The role and mechanistic action of MNX1-AS1 in non-small cell lung cancer (NSCLC) remain unclear. This study aimed to investigate the function of MNX1-AS1 in the progression of NSCLC. A total of 40 paired tumor and adjacent lung tissue samp...
Neuroprotective effects of zingerone on the thioacetamide-induced hepatic encephalopathy in rats. Insights from oxidative stress, ER stress, BDNF signaling and apoptosis [0.03%]
姜辣素通过抗氧化、抗内质网应激、上调脑源性神经营养因子信号及抑制细胞凋亡对硫乙醇酸致大鼠肝性脑病的神经保护作用：来自氧化应激、内质网应激、BDNF信号通路和细胞 apoptosis 的见解
Furkan Aykurt,Serkan Yildirim,Metin Kİlİçlİoğlu et al.
Furkan Aykurt et al.
This study investigated the protective effects of zingerone (ZIN) against thioacetamide (TAA)-induced hepatic encephalopathy (HE) in rats (n = 10 per group). HE was induced by TAA (200 mg/kg, intraperitoneally (i.p.)) on days 1 and 3, and r...