TGFb signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration [0.03%]
转化生长因子β信号促进胶质细胞活化和TDP-43蛋白病在额颞叶变性器官样模型中的作用
Arren C Ramsey,Xiao-Yan Tang,Magdalena J Macias et al.
Arren C Ramsey et al.
Dominant mutations in Progranulin (GRN) gene cause frontotemporal lobar degeneration (FTLD-GRN), whereas homozygous GRN mutations lead to neuronal ceroid lipofuscinosis, a childhood neurodegenerative disorder. While recent transcriptomic st...
Targeting CIC::DUX4 sarcoma with Minnelide in a dual recombinase-initiated genetically engineered mouse model [0.03%]
利用Minnelide靶向CIC::DUX4肉瘤的双重组酶启动的基因工程小鼠模型中的致癌融合基因
MaKenna R Browne,Axel V Silver,Risha Banerjee et al.
MaKenna R Browne et al.
CIC::DUX4 sarcoma (CDS) is a lethal cancer driven by a fusion between tumor suppressor Capicua (CIC) and pioneer transcription factor double homeobox 4 (DUX4). We previously generated three genetically engineered mouse models (GEMMs) of CDS...
Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1 [0.03%]
急性髓系白血病中线粒体蛋白输入增强增加对线粒体蛋白酶LONP1的依赖性
Matthew Tcheng,Veronique Voisin,Geethu Emily Thomas et al.
Matthew Tcheng et al.
Most mitochondrial proteins are nuclear encoded, translated in the cytosol, and imported into the mitochondria. Through gene expression analysis and functional assays, we demonstrated that mitochondrial protein import is increased in acute ...
GLUT9b- and ABCG2-mediated collecting duct urate transport uncover a vasopressin-independent mechanism of renal water reabsorption [0.03%]
GLUT9B和ABCG2介导的集合管尿酸转运揭示了肾水分重吸收的血管加压素非依赖性机制
Mohamad Hadla,Jean Marc Mardirossian,Daniel G Bichet et al.
Mohamad Hadla et al.
Renal water reabsorption is classically regulated by vasopressin V2 receptor (V2R) signaling through cyclic AMP and protein kinase A, driving apical accumulation of aquaporin-2 (AQP2). However, collecting duct water handling is also modulat...
Erratum to Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy [0.03%]
IgA肾病中GalNAc-T14丧失导致的O-糖基化缺陷与B细胞归巢改变的关系的订正公告
Sindhuri Prakash,Nicholas J Steers,Yifu Li et al.
Sindhuri Prakash et al.
Published Erratum
The Journal of clinical investigation. 2026 Jun 15;136(12):e208844. DOI:10.1172/JCI208844 2026
Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling [0.03%]
非活性β1整合素作为血管生成素/TIE2/FOXO1信号的连接支架
Tuomas Sipilä,Srinivas Kumar Ponna,Abhinandan Venkatesha Murthy et al.
Tuomas Sipilä et al.
The blood and lymphatic vascular systems are regulated by angiopoietin (ANGPT) growth factors, which signal via endothelial TIE receptor tyrosine kinases and integrins. However, mechanistic understanding of how these receptors crosstalk is ...
Aging reprograms microglia toward an inflammasome-linked response to traumatic brain injury [0.03%]
衰老通过重新编程小胶质细胞向创伤性脑损伤的炎性体连锁反应发展
Josh M Morganti,Adam D Bachstetter
Josh M Morganti
Traumatic brain injury (TBI) disproportionately kills and disables older adults, yet the biology driving this vulnerability remains unresolved. In this issue of the JCI, Lu et al. combined single-cell transcriptomics, metabolomics, and chro...
Polyendocrine metabolic ovarian syndrome (PMOS)/polycystic ovary syndrome (PCOS): current and future trends [0.03%]
多激素代谢性卵巢综合征(PMOS)和多囊卵巢综合征(PCOS)：现状与未来趋势
Jessica L Chan,Irene Masini,Margareta D Pisarska
Jessica L Chan
Polycystic ovary syndrome (PCOS), also known as polyendocrine metabolic ovarian syndrome (PMOS), is the most common endocrinologic disorder to affect women. Despite this, the pathophysiology of the disease is not entirely known. This has hi...
Host-directed immune therapies: a second front in the battle against sepsis [0.03%]
针对宿主的免疫治疗：脓毒症防治的第二个突破口
Richard S Hotchkiss,Guillaume Monneret
Richard S Hotchkiss
Each year, sepsis claims more lives in the United States than many major cancers and HIV/AIDS combined, yet therapeutic progress has been modest. Adding to this crisis is the alarming rise of multidrug-resistant "superbugs," which increasin...
Bittersweet: how hyperglycemia exacerbates vitiligo progression through the succinate/SUCNR1 axis [0.03%]
苦乐参半：高血糖通过琥珀酸/SUCNR1轴加重白癜风进展
Kaitlyn G O&#x;Donnell,I Caroline Le Poole
Kaitlyn G O&#x;Donnell
Vitiligo is a depigmenting disease marked by progressive T cell-driven destruction of melanocytes in the skin, hair, and mucosa. While vitiligo is known to be a T cell-mediated autoimmune disease, its triggers have remained poorly understoo...