Simultaneous measurement of water transport across the blood-brain and blood-CSF barrier in the human brain with arterial spin labeling MRI [0.03%]
Léonie Petitclerc,Helena Durrant,Lydiane Hirschler et al.
Léonie Petitclerc et al.
Previously, water exchange across the blood-brain barrier (BBB) and blood-cerebrospinal barrier (BCSFB) was assessed by multi-delay, multi-echotime (TE) arterial spin labeling, albeit in separate acquisitions with different settings. In thi...
Sunghee Cho,Hyunwoo Ju
Sunghee Cho
Following a central nervous system (CNS) injury including stroke, inflammation is a complex but crucial part of the body's response. Although the extent of inflammation correlates with stroke severity, anti-inflammatory drugs have shown lim...
A reference-based PET/MRI method for quantifying activation-induced changes in cerebral oxygen metabolism [0.03%]
Graham Deller,Linshan Liu,Justin W Hicks et al.
Graham Deller et al.
Hybrid PET/MRI can overcome the complexity of PET imaging of the cerebral metabolic rate of oxygen (CMRO2), while retaining the ability to directly measure oxygen uptake in the brain. One technique, PMROx, incorporates complementary MRI met...
Peripheral RIPK2 degradation improves neurological outcomes after experimental ischemic stroke [0.03%]
John Aaron Howell,Jonathan Larochelle,Mia Strawser et al.
John Aaron Howell et al.
Receptor-interacting serine/threonine kinase 2 (RIPK2) is an important modulator of the inflammatory response in many disease states, including ischemic stroke. Here, we utilized, for the first time, a proteolysis targeting chimera (PROTAC)...
High-temporal resolution metabolic connectivity resolved by component-based noise correction [0.03%]
Murray B Reed,Samantha Graf,Matej Murgaš et al.
Murray B Reed et al.
Recent advances in functional PET (fPET) enable modeling of metabolic processes with second-level temporal resolution, opening applications such as imaging molecular connectivity comparable to fMRI. However, high-temporal fPET is more noise...
High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER [0.03%]
Saloni Mehta,Huili Sun,Nicola Micali et al.
Saloni Mehta et al.
The NeuroEXPLORER (NX), a next generation brain-dedicated PET scanner, has demonstrated improved spatial resolution and sensitivity compared with previous PET scanners. In this study, we performed synaptic vesicle glycoprotein 2A (SV2A) PET...
Eriko Furube,Yusuke Tanaka,Shigetaka Yoshida et al.
Eriko Furube et al.
Circumventricular organs (CVOs), exemplified by the area postrema (AP), lack a classical blood-brain barrier (BBB) and feature expanded perivascular spaces (PVS) that support neuroimmune communication. Yet the precise localization of immune...
Protective and pathogenic: The Janus-faced role of cGAS-STING in the brain [0.03%]
保护与致病：cGAS-STING在脑中的双面作用
Carlo Corona,Christina Kanzlemar,Abid Hussaini et al.
Carlo Corona et al.
Innate immune signaling preserves brain integrity during infection and sterile injury but can also drive neurodegeneration and cognitive decline. Over the past 2 decades, work has shown that cytosolic DNA sensing via the cGAS-STING pathway ...
Unveiling m7G modification patterns and causal drivers governing intracranial aneurysm rupture risk through multi-omics validation and m7G-MeRIP-seq profiling [0.03%]
通过多组学验证和m7G-MeRIP-seq谱分析揭示m7G修饰模式及支配颅内动脉瘤破裂风险的因果驱动因素
Pengfei Wu,Aierpati Maimaiti,Zekun Ma et al.
Pengfei Wu et al.
Intracranial aneurysm (IA) rupture causes severe brain hemorrhage with high mortality, yet its molecular drivers remain unclear and better risk prediction is urgently needed. Using transcriptomics, single-cell analysis, and genetic data, we...