Macrophage migration inhibitory factor (MIF): a Janus-faced cytokine in viral pathogenesis and host defense [0.03%]
巨噬细胞迁移抑制因子(MIF)：在病毒发病机制和宿主防御中的双面作用的细胞因子
Mohamed J Saadh,Faris Anad Muhammad,Abdulkareem Shareef et al.
Mohamed J Saadh et al.
Macrophage migration inhibitory factor (MIF) is one of several pivotal cytokines that contribute to orchestrate immune regulation, inflammation, and cell survival, acting as both a mediator of host defense and a factor that viruses can expl...
Lactylation-related multigene signature in multiple myeloma: integrated prognostic stratification, immune landscape profiling, and therapeutic guidance [0.03%]
多发性骨髓瘤中乳酰化相关多基因标志物：整合预后分层、免疫图谱分析和治疗指导
Wuyang Zhang,Shuai Ming,Peng Cheng et al.
Wuyang Zhang et al.
Multiple myeloma (MM) is an incurable hematologic malignancy with high heterogeneity and poor prognosis. Lactylation, a novel post-translational modification, drives tumor progression and immune dysregulation, yet its prognostic value in MM...
STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease [0.03%]
STAT6抑制稳定诱导产生的调节性T细胞并增强其在炎症性肠病治疗中的潜力
Rubén D Arroyo-Olarte,Flaubert A Pérez-Noriega,María Fernanda Correa-Pérez et al.
Rubén D Arroyo-Olarte et al.
The development and stability of induced regulatory T cells (iTregs) are essential for their immunosuppressive function and therapeutic potential in inflammatory diseases. Although Treg-based immunotherapy offers promise for restoring immun...
History of cold urticaria research: from systematic studies of the 19th century to modern prospective strategies in clinical practice [0.03%]
冷性荨麻疹研究的历史：从19世纪系统研究到现代临床实践中的前瞻性策略
Maria Zofia Lisiecka
Maria Zofia Lisiecka
This study aimed to determine the current prospective strategies for diagnosing and treating cold urticaria based on the history of its research since the 19th century. The study analysed relevant scientific sources, and the main historical...
Dexmedetomidine protects against postoperative neurocognitive disorder by mitigating mitochondrial dysfunction through regulating the IP3R-GRP75-VDAC1 complex-mediated calcium transport [0.03%]
依托咪酯通过调节IP3R-GRP75-VDAC1复合体介导的钙离子转运来缓解线粒体功能障碍从而对抗术后神经认知障碍
Qifan Huo,Yuming Zhang,Jianwei Guo et al.
Qifan Huo et al.
Dexmedetomidine (Dex), an α2 adrenergic receptor agonist, has been shown to exert protective effects against postoperative neurocognitive disorder (PND) following anesthesia and surgery. This study aimed to investigate the underlying mecha...
Characterization of the neuromuscular manifestations in patients with IgG4-related disease: a systematic review [0.03%]
IgG4相关疾病患者的神经肌肉表现特征：一项系统性回顾
Renan Fabri Rosenstein,José Pedro Baima,Henrique Ayres Mayrink Giardini et al.
Renan Fabri Rosenstein et al.
Immunoglobulin G4-related disease (IgG4-RD) neurological involvement typically presents as pachymeningitis. However, there have been reports of neuromuscular manifestations. To review the involvement of the peripheral nerves, neuromuscular ...
Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort [0.03%]
肌炎自身活动和免疫失衡是idiopathic炎症性肌病患者感染的关键驱动因素：来自MYOTReCS队列的结果
Karina Santana-de-Anda,Jiram Torres-Ruiz,Nancy R Mejía-Domínguez et al.
Karina Santana-de-Anda et al.
Patients with idiopathic inflammatory myopathies (IIM) are at increased risk for infections. Identifying clinical and immunological biomarkers predictive of infection is essential. We included 169 patients from the MYOTReCSZ cohort, all wit...
Seasonal pattern, global search trend, and public interest in arthritis from 2004 to 2022: an infodemiology study [0.03%]
2004至2022年全球风湿性疾病季节性模式、搜索趋势及公众兴趣的信息化学研究
Yan-Yu Zhu,Xiao Hu,Xiao-Song Wang et al.
Yan-Yu Zhu et al.
Arthritis is a common condition that causes articular cartilage damage, joint tissue destruction, and ligament involvement, representing one of the leading causes of disability worldwide. This study aimed to analyze long-term trends and cha...
SerpinB9 sustains CIITA to orchestrate MHC-II expression and Th1 differentiation in β-glucan-induced macrophages [0.03%]
SerpinB9通过维持CIITA来调控β-葡聚糖诱导的巨噬细胞中的MHC-II表达和Th1分化
Xin Huang,Jun Ding,Yongzhe Hao et al.
Xin Huang et al.
Whole glucan particles (WGP) enhance macrophage immune function, while serine protease inhibitor B9 (SerpinB9)-a molecule known to promote tumor immune escape-has an unclear role in WGP-induced macrophage function. In this study, we found t...
Performance of QuantiFERON tests for detecting latent tuberculosis infections: A Meta-analysis [0.03%]
检测潜伏性结核感染的QuantiFERON试验性能的 meta 分析
Jelkeba Bali Weyesa,Mengistu Legesse,Balako Gumi et al.
Jelkeba Bali Weyesa et al.
Early detection of latent tuberculosis (TB) is crucial for prevention. However, there is a debate over the effectiveness of QuantiFERON tests versus tuberculin skin tests. This meta-review critically evaluated QuantiFERON (QFT) tests for la...