Inhibiting menin attenuates high-fat diet-induced weight gain by limiting intestinal lipid absorption in mice [0.03%]
抑制menin通过限制小鼠肠道脂质吸收而减缓高脂肪饮食引起的体重增加
Xiaoru Cao,Pingping Zhou,Haiyue Meng et al.
Xiaoru Cao et al.
Intestinal lipid metabolism is essential for systemic energy homeostasis, and its modulation is emerging as a therapeutic strategy for obesity. Menin, a scaffold protein that regulates chromatin remodeling and gene expression, is abundantly...
Endocardial transcription factor HAND2 orchestrates hypoxic and TGF-β signaling to modulate coronary artery formation [0.03%]
心内层转录因子HAND2通过调控缺氧和TGF-β信号通路来调节冠状动脉的形成
Huijuan Wang,Haosheng Zhang,Leiyin Zheng et al.
Huijuan Wang et al.
The endocardium is a major source of coronary angiogenesis and arterialization, through coordinated cell fate transition and migration. However, the transcriptional regulatory network synchronizing cell fate determination and movement remai...
Non-canonical mTORC1-TFEB activation promotes hepatocyte plasticity and high-grade malignancy in hepatocellular carcinoma [0.03%]
非经典的mTORC1-TFEB激活促进肝细胞癌中肝细胞的转分化和高侵袭性恶性行为
Chen Zhang,Xiaojuan Chao,Sha Neisha Williams et al.
Chen Zhang et al.
Hepatocellular carcinoma (HCC) is heterogeneous, and hepatocyte plasticity is linked to poorer patient outcomes. A subset of human HCC harboring Tuberous Sclerosis Complex 1 (TSC1) mutations exhibits more aggressive behavior. TFEB is a mast...
Systems genetics approaches model the heritable architecture of polyendocrine metabolic ovarian syndrome [0.03%]
系统遗传学方法构建多内分泌代谢性卵巢综合征的遗传结构模型
Christy M Nguyen,Leandro M Velez,Youngseo Cheon et al.
Christy M Nguyen et al.
Polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome (PCOS), is the most common endocrine disorder in women and is closely associated with complex diseases such as cardiovascular disease and type 2 di...
Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients [0.03%]
Pegtarazimod限制小鼠急性移植物抗宿主病的死亡率和严重程度并在患者中耐受良好
Verena Holzmüller,Jana Gawron,Ann-Cathrin Burk et al.
Verena Holzmüller et al.
The success of allogeneic hematopoietic cell transplantation (allo-HCT) is limited by acute graft-versus-host disease (aGVHD). We have previously reported that neutrophils can exacerbate tissue damage caused by conditioning regimens. Pegtar...
S100A11 regulates hepatic cholesterol metabolism and promotes steatohepatitis via non-canonical SREBP2 signaling [0.03%]
S100A11通过非经典的SREBP2信号调节胆固醇代谢并促进steatohepatitis
Mingfeng Zhan,Xiumei Xu,Huiyin Wu et al.
Mingfeng Zhan et al.
Dietary cholesterol and de novo cholesterol synthesis in the liver use reciprocal coordination to maintain cholesterol homeostasis. However, high level of dietary cholesterol still promotes excessive cholesterol accumulation in the liver, l...
Molecular evaluation of residual disease following neoadjuvant chemotherapy in triple negative breast cancer CALGB40603 (Alliance) [0.03%]
新辅助化疗后三阴性乳腺癌残留病灶的分子评估CALGB40603（联盟）
Patrick D Rädler,Brooke M Felsheim,Aranzazu Fernandez-Martinez et al.
Patrick D Rädler et al.
Background: Despite therapeutic advances in the early-stage triple negative breast cancer (TNBC) setting, residual disease (RD) following neoadjuvant therapy remains a key predictor of a worse prognosis and is a major obs...
Genomic characterization of therapy-associated polyposis reveals an alkylating mutational signature from prior treatment [0.03%]
基因组特征分析发现治疗关联性多发性息肉病与先前接受的烷化剂治疗相关的突变特征有关
Yashika Parashar,Zsofia Sztupinszki,Aurel György Prósz et al.
Yashika Parashar et al.
Extinction-recruited prefrontal-hypothalamic pathway encodes positive affect to sustain fear extinction in post-traumatic stress mouse model [0.03%]
应激后创伤小鼠模型中招募至前额叶-下丘脑通路的积极情绪编码用于维持恐惧消退
Ze-Jie Lin,Xin-Rong Wu,Ming-Yang Wei et al.
Ze-Jie Lin et al.
Effective psychotherapeutic interventions for post-traumatic stress disorder (PTSD) rely on fear extinction to suppress maladaptive fear responses, yet their long-term efficacy is limited by high relapse rates. Notably, extinction involves ...
Proteasome mutations associated with CANDLE syndrome cause altered neuronal development by dysregulating polyamine synthesis [0.03%]
泛素蛋白酶体突变通过调控多胺合成影响CANDLE综合征患者的神经发育
Clayton W Winkler,Benjamin Schwarz,Katie Williams et al.
Clayton W Winkler et al.
Loss-of-function mutations in PSMB8/beta5i and other components of the 20S proteasome result in multi-organ diseases, such as Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome. Neurocogni...