EXPRESS: It's not all rapid dilations: on contributions of constrictions, biphasic and minute-long vessel responses to brain functional hyperemia [0.03%]
简报：不只是快速扩张：论收缩、双相和长达一分钟的血管反应对脑功能性血管舒张的贡献
Matthew Rozak,Adrienne Dorr,Emma Pineau et al.
Matthew Rozak et al.
Though neurovascular coupling has long been studied, a comprehensive characterization of the extent, kinetics, and variability of individual microvessels' responses is lacking. To address this, we employed our NOVAS3D deep learning pipeline...
EXPRESS: Therapeutic Hypothermia Via Hypothalamic Neuromodulation: A New Approach for Stroke Brain Protection [0.03%]
通过下丘脑神经调控的治疗性低温：中风脑保护的新方法
Shuai Zhang,Qiang-Rong Huang,Donghai Li et al.
Shuai Zhang et al.
Stroke continues to be a leading cause of death and long-term neurological disability globally, with current treatment options limited by narrow time windows and insufficient neuroprotective strategies. Over recent decades, research into ef...
EXPRESS: Endothelial estrogen receptor alpha (ESR1) regulates cerebral cavernous malformation pathogenesis via MEKK3-KLF signalling pathway [0.03%]
内皮细胞雌激素受体α（ESR1）通过MEKK3-KLF信号通路调节脑海绵状血管畸形的发病机制
Hamidreza Sadegh,Liwenyu Chen,Suyun Yu et al.
Hamidreza Sadegh et al.
Cerebral cavernous malformations (CCMs) are common brain hemangioma that can occur sporadically or be inherited. CCM is one of the major causes of hemorrhagic stroke and neurological deficits in children. There are no pharmacological treatm...
EXPRESS: The Role and Mechanism of Lysyl Hydroxylase 1 (LH1) in Vascular Lesions in Hypertensive Intracerebral Hemorrhage [0.03%]
Lysyl Hydroxylase 1在高血压性脑出血血管病变中的作用及机制研究
Haochen Xu,Yue Guo,Hongyan Wen et al.
Haochen Xu et al.
Background: Hypertensive intracerebral hemorrhage (ICH) is a common stroke subtype, with high disability and mortality rates. Its onset and progression are associated with structural abnormalities and vascular wall remode...
Brain barriers as checkpoints in endocrine regulation of body homeostasis [0.03%]
脑屏障在内分泌调节机体稳态中的作用检查点
Da Young Kang,Min Joung Lee,Sumin Kim et al.
Da Young Kang et al.
The hypothalamic-pituitary-adrenal (HPA) axis has long served as a classical model of brain-body communication, illustrating how neuroendocrine signaling maintains physiological homeostasis. While endocrine hormones have traditionally been ...
Ferroptosis of microvascular pericytes contributes to ischemia-reperfusion injury in mice [0.03%]
小胶质细胞铁死亡在缺血再灌注损伤中的作用
Hayato Takaki,Kuniyuki Nakamura,Masamitsu Takashima et al.
Hayato Takaki et al.
Ferroptosis is an iron-dependent form of programmed cell death implicated in various pathological conditions. We investigated whether ferroptosis contributes to acute ischemic stroke using a transient middle cerebral artery occlusion model ...
EXPRESS: Post-Ischemic Sodium Glucose Cotransporter Inhibition Attenuates Ischemia-Reperfusion Injury via Regulation of Mitochondrial Membrane Potential [0.03%]
缺血再灌注损伤的新型抑制剂：钠葡萄糖共转运蛋白抑制剂通过调节线粒体膜电位起作用
Tomoya Okamaoto,Hiromitsu Sasaki,Yudai Morisaki et al.
Tomoya Okamaoto et al.
Purpose: Ischemia-reperfusion injury remains a major clinical challenge even after successful recanalization in stroke patients. Mitochondrial membrane potential plays a key role in the neuroprotective effect against isch...
EXPRESS: Glymphatic System Dysfunction and Neurological Disorders: From Mechanisms to Therapeutic Strategies [0.03%]
淋巴系统功能障碍与神经系统疾病：从机制到治疗策略
Zinan Guo,Mengying Dai,Shuo Song et al.
Zinan Guo et al.
Traditional neuroanatomy long asserted the absence of lymphatic circulation in the central nervous system, contradicting its high metabolic activity and efficient waste removal. This paradox was resolved in the 21st century by Iliff et al.,...
EXPRESS: Toll Like Receptor 4 (TLR4) in Neuroinflammation: From Acute Hemorrhagic Stroke to Chronic Neurodegeneration [0.03%]
髓样分化因子2和 toll 样受体4在脑缺血中的作用及机制研究进展
Hadi Hasan Choudhary,Jun Yoshida,Rezwanul Islam et al.
Hadi Hasan Choudhary et al.
Subarachnoid Hemorrhage (SAH) remains a leading cause of morbidity and mortality worldwide. While the primary injury is defined by mechanical tissue disruption, the progression of secondary brain injury is largely driven by robust neuroinfl...
EXPRESS: Ventricular CSF-to-blood water transport kinetics in adult hydrocephalus [0.03%]
成人脑积水的脑脊液-血液转运动力学研究
Per Kristian Eide,Alexander Gul Sherwani,Luis Romundstad et al.
Per Kristian Eide et al.
Water exchange between cerebrospinal fluid (CSF) and blood is fundamental to brain fluid homeostasis, yet ventricular CSF-to-blood water transport has never been quantified as a physiological parameter in adult humans. We investigated ventr...