ProBDNF promotes LPS-induced pro-inflammatory polarization of alveolar macrophages via the Notch1 signaling pathway [0.03%]
前脑源性神经营养因子通过诺特定价1信号通路促进脂多糖诱导的肺泡巨噬细胞向促炎性方向极化
Ye Gao,Ni Wang,Zhaoyang Xiao
Ye Gao
Macrophage polarization is involved in the pathogenesis of acute respiratory distress syndrome (ARDS). However, the upstream regulators that shape macrophage inflammatory phenotypes under pathological conditions remain poorly understood. Pr...
EGR1 regulates degranulation and mediator release in C48/80-induced pseudo-allergic reactions [0.03%]
EGR1调节C48/80诱导的伪过敏反应中的脱颗粒和介质释放
YiZhao Sun,Heng Li,Juntao Li et al.
YiZhao Sun et al.
Allergic diseases significantly impair human health and quality of life, and IgE-independent pseudo-allergic reactions represent a common yet incompletely understood subtype with limited diagnostic and therapeutic options. Cationic secretag...
Crosstalk between the monocytes and coagulation factor VⅡa aggravates the inflammation in patients with CAD [0.03%]
单核细胞与凝血因子VIIa的相互作用可加重CAD患者的炎症反应
Baofu Wang,Wenbo Han,Shengyao Xiu et al.
Baofu Wang et al.
The underlying proinflammatory mechanism of coagulation factor VⅡ in coronary artery disease (CAD) remains unclear. According to the inclusion criteria, 24 non-CAD subjects and 24 patients with CAD were enrolled. The expression levels of p...
Anti-neutrophil cytoplasmic antibodies in interstitial lung disease: results from a cross-sectional study and meta-analysis [0.03%]
抗中性粒细胞胞浆抗体在间质性肺疾病中的相关性：横断面研究和荟萃分析的结果
Dongru Du,Faping Wang,Min Zhu et al.
Dongru Du et al.
This study aims to investigate the prevalence, clinical characteristics, and prognostic significance of anti-neutrophil cytoplasmic antibodies (ANCA) across different subtypes of interstitial lung disease (ILD), specifically idiopathic pulm...
Meta-Analysis
Immunologic research. 2026 May 12;74(1):54. DOI:10.1007/s12026-026-09772-4 2026
Fine specificity of antibodies to SARS-CoV-2 nucleoprotein in patients with COVID-19 [0.03%]
COVID-19患者SARS-CoV-2核蛋白抗体的细特异性
Caterina Porciani,Francesco Pisani,Maria Laura Manca et al.
Caterina Porciani et al.
The production of antibodies against viral structural proteins such as the spike (S) and the nucleocapsid (N) is a hallmark of SARS-CoV-2 infection. The N protein contains several immunogenic regions. In this work we analysed epitope specif...
Effectiveness and safety of efgartigimod in myasthenia gravis: A meta-analysis of different antibody subtypes [0.03%]
埃加替吉莫单抗治疗不同类型抗体的重症肌无力有效性和安全性：meta分析研究
Haneen Sabet,Abrar AbuHamdia,Mohamed Ahmed Zanaty et al.
Haneen Sabet et al.
Objective: To assess the effectiveness and safety of intravenous efgartigimod in patients with myasthenia gravis (MG) and to compare treatment responses between anti-acetylcholine receptor antibody (AChR-Ab)-positive and ...
Meta-Analysis
Immunologic research. 2026 May 7;74(1):53. DOI:10.1007/s12026-026-09786-y 2026
An integrated AI-driven vaccine design process: a systematic review of workflows from generative design to translational prediction [0.03%]
一种综合的人工智能驱动的疫苗设计流程：从生成设计到转化预测的工作流系统回顾
Mohammadreza Shafaati,Farnaz Nikzadjamnani,Masoud Ghorbani
Mohammadreza Shafaati
Traditional vaccine development faced significant hurdles, including lengthy timelines and high costs, which hindered rapid responses to pathogens. Although the emergence of AI offered transformative potential, the necessity for a fully int...
Natural history and long-term outcomes of kawasaki disease following spontaneous defervescence: 31 years of experience from North India [0.03%]
印度北方31年川崎病自发热退的自然史及长期预后学研究
Rakesh Kumar Pilania,Prabal Barman,Gayathri Cv et al.
Rakesh Kumar Pilania et al.
Intravenous immunoglobulin (IVIg) is the standard of care for the treatment of Kawasaki disease (KD) and should be administered within 10 days of the onset of fever. Management guidelines for children with KD who defervesce spontaneously ar...
A case of autoimmune hemolytic anemia with acquired functional mutation of the TLR7 [0.03%]
TLR7功能获得性突变导致的自身免疫性溶血性贫血病例报告
Yu Han,Hongbo Chen,Ying Li et al.
Yu Han et al.
This article presents a case of recurrent autoimmune hemolytic anemia in a child with a gain-of-function (GOF) mutation of the TLR7. This patient's condition contrasts with the six previously documented cases of GOF mutations in the TLR7, t...
Immune cell annotation in the single-cell studies: technologies, challenges, and integrative solutions [0.03%]
单细胞研究中的免疫细胞注释：技术、挑战与整合解决方案
Sabrina George,Nor Adzimah Johdi
Sabrina George
Single-cell RNA sequencing has transformed immunological research by enabling high-resolution transcriptional profiling of individual immune cells. Despite its transformative impact, annotating immune cells based solely on transcriptomic da...