Immunotherapy targeting drug-tolerant Mycobacterium tuberculosis persisters accelerates tuberculosis cure in preclinical models [0.03%]
针对药物耐受型结核分枝杆菌休眠菌的免疫治疗可加速结核病治愈（基于临床前模型）
Styliani Karanika,Tianyin Wang,Addis Yilma et al.
Styliani Karanika et al.
Mycobacterium tuberculosis (Mtb) remains a global health crisis, ranking among the deadliest infectious diseases worldwide. In response to the World Health Organization's call for therapeutic vaccines to complement antibiotic regimens and r...
Plasma chondroitin sulfate predicts the effectiveness of fluid resuscitation strategies in patients with sepsis [0.03%]
血浆硫酸软骨素可预测脓毒症患者液体复苏方案的有效性
Kaori Oshima,Bailu Yan,Ran Tao et al.
Kaori Oshima et al.
Background: Plasma heparan sulfate, a glycosaminoglycan released during endothelial glycocalyx degradation, predicts sepsis mortality. Chondroitin sulfate is a circulating glycosaminoglycan not specific to glycocalyx degr...
Notch1 O-GlcNAcylation drives tumor stemness and mechanoadaptation to a stiff microenvironment and promotes chordoma recurrence [0.03%]
NOTCH1 O-GlcNAcylation促进肿瘤干细胞向刚性微环境适应的机械调节并促进软骨肉瘤复发
Chengjie Lian,Weiyan Peng,Peiqiang Su et al.
Chengjie Lian et al.
Chordoma are rare malignant osseous neoplasms with a striking rate of recurrence. Primary chordomas typically originate from embryonic notochord remnants, whereas recurrent chordomas usually stem from tumor cells infiltrating bone or cartil...
Reduced glycoprotein hormone β-5 links male aging and testosterone decline to increased adiposity [0.03%]
甘蛋白激素β-5降低与男性衰老、睾丸素下降和脂肪增加有关
Gengmiao Xiao,Aijun Qian,Zhuo Gao et al.
Gengmiao Xiao et al.
Aging commonly causes decline of testosterone or estrogen, leading to overaccumulation of fatness in males or females, respectively. Although such phenomenon can be readily explained by estrogen's direct action on adipocytes in females, acc...
Posttranscriptional regulation of PD-1 by PRMT5/WDR77 complex shapes T cell effector function and antitumor immunity [0.03%]
PRMT5/WDR77复合体对PD-1的转录后调控塑造T细胞效应功能和抗肿瘤免疫反应
Yinmin Gu,Yongbo Pan,Chang Pan et al.
Yinmin Gu et al.
The regulation of the programmed cell death protein 1 (PD-1) gene, PDCD1, has been widely explored at transcription and posttranslational levels in T cell function and tumor immune evasion. However, the mechanism for PDCD1 dysregulation at ...
Cell-free DNA epigenomic profiling enables noninvasive detection and monitoring of translocation renal cell carcinoma [0.03%]
无细胞DNA表观基因组谱分析可实现转位性肾细胞癌的非侵入式检测和监测
Simon Garinet,Karl Semaan,Jiao Li et al.
Simon Garinet et al.
TFE3 translocation renal cell carcinoma (tRCC), an aggressive kidney cancer driven by TFE3 gene fusions, is frequently misdiagnosed owing to morphologic overlap with other kidney cancer subtypes. Conventional liquid biopsy assays that detec...
Base editing rescues seizures and sudden death in a SCN8A mutation-associated developmental epileptic encephalopathy model [0.03%]
基于编辑修复SCN8A突变相关发育性癫痫性脑病模型中的癫痫发作及突发死亡现象
Caeley M Reever,Alexis R Boscia,Tyler Cj Deutsch et al.
Caeley M Reever et al.
SCN8A encodes the voltage-gated sodium channel Nav1.6, which plays a key role in facilitating neuronal excitability. Mutations in SCN8A, particularly gain-of-function variants, cause SCN8A developmental and epileptic encephalopathy (DEE), a...
Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease [0.03%]
Luspatercept改善了镰状细胞病Townes小鼠模型的疾病表型和并发症
Maiko Sezaki,Tian Li,Mingzhe Pan et al.
Maiko Sezaki et al.
Preclinical data demonstrating that luspatercept mitigates vaso-occlusive and anemia-related complications in the Townes sickle cell model provide a strong rationale for its evaluation in SCD patients. ...
SH3BP5L triggers the RAB11A-regulated integrin recycling network implicated in breast cancer metastasis [0.03%]
SH3BP5L触发的RAB11A调控的整合素回收入胞网络参与乳腺癌转移
Huayi Li,Maria Chiara De Santis,Francesco A Tucci et al.
Huayi Li et al.
Metastatic progression in aggressive breast cancer (BC) depends on a tightly controlled vesicular recycling network regulated by RAB11, a small guanosine triphosphate enzyme (GTPase). In a cohort of more than 1,000 patients with BC, we iden...
A hit for base editing: treatment of developmental epilepsy in a mouse model [0.03%]
基于编辑治疗发育性癫痫的小鼠模型研究取得突破性进展
Sophie F Hill,Ethan M Goldberg
Sophie F Hill
CRISPR/Cas9 base editing holds the potential to treat disease caused by single-nucleotide variants. In contrast with conventional CRISPR/Cas9 approaches, base editing enzymatically induces precise DNA alterations and can directly correct di...