Overcoming resistance to immune checkpoint inhibitors in cancer: translational mechanisms, dynamic biomarkers, clinically actionable combination strategies, and comparative checkpoint biology [0.03%]
克服癌症免疫检查点抑制剂的抗性：转化机制、动态生物标志物、临床可操作的联合策略和比较检查点生物学
Rumeysa Berra Karataş,Yaren Alras,Sarenur Teki̇ner et al.
Rumeysa Berra Karataş et al.
Immune checkpoint inhibitors (ICIs) have reshaped cancer therapy by restoring antitumor immune activity, yet primary and acquired resistance continue to limit durable clinical benefit. This review integrates the major tumor-intrinsic and tu...
Hidden Burden: Liver and Gastrointestinal Involvement in Chronic Granulomatous Disease [0.03%]
隐匿的重担——慢性肉芽肿病的肝肠道受累
Zehra Genç Ozbay,Saliha Esenboga,Elif Soyak Aytekin et al.
Zehra Genç Ozbay et al.
Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by defective reactive oxygen species production, leading to recurrent infections, chronic inflammation, and immune dysregulation. Hepatic and gastrointestinal (...
Spontaneous lymphoproliferation differentiates two groups of HTLV-1 asymptomatic carriers: with and without high cell proliferation and death [0.03%]
自发性淋巴细胞增殖区分了HTLV-1无症状携带者的两类人群：一类是高细胞增殖和死亡，另一类则没有这些特征
Marta de Souza Porto,Tatiana Mitiko,Victor Folgosi et al.
Marta de Souza Porto et al.
HTLV-1 infection causes chronic immune activation and a prolonged asymptomatic phase, but the functional features that define early disease remain unclear. We evaluated whether spontaneous proliferation (SP) and related functional immune pa...
Clustering of rheumatoid arthritis patients: an unsupervised machine learning approach for characterizing the TNFi response [0.03%]
肿瘤坏死因子抑制剂治疗类风湿关节炎患者的亚型分类：无监督机器学习方法
Pedro Augusto Silva Dos Santos Rodrigues,Katarina Mattos Brandão,Lilian de Sá Garcia Landeiro et al.
Pedro Augusto Silva Dos Santos Rodrigues et al.
This study aimed to identifydistinct profiles of response to Tumor Necrosis Factor inhibitors (TNFi) in rheumatoid arthritis (RA) patients using unsupervised machine learning to integrate clinical, demographic, and genetic data. A cohort of...
Comparative analysis of multiple sclerosis burden in China and India from 1990 to 2021 based on the Global Burden of Disease Study 2021 [0.03%]
基于全球疾病负担研究2021的多发性硬化症在中国和印度1990至2021年的疾病负担比较分析
Zhuo-Lei Cai,Fei Dong,Jinyu Ma et al.
Zhuo-Lei Cai et al.
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system and one of the leading causes of non-traumatic neurological disability among young adults worldwide. In recent years, an increasing number...
Comparative Study
Immunologic research. 2026 Aug 17;74(1):87. DOI:10.1007/s12026-026-09821-y 2026
Immunoglobulin-mediated immune dysregulation in recurrent pregnancy loss: mechanisms, biomarkers, and therapeutic perspectives [0.03%]
免疫球蛋白介导的复发性妊娠丢失免疫失常：机制、生物标志物及治疗前景
Kamala C,Pallavi Shekar,Umme Kulsum et al.
Kamala C et al.
Recurrent pregnancy loss (RPL) is a multifactorial reproductive disease that is typified by repeated pregnancy loss with immune dysregulation emerging as a critical contributing factor. Immunoglobulins are among the immune components that a...
Yang Wu,Li-Na Jiang,Jing-Ru Wu et al.
Yang Wu et al.
This study aims to assess the circulating galectin-3 (Gal-3) levels in patients with systemic lupus erythematosus (SLE) and explore the major related influencing factors. Systematic searches of all relevant English articles were conducted i...
Efficacy and safety of Janus kinase and TYK2 inhibitors in the treatment of generalized pustular psoriasis and palmoplantar pustulosis: a systematic review [0.03%]
Janus激酶和TYK2抑制剂治疗泛发性脓疱病和掌跖脓疱病的疗效与安全性：系统评价
Asma Rasouli,Nazila Heidari,Amirhossein Heidari et al.
Asma Rasouli et al.
Pustular psoriasis (PP), including generalized pustular psoriasis (GPP) and palmoplantar pustulosis (PPP), is a rare and severe inflammatory dermatosis distinct from plaque psoriasis and associated with significant unmet therapeutic needs. ...
Association of isolated anti-Scl-70 positivity with subclinical cardiac involvement in ANA-positive individuals: an electrocardiographic diastolic function analysis (Subclinical Cardiac Involvement in Isolated Anti-Scl-70 Positivity) [0.03%]
抗Scl-70阳性与ANA阳性个体亚临床心脏受累的关系：一项以心电图为基础的舒张功能分析(孤立性抗Scl-70阳性的亚临床心脏受累)
Merve Özderya,Fatih Gülçebi
Merve Özderya
Anti-topoisomerase I (anti-Scl-70) antibodies are strongly associated with systemic sclerosis and fibrotic organ involvement. However, their significance in ANA-positive individuals without established systemic sclerosis remains unclear. We...
Diosmetin alleviates retinal ischemia-reperfusion injury through SIRT1-mediated suppression of oxidative stress, inflammation, and PANoptosis [0.03%]
二氢杨梅素通过SIRT1介导的氧化应激、炎症和PANoptosis抑制缓解视网膜缺血再灌注损伤
Peng Fu,Xiaobo Wan,Chunrong Zheng et al.
Peng Fu et al.
Background: Retinal ischemia-reperfusion (RI/R) injury causes vision loss and lacks effective treatments. The role of diosmetin (DIO) in this condition, particularly through the SIRT1/Nrf2 pathway and its effect on PANopt...