Rationally-Stabilized Inhibited State of IMPDH Proposes a Novel Targeting Approach Involving Its Cross-Domain and Assembly Suppression
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Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step of GTP biosynthesis. The multilevel regulation of the enzyme complicates its inhibition to treat diseases such as retinitis pigmentosa (RP) where modulation of the isozyme IMPDH1 is d... ...
