Base editing rescues seizures and sudden death in a SCN8A mutation-associated developmental epileptic encephalopathy model
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SCN8A encodes the voltage-gated sodium channel Nav1.6, which plays a key role in facilitating neuronal excitability. Mutations in SCN8A, particularly gain-of-function variants, cause SCN8A developmental and epileptic encephalopathy (DEE), a severe epilepsy syn... ...
