Investigation of the effect of encapsulating cisplatin with the active compound silibinin in PLGA polymeric nanoparticles on the HeLa cervical cancer cell line [0.03%]
含有活性成分异鼠李素的PLGA聚合物纳米粒包封顺铂对HeLa宫颈癌细胞系的影响研究
Parinaz Akbari,Hameed A Ali,Mohammad Negahi et al.
Parinaz Akbari et al.
Cisplatin remains one of the most widely used chemotherapeutic agents, yet its clinical efficacy is limited by poor tumor selectivity, dose-dependent toxicity, and the development of resistance. Silibinin, a hydrophobic natural compound wit...
Update on the role of mycobiome in Gastrointestinal cancers: mechanisms and therapeutic implications [0.03%]
胃肠癌症中菌丝型真菌组的作用机制及治疗意义的新认识更新报告
Xinyu Zhang,Yulei Li,Demin Cao
Xinyu Zhang
Fungi are a vital component of the gastrointestinal microbiota and are increasingly recognized for their critical roles in the initiation, progression, and therapeutic response of digestive tract cancers. Accumulating evidence indicates tha...
Dian Caturini Sulistyoningrum,Yuni Artha Prabowo Putro,Annisa Fitria Nur Azizah et al.
Dian Caturini Sulistyoningrum et al.
This review provides a summary of recent evidence on vitamin D and osteosarcoma, aiming to elucidate the molecular mechanisms of vitamin D in osteosarcoma and explore its potential role in patient management. Osteosarcoma, a malignant bone ...
Rational design and structural Bioinformatics-Driven discovery of tetrapeptide inhibitors for LIMK-Targeted cancer therapy [0.03%]
基于理性和结构生物信息学的小分子四肽抑制剂设计及发现用于LIM激酶抗癌靶向治疗
Nagarajan Hemavathy,Sampathkumar Ranganathan,Vetrivel Umashankar et al.
Nagarajan Hemavathy et al.
LIM kinases (LIMK1 and LIMK2) serve as critical regulators of microtubule dynamics and mitotic progression, positioning them as promising targets for cancer therapy. However, most existing LIMK inhibitors lack specificity and cause toxic si...
mTORC1 inhibition by metformin synergizes with dendrosomal nano-curcumin to induce apoptosis via modulation of pro- and anti-apoptotic proteins in breast cancer cells [0.03%]
二甲双胍通过抑制mTORC1与纳豆壳CURCUVEM合作调节乳腺癌细胞促凋亡和抗凋亡蛋白诱导凋亡作用的协同研究
Zohreh Jahani,Majid Sadeghizadeh,Jamshid Davoodi
Zohreh Jahani
Breast cancer often carries a poor short-term prognosis because of its strong tendency for early distant metastasis and recurrence. Effective treatment requires strategies that disrupt the anabolic pathways cancer cells use to overcome ther...
Systemic exosome abundance and comprehensive proteome profile of lymphoma-derived exosomes: Insights into host-tumor interactions [0.03%]
系统性外泌体含量与淋巴瘤衍生外泌体的全面蛋白质谱分析：揭示宿主-肿瘤相互作用的见解
Saima Syeda,Kavita Rawat,Sana Khan et al.
Saima Syeda et al.
Exosomes are among the various secreted vesicles which play a pivotal role in tumor growth and progression. In fact, tumor-derived exosomes are considered to be an excellent reservoir of oncogenic factors which govern the metastatic potenti...
Enhanced cytotoxic and antitumour properties of Cleome gynandra on Ehrlich ascites carcinoma in swiss albino mice [0.03%]
罗拉草对小鼠艾氏腹水瘤细胞的增效cytotoxic和抗肿瘤作用
Sivakumar Ramalingam,Gajavarthini Senthilkumar,Renuka Saravanan
Sivakumar Ramalingam
The current investigation evaluated the antitumor efficacy of a standardized hydroalcoholic extract of Cleome gynandra leaves (HAECG) using the Ehrlich ascites carcinoma (EAC) model in Swiss albino mice. Administration of HAECG produced a s...
Microbiota relationship between breast, colorectal, and lung cancer types [0.03%]
乳腺癌、结直肠癌和肺癌之间的微生物关系
Ebru Kanimdan,Caspar Bundgaard-Nielsen,Vildan Betul Yenigun et al.
Ebru Kanimdan et al.
Colorectal cancer (CRC), breast cancer (BC), and lung cancer (LC) are among the most common and deadly malignancies worldwide. In recent years, the role of tumor-associated microbiota in the initiation and progression of cancer has attracte...
Ethical challenges and governance of artificial intelligence in hepatocellular carcinoma management : Wan DL et al. Ethical considerations in AI for hepatocellular carcinoma [0.03%]
人工智能在肝细胞癌管理中的伦理挑战及治理： Wan DL等。论人工智能在肝细胞癌中的伦理考量
Da-Long Wan,Sheng-Zhang Lin
Da-Long Wan
The integration of artificial intelligence (AI) into hepatocellular carcinoma (HCC) management introduces significant ethical challenges, which are shaped by the disease's unique epidemiology and clinical complexity. In this review, we syst...
Ultrasound-Stimulated microbubble cavitation improved tumor perfusion and promoted tumor vascular normalization in a rabbit VX2 tumor model [0.03%]
高强度聚焦超声通过微气泡介导血管内皮生长因子治疗兔VX2肿瘤的实验研究
Tingting Luo,Luhua Bai,Lei Yao et al.
Tingting Luo et al.
Tumor hypoxia poses a major challenge in tumor therapy. Many strategies have been explored to alleviate tumor hypoxic microenvironment to improve the efficacy of tumor therapy. Ultrasound-stimulated microbubbles cavitation (USMC) was proved...