Investigating the Efficacy of the CRISPR/Cas9 Gene-Editing System for Targeting the HBB FSC 36-37 (-T) Mutation Locus in Hematopoietic Stem Cells [0.03%]
探究CRISPR/Cas9基因编辑系统在造血干细胞中靶向HBB FSC 36-37 (-T)突变位点的效率
Nasim Mayeli Fereydani,Hamid Galehdari,Elham Hoveizi et al.
Nasim Mayeli Fereydani et al.
The emergence of genome editing using the CRISPR/Cas9 system has opened up new possibilities and significantly improved the potential for long-term gene therapy of beta-thalassemia. In Iran, FSC 36/37 (-T) is one of the most common mutation...
Advances in Tissue Culture-Free Genetic Engineering and Genome Editing of Peanut [0.03%]
无组织培养花生基因工程与基因编辑研究进展
Tariq Alam
Tariq Alam
Plant transformation and genome editing are pivotal in advancing peanut biotechnology, yet traditional tissue culture-dependent methods are hindered by lengthy protocols, genotype dependency, and somaclonal variation. CRISPR/Cas technologie...
The Role of Neutrophil Extracellular Traps (NETs) in the Pathogenesis of Ovarian Cancer: New Insight and Future Perspectives [0.03%]
卵巢癌中中性粒细胞胞外诱捕网(NETs)的作用：新视角和未来展望
Khadijeh Lorestani,Sara Ghorbanzade,Sania Rahimi et al.
Khadijeh Lorestani et al.
Ovarian cancer is a highly heterogeneous malignancy characterized by genetic diversity, clonal evolution, and therapeutic resistance, making it one of the deadliest gynecologic cancers worldwide. Neutrophil extracellular traps (NETs), compo...
Sustainable Production of Biofuels from Lignocellulosic Biomass Using Microbial Applications: Status, Challenges and Prospects [0.03%]
利用微生物技术可持续生产木质纤维素生物燃料：现状、挑战与前景
Ashish Kapoor,Amit Kumar Tiwari,S C Tripathi et al.
Ashish Kapoor et al.
The global pursuit of sustainable and renewable energy sources has intensified interest in biofuel production from lignocellulosic biomass. There are challenges for achieving sustainable biofuel production and utilization of lignocelluloses...
Rationally-Stabilized Inhibited State of IMPDH Proposes a Novel Targeting Approach Involving Its Cross-Domain and Assembly Suppression [0.03%]
理性的稳定抑制状态的IMPDH提出了一个新的靶点方法涉及它的跨域和集合抑制作用
Samira Sattari,Razieh Yazdanparast,Ebrahim Barzegari
Samira Sattari
Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step of GTP biosynthesis. The multilevel regulation of the enzyme complicates its inhibition to treat diseases such as retinitis pigmentosa (RP) where modulation of the...
Priyasha De,Vyasraj G Bhat,Vibha Kamath et al.
Priyasha De et al.
Bacteriophages, viruses that specifically target and lyse bacterial cells, were first discovered over a century ago. At present, as drug-resistant bacterial infections and cancer pose some of the greatest challenges to global health, phage ...
Cost-Effective Production of Biologically Active Leukemia Inhibitory Factor for Mouse Embryonic Stem Cell Culture [0.03%]
一种用于小鼠胚胎干细胞培养的生物活性白血病抑制因子低成本制备方法
Imtiaz Nisar Lone,Esin Ozkuru Sekeroglu,Gkamze Impraimoglou Kafaz et al.
Imtiaz Nisar Lone et al.
Leukemia inhibitory factor (LIF), a glycoprotein in the interleukin-6 family, is essential for maintaining the pluripotency and self-renewal of mouse embryonic stem cells (mESCs) by activating the JAK/STAT pathway and preventing spontaneous...
Computational Design of a Multi Epitope Vaccine Against Staphylococcus warneri for Combatting Recurrent UTIs and Skin Infections [0.03%]
一种针对耐甲氧西林万宁葡萄球菌复发性尿路感染和皮肤感染的多表位疫苗的计算设计方法研究
Muhammad Naveed,Khizra Jabeen,Tariq Aziz et al.
Muhammad Naveed et al.
Staphylococcus warneri is a pathogenic bacterium that causes multiple life-threatening diseases, such as urinary tract and skin infections globally, with approximately one million new cases reported each day. The World Health Organization (...
Designing Novel Aspartic Protease (NAP) Using Ancestral Sequence Reconstruction (ASR) for Cheesemaking [0.03%]
利用祖先序列重建（ASR）设计新型天冬氨酸蛋白酶（NAP）用于奶酪制作
Shilan S Saleem,Oluwasola Michael Akinola,Mohd Basyaruddin Abdul Rahman et al.
Shilan S Saleem et al.
Rhizomucor miehei protease (RMP), a chymosin-like fungal enzyme, is among the most widely used non-animal milk coagulant enzymes (MCEs) in cheese production. However, like other current MCEs, RMP exhibits non-specific proteolytic activity a...
Application Advances of Lentiviral Vectors: From Gene Therapy to Vaccine Development [0.03%]
lentiviral载体的应用进展：从基因治疗到疫苗开发
Enyue Fang,Guodan He,Yutong Chang et al.
Enyue Fang et al.
Since their development in the 1990s, the applications of lentiviral vectors have rapidly extended to the fields of gene and cancer therapy, as well as vaccine development, owing to their unique advantages of efficiently transducing both di...