SHMT2 deficiency disrupts transcriptional regulation through homocysteine-mediated suppression of histone lactylation in Huntington's disease models [0.03%]
蛋氨酸腺苷转移酶亚型2缺乏通过同型半胱氨酸介导的组蛋白乳酰化抑制扰乱亨廷顿舞蹈病模型中的转录调控缺陷
Mingqin Lu,Kexin Li,Shanshan Wu et al.
Mingqin Lu et al.
Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and striatal neuron degeneration, primarily affecting medium spiny neurons (MSNs). Despite extensive research...
Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC [0.03%]
空间单细胞蛋白组学揭示了难治性免疫疗法在转移性非小细胞肺癌复杂肿瘤微环境中的特征
Kohsuke Isomoto,Koji Haratani,Takahiro Tsujikawa et al.
Kohsuke Isomoto et al.
Background: Immune checkpoint inhibitors (ICIs) targeting the programmed cell death-1 axis have revolutionized metastatic non-small cell lung cancer (mNSCLC) treatment. However, disease progression remains a concern, and ...
Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients [0.03%]
肝移植到脑死亡的人类受者体内的猪血管性假血友病因子诱发血小板活化和血小板减少症
Liang Zhao,Sokratis A Apostolidis,Aae Suzuki et al.
Liang Zhao et al.
Background: Genetically engineered porcine livers are being developed as a bridge therapy for acute liver failure, providing detoxification and restoration of hepatic protein synthesis. Severe xenograft-associated severe ...
The liver regulates ectopic calcification in Abcc6-deficient models of Pseudoxanthoma Elasticum [0.03%]
ABCC6缺陷假黄瘤病小鼠模型中肝调节异位钙化的作用
Yijie Wang,Baiming Sun,Feiyang Ma et al.
Yijie Wang et al.
Pseudoxanthoma Elasticum (PXE) is a rare disease caused by loss of function of the gene Abcc6 and characterized by ectopic calcification of multiple tissues, but the physiological reasons underlying ectopic calcification in PXE remain uncle...
Impaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease [0.03%]
糖基化受损促进饮食诱导的肝脂肪变性病模型中肝细胞癌的快速转化
Abhishek K Singh,Balkrishna Chaube,Kathryn M Citrin et al.
Abhishek K Singh et al.
Obesity-linked steatosis is a significant risk factor for hepatocellular carcinoma (HCC); however, the molecular mechanisms underlying the transition from Metabolic dysfunction-associated steatotic liver disease (MASLD) to HCC remains uncle...
Methyltransferase complex subunit METTL3 maintains genome stability of erythroid cells via MTHFD1-mediated nucleotide biosynthesis [0.03%]
甲基转移酶复合物组分METTL3通过MTHFD1介导的核苷酸生物合成维持红细胞系的基因组稳定性
Linlin Zhang,Huizhi Zhao,Shihui Wang et al.
Linlin Zhang et al.
N6-methyladenosine (m6A) is a prevalent modification of mammalian mRNA. Increasing evidence has documented diverse roles of m6A in normal cell physiology and diseases. However, its functional role in erythropoiesis remains poorly understood...
Type 2 deiodinase-dependent surge in thyroid hormone controls muscle stem cell quiescence and self-renewal [0.03%]
Ⅱ型脱碘酶依赖性的甲状腺激素脉冲控制肌肉干细胞的静息和自我更新
Maria Angela De Stefano,Raffaele Ambrosio,Cristina Luongo et al.
Maria Angela De Stefano et al.
Stem cells are critical for the homeostasis of adult tissues. Thyroid hormone (TH), whose intracellular concentration is increased by type 2 deiodinase (D2), is involved in many functions, but its role in quiescence is unknown. Here we show...
A therapeutic role for a regulatory glucose transporter1 (GLUT1)-associated lncRNA in GLUT1-deficient mice [0.03%]
调控型葡萄糖转运蛋白1(GLUT1)相关长链非编码RNA在GLUT1缺陷小鼠中的治疗作用
Maoxue Tang,Sasa Teng,Yueqing Peng et al.
Maoxue Tang et al.
The mammalian brain relies primarily on glucose for its energy needs. Delivery of this nutrient to the brain is mediated by the glucose transporter-1 (GLUT1) protein. Low GLUT1 thwarts glucose entry into the brain, causing an energy crisis ...
Estrogen deficiency and risk of hearing loss in pediatric Turner syndrome [0.03%]
雌激素缺乏与儿童特纳综合征听力损失的风险关系
Yan Huang,Liyang Liang,Yanfang Ye et al.
Yan Huang et al.
Background: Estrogen deficiency and progressive hearing loss (HL) are significant concerns in individuals with Turner syndrome (TS). However, whether childhood estrogen deficiency increases HL risk and whether estrogen re...
Colonic Engyodontium fungus triggers neutrophil antimicrobial activity to suppress Lactobacillus johnsonii-derived glutamic acid-maintained Tregs [0.03%]
结肠Engyodontium真菌触发中性粒细胞的抗菌活性以抑制Lactobacillus johnsonii来源的谷氨酸维持的调节性T细胞
Xinying Wang,Haiyang Sun,Ying Tan et al.
Xinying Wang et al.
Isolating commensal fungi from mouse intestines has been challenging, limiting our understanding of their role in intestinal immune homeostasis and diseases. Using an Fc fusion protein of the C-type lectin Dectin-2, we successfully purified...