EXPRESS: Endothelial expression of human soluble epoxide hydrolase worsens acute microvascular and tissue injury after stroke in female mice with early-stage diabetes mellitus [0.03%]
糖尿病女性小鼠中内皮细胞表达的人可溶性环氧化物水解酶加重卒中的微血管和组织损伤
Wenbin Zhu,Robert E Shangraw,Catherine Davis et al.
Wenbin Zhu et al.
Female mice are protected from diabetes mellitus type 2 (DM2)-exacerbation of ischemic brain injury, concurrently expressing less soluble epoxide hydrolase (sEH), which degrades neuroprotective epoxyeicosatrienoates (EETs). We hypothesize t...
EXPRESS: Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC [0.03%]
功能MRS揭示了情绪认知参与过程中大脑乳酸动力学的年龄相关变化，表明dACC代谢易感性
Edward Caddye,Joel Patchitt,Anouk Schrantee et al.
Edward Caddye et al.
BackgroundThe dorsal anterior cingulate cortex (dACC), a glycolytically active region implicated in psychiatric disorders, shows lactate dynamics that may respond to cognitive-emotional demand. Aging, with its decline in mitochondrial funct...
EXPRESS: Parvalbumin interneurons contribute to spontaneous hemodynamic fluctuations [0.03%]
简报： parvalbumin阳性中间神经元贡献自发性血流波动
Adiya Rakymzhan,Mitsuhiro Fukuda,Alberto Vazquez
Adiya Rakymzhan
Resting-state hemodynamic fluctuations take place over broad temporal scales and are reported to be closely linked to gamma-band neural activity, yet whether specific cell types drive these fluctuations remains unclear. Given the establishe...
EXPRESS: Ultrasound Enhances Glymphatic-Associated Solute Transport via Piezo1-Related Mechanotransduction in 5xFAD Mice [0.03%]
小鼠5xFAD小鼠中，超声波通过Piezo1相关的力学信号转导增强胶淋巴介导的溶质转运
Li Zhang,Kang He,Han Zhang et al.
Li Zhang et al.
Background: Glymphatic dysfunction impairs Aβ clearance and contributes to Alzheimer's disease (AD) progression. Low-intensity transcranial focused ultrasound (LITFUS) can enhance glymphatic cerebrospinal fluid transport...
EXPRESS: It's not all rapid dilations: on contributions of constrictions, biphasic and minute-long vessel responses to brain functional hyperemia [0.03%]
简报：不只是快速扩张：论收缩、双相和长达一分钟的血管反应对脑功能性血管舒张的贡献
Matthew Rozak,Adrienne Dorr,Emma Pineau et al.
Matthew Rozak et al.
Though neurovascular coupling has long been studied, a comprehensive characterization of the extent, kinetics, and variability of individual microvessels' responses is lacking. To address this, we employed our NOVAS3D deep learning pipeline...
EXPRESS: Therapeutic Hypothermia Via Hypothalamic Neuromodulation: A New Approach for Stroke Brain Protection [0.03%]
通过下丘脑神经调控的治疗性低温：中风脑保护的新方法
Shuai Zhang,Qiang-Rong Huang,Donghai Li et al.
Shuai Zhang et al.
Stroke continues to be a leading cause of death and long-term neurological disability globally, with current treatment options limited by narrow time windows and insufficient neuroprotective strategies. Over recent decades, research into ef...
EXPRESS: Endothelial estrogen receptor alpha (ESR1) regulates cerebral cavernous malformation pathogenesis via MEKK3-KLF signalling pathway [0.03%]
内皮细胞雌激素受体α（ESR1）通过MEKK3-KLF信号通路调节脑海绵状血管畸形的发病机制
Hamidreza Sadegh,Liwenyu Chen,Suyun Yu et al.
Hamidreza Sadegh et al.
Cerebral cavernous malformations (CCMs) are common brain hemangioma that can occur sporadically or be inherited. CCM is one of the major causes of hemorrhagic stroke and neurological deficits in children. There are no pharmacological treatm...
EXPRESS: The Role and Mechanism of Lysyl Hydroxylase 1 (LH1) in Vascular Lesions in Hypertensive Intracerebral Hemorrhage [0.03%]
Lysyl Hydroxylase 1在高血压性脑出血血管病变中的作用及机制研究
Haochen Xu,Yue Guo,Hongyan Wen et al.
Haochen Xu et al.
Background: Hypertensive intracerebral hemorrhage (ICH) is a common stroke subtype, with high disability and mortality rates. Its onset and progression are associated with structural abnormalities and vascular wall remode...
Brain barriers as checkpoints in endocrine regulation of body homeostasis [0.03%]
脑屏障在内分泌调节机体稳态中的作用检查点
Da Young Kang,Min Joung Lee,Sumin Kim et al.
Da Young Kang et al.
The hypothalamic-pituitary-adrenal (HPA) axis has long served as a classical model of brain-body communication, illustrating how neuroendocrine signaling maintains physiological homeostasis. While endocrine hormones have traditionally been ...
Ferroptosis of microvascular pericytes contributes to ischemia-reperfusion injury in mice [0.03%]
小胶质细胞铁死亡在缺血再灌注损伤中的作用
Hayato Takaki,Kuniyuki Nakamura,Masamitsu Takashima et al.
Hayato Takaki et al.
Ferroptosis is an iron-dependent form of programmed cell death implicated in various pathological conditions. We investigated whether ferroptosis contributes to acute ischemic stroke using a transient middle cerebral artery occlusion model ...