Phytochemicals remodel antitumor immunity via the "microbiota-metabolite-receptor" axis: focus on colorectal cancer and immunotherapy [0.03%]
植物化学物质通过“微生物群-代谢物-受体”轴重塑抗肿瘤免疫：重点关注结直肠癌和免疫治疗
Xueyi Qin,Guichen Huang,Ying Han et al.
Xueyi Qin et al.
Colorectal cancer (CRC) is a malignancy with high mortality. Due to the suppressive state of the tumor immune microenvironment (TIME), approximately 95% of microsatellite-stable (MSS) or proficient mismatch repair (pMMR) cases exhibit poor ...
Combinatorial cancer therapy mediated by hydroxyapatite nanoparticles: a comprehensive review [0.03%]
羟基磷灰石纳米颗粒介导的联合癌症治疗：全面综述
Khadija Fatima,Iqra Fatima Khan,Sidra Fatima Khan et al.
Khadija Fatima et al.
Hydroxyapatite nanoparticles (HANPs) have emerged as versatile and biocompatible platforms in cancer nanomedicine, offering multifunctional roles in drug delivery, imaging, and combinatorial therapy. Their structural similarity to bone apat...
IFITM3 promotes an M2-like tumor-supportive microenvironment in acute myeloid leukemia [0.03%]
IFITM3促进急性髓系白血病中的M2型肿瘤支持性微环境
Fang Zhou,Yi Zhang,JiaHeng Guan et al.
Fang Zhou et al.
Interferon-induced transmembrane protein 3 (IFITM3) is overexpressed in acute myeloid leukemia (AML) and is associated with poor prognosis. Previous studies implicate IFITM3 in oncogenic processes and immune modulation; however, the mechani...
Liposomal honokiol attenuates dimethylhydrazine-induced colon carcinogenesis in rats through modulation of oxidative stress, inflammation, apoptosis, autophagy, and lipid metabolism pathways [0.03%]
脂质体Honokiol通过调节氧化应激、炎症、凋亡、自噬和脂质代谢途径来缓解二甲基肼诱导的大鼠结肠癌变
Shahad W Kattan,Amany I Almars,Ekramy M Elmorsy et al.
Shahad W Kattan et al.
Colorectal cancer is one of the leading causes of cancer-related mortality worldwide, and its progression is strongly associated with oxidative stress, chronic inflammation, dysregulated apoptosis, and impaired autophagy. Although honokiol ...
Identification of a lncRNA prognostic signature reveals that SNAI3-AS1 cooperates with erastin to reshape macrophage polarization in glioma [0.03%]
鉴定长链非编码RNA预后标志物发现SNAI3-AS1通过与Erastin协同作用重塑胶质瘤相关巨噬细胞极化的新机制
Xiaochen Niu,Aijie Guo,Yifan Wang et al.
Xiaochen Niu et al.
Glioma progression is heavily driven by heterogeneity and a highly immunosuppressive tumor microenvironment (TME). This study aimed to identify a robust long non-coding RNA (lncRNA) prognostic signature and elucidate its role in TME remodel...
Effects of Astragalus membranaceus injection at Zusanli (ST36) acupoint on lung cancer with COPD [0.03%]
黄芪注射液佐足三里对肺癌合并慢阻肺的影响
Yiting Zheng,Chenran Xu,Tiefeng Zhu et al.
Yiting Zheng et al.
This study investigates the antitumor effects and immunomodulatory mechanisms of Astragalus membranaceus (AM) injection at Zusanli (ST36) acupoint in a mouse model of lung cancer with chronic obstructive pulmonary disease (LC-COPD). Mice we...
Nanomedicine-based sensitization and resistance reversal in immunotherapy of clear cell renal cell carcinoma: from tumor microenvironment to precision delivery [0.03%]
基于纳米医学的免疫治疗透明细胞肾细胞癌中的敏化和耐药逆转：从肿瘤微环境到精准递送
Jinhu Ma,Ziyang Qiang,Wenhao Xie et al.
Jinhu Ma et al.
Clear cell renal cell carcinoma poses unique challenges for immunotherapy, particularly with immune checkpoint inhibitors. Many ccRCC tumors exhibit an "immune-cold" tumor immunosuppressive microenvironment (TIME), characterized by poor T c...
Vikesh Kumar Shukla,Akshma Chauhan,Krishnajit Malakar et al.
Vikesh Kumar Shukla et al.
Expedited regulatory approval pathways are vital for providing timely patient access to novel therapies in oncology and other serious conditions. The traditional drug development pathway can take significant time, substantial costs (often m...
Disulfidptosis and its molecular mechanisms in cancer: mechanisms, regulation, and therapeutic potential [0.03%]
癌症中的二硫键脱落及其分子机制：机制、调控和治疗潜力
Zhenlong Zhou,Haichun Zhou
Zhenlong Zhou
Disulfidptosis is a novel form of programmed cell death. It is triggered by metabolic and redox imbalance. It is executed through the irreversible collapse of the actin cytoskeleton. Its core mechanism involves the 'SLC7A11-cystine-NADPH-ac...
DC-intrinsic SHP1 restrains central memory CD8⁺ T cell formation via the TCF-1/Wnt/β-Catenin axis [0.03%]
内源性SHP1通过TCF-1/Wnt/β-Catenin轴抑制中央记忆CD8+T细胞的形成
Bing Li,Huilin Lu,Jiayi Huang et al.
Bing Li et al.
The tumor microenvironment (TME) limits durable antitumor immunity by impairing CD8+ T cell responses. Memory like CD8+ T cells are important for long-term immune control but are often restricted in the TME. Dendritic cells (DCs) are key re...