Research progress and clinical translation challenges in the use of oncolytic bacteria for cancer therapy [0.03%]
溶瘤细菌癌症治疗的研究进展及其临床转化挑战
Min Lu,Zhimin Sun,Yimin Qian et al.
Min Lu et al.
Oncolytic bacteria represent a distinct group of microorganisms capable of selectively infecting and colonizing tumor tissues while sparing normal cells. They exert anti-tumor effects primarily by activating the host immune system and elici...
Arezu Karimpur-Zahmatkesh,Mohammad Khalaj-Kondori
Arezu Karimpur-Zahmatkesh
Increased recurrence risk, aggressiveness, metastasis, and poor prognosis of cancer disease are challenges of conventional cancer treatment strategies attributed to cancer stem cells (CSCs). These cells are primarily defined as a small numb...
Merremia tridentata ethyl acetate extract suppresses HepG2 hepatocellular carcinoma cell proliferation via PCNA downregulation and mitochondria-mediated apoptosis [0.03%]
三叶兔葵乙酸萃取物通过下调PCNA和线粒体介导的凋亡抑制HepG2肝癌细胞增殖
Kiruthika Kasthuri,Vijayalakshmi Kumaravel,Madan Kumar Arumugam
Kiruthika Kasthuri
Merremia tridentata of the Convolvulaceae family exhibits multiple therapeutic properties and is commonly utilized in ethnomedicine. The anti-cancerous property of M. tridentata ethyl acetate extract (MtEAE) was evaluated in HepG2 hepatocel...
Retraction Note: The physician payments sunshine act and medical oncology: a seven-year financial analysis [0.03%]
撤回：《阳光法案与医学肿瘤学：七年财务分析》
Xiyu Zhao,Victor Yang,Mohammed Ullah et al.
Xiyu Zhao et al.
Evaluation of the anticancer effects of ellagic acid and cisplatin in cisplatin-sensitive and -resistant MDA-MB-231 breast cancer cells [0.03%]
评估鞣酸和顺铂在顺铂敏感和耐药的MDA-MB-231乳腺癌细胞中的抗癌效果
Gamze Turna Saltoglu,Serap Yalcın Azarkan,Gulistan Sanem Sarıbas et al.
Gamze Turna Saltoglu et al.
Ellagic acid (EA) is a natural polyphenol noted for its antiproliferative and pro-apoptotic effects. This study investigates the impact of EA, alone or combined with cisplatin (CIS), on the expression of angiogenesis, apoptosis, metastasis,...
ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer [0.03%]
ULK1调控的自噬改变三阴性乳腺癌促肿瘤通路
Merve Gulsen Bal Albayrak,Sevinc Yanar,Tuğcan Korak et al.
Merve Gulsen Bal Albayrak et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapies and poor prognosis. Unc-51-like kinase 1 (ULK1), a central regulator of autophagy, has emerged as a potential therapeutic node in cancer but remai...
Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis [0.03%]
人类T细胞病毒和BLV利用CREB信号通路的机制：病毒持久感染及白血病发生的轴心
Zahra Farjami,Mohammad Mehdi Akbarin
Zahra Farjami
Deltaretroviruses, including Human T-cell Leukemia Virus type 1 (HTLV-1) and Bovine Leukemia Virus (BLV), are oncogenic pathogens that exploit host transcriptional machinery to establish persistence and drive malignant transformation. Centr...
Piperine-induced AMPK activation and cell cycle arrest: insights from molecular simulations and experimental validation in breast cancer [0.03%]
毕柏林通过分子模拟和实验验证激活AMPK并导致乳腺癌细胞周期停滞
Ifat Jan,Tabasum Ali,Rafat Ali et al.
Ifat Jan et al.
Breast cancer remains a leading cause of mortality among women, underscoring the need for novel, low-toxicity therapeutic strategies. Piperine, a bioactive alkaloid derived from Piper nigrum, has shown promising anticancer activity; however...
Therapeutic exploration of combined local hyperthermia and anti-CD200 blockade therapy in the EMT6 breast cancer model [0.03%]
联合局部热疗和抗CD200阻断疗法在EMT6乳腺癌模型中的治疗探索
Wan Fatin Amira Wan Mohd Zawawi,Kar Min Loh,Asnida Abdul Wahab et al.
Wan Fatin Amira Wan Mohd Zawawi et al.
Breast cancer remains the leading cause of cancer-related deaths among women worldwide. Combinatorial therapies are often employed to improve treatment efficacy and reduce the risk of recurrence. Hyperthermia (HT), a minimally invasive trea...
FN1 as a key gene in modulating the integrin cell surface pathway in breast cancer [0.03%]
FN1作为乳腺癌中调控整合素细胞表面途径的关键基因
Mahboubeh Sadeghi,Abbas Ghaderi,Pegah Mousavi et al.
Mahboubeh Sadeghi et al.
Breast carcinoma represents the most prevalent form of invasive neoplasia among the female population globally, and is distinguished by its molecular heterogeneity by significant genomic instability. The discipline of bioinformatics provide...