Xerophilusin B attenuates wear particle: associated osteolysis by inhibiting NF-κB signaling and restoring osteoblast-osteoclast coupling
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Periprosthetic osteolysis after total joint arthroplasty is the leading cause of aseptic loosening. Bone metabolic imbalance driven by aberrant NF-κB activation mediated by titanium wear particles is a central pathogenic mechanism. Available therapies have cl... ...
