Aminopeptidase N: the glucocorticoid gateway linking chronic stress to ferroptosis resistance in liver cancer [0.03%]
氨肽酶N：连接慢性压力和肝癌铁死亡抵抗的糖皮质激素通道
Maowu Luo,Weibo Luo
Maowu Luo
Chronic stress triggers a range of physiological responses that could dysregulate the immune system and metabolic processes, thereby increasing susceptibility to various diseases. In this issue of the JCI, Wu et al. identified a metabolic b...
The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications [0.03%]
GLP-1受体激动剂的不良反应及其降糖和减重作用的研究进展
Ryan J Jalleh,Nicholas J Talley,Michael Horowitz et al.
Ryan J Jalleh et al.
GLP-1 receptor agonist (GLP-1RA) medications have transformed the treatment of type 2 diabetes (T2D) and obesity, with robust evidence for cardiovascular and renal benefits. Nevertheless, GLP-1RA therapy is associated with a pattern of adve...
STING-induced blood-brain barrier opening combined with radiotherapy potentiates antitumor response in a high-grade glioma model [0.03%]
STING诱导的血脑屏障结合放疗增强高级别胶质瘤模型中的抗肿瘤反应
Shashwat Tripathi,Hinda Najem,Lisa Hurley et al.
Shashwat Tripathi et al.
Radiation therapy (RT) is the standard of care for glioblastoma but is not curative. Triggering the cGAS/stimulator of interferon genes (STING) pathway with potent agonists, such as 8803, exerts activity across high-grade glioma preclinical...
Hyperactivation of mTORC1 signaling mediates folliculin deficiency-induced pulmonary cyst formation in Birt-Hogg-Dubé syndrome [0.03%]
mTORC1信号通路的过度活化介导了Birt-Hogg-Dubé综合征肺囊肿的发生发展
Ke Cao,Hui Chen,Ling Chu et al.
Ke Cao et al.
Germline loss-of-function folliculin (FLCN) gene mutations cause Birt-Hogg-Dubé (BHD) syndrome, in which pulmonary cysts are present in up to 90% of the patients. The pathogenic mechanisms underlying lung cyst development in BHD are almost...
Alternative splicing-triggered mRNA decay informs splice-switching targets for neurodevelopmental disorders [0.03%]
可替代剪接触发的mRNA衰变告知神经发育障碍的拼接切换目标
Kaining Hu,Runwei Yang,Jiaming Qiu et al.
Kaining Hu et al.
Alternative splicing-triggered nonsense-mediated mRNA decay (AS-NMD) critically regulates gene expression, but the extent to which neuronal genes are regulated by AS-NMD remains understudied. Here, we identified more than 3,000 developmenta...
PPARα-NFκB heterodimer mediates obesity-induced diastolic dysfunction through autocrine production of IL-6 [0.03%]
肥胖通过自分泌产生IL-6介导PPARα-NFκB异二聚体诱导舒张功能障碍
Shin-Ichi Oka,Eun-Ah Sung,Peiyong Zhai et al.
Shin-Ichi Oka et al.
Obesity is accompanied by increases in free fatty acids (FFAs) in the systemic circulation, and obese patients often develop cardiac hypertrophy and diastolic dysfunction, termed obesity cardiomyopathy. Proinflammatory cytokines, including ...
Variation in antiviral immunity and inflammation pathways precedes HIV-1 infection in a high-risk African cohort [0.03%]
在非洲高危人群中抗病毒免疫和炎症通路的变异发生在HIV-1感染之前
Mwikali Kioko,Shaban Mwangi,Lynn Fwambah et al.
Mwikali Kioko et al.
Background: Susceptibility to human immunodeficiency virus type 1 (HIV-1) infection varies between individuals, but the biological determinants of acquisition risk remain poorly defined. ...
Distinct neuronal alterations distinguish two subtypes of sporadic Creutzfeldt-Jakob disease with shared dysfunctional pathways [0.03%]
不同神经元改变区分出两种散发性克雅病亚型及其共通的受损途径
Katie Williams,Bradley R Groveman,Simote T Foliaki et al.
Katie Williams et al.
Prion diseases are a family of transmissible, neurodegenerative conditions caused by mis-folded proteins called prions. Human cerebral organoids can be infected with prions from sporadic Creutzfeldt-Jakob Disease (sCJD) brain tissue. Initia...
Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma [0.03%]
FGFR1突变通过促进高危型神经母细胞瘤增殖而发挥致癌驱动作用并可作为治疗靶点
Lisa Werr,Jana Boland,Josephine Petersen et al.
Lisa Werr et al.
Fibroblast growth factor receptor 1 (FGFR1) is recurrently mutated at p.N546 in neuroblastoma. We here sought to examine whether mutant FGFR1 is an oncogenic driver, a predictive biomarker, and an actionable vulnerability in this malignancy...
Metabolic surgery mitigates early kidney injury in obese youth with diabetes by suppressing mTORC1/JAK-STAT signaling [0.03%]
代谢手术通过抑制mTORC1/JAK-STAT信号通路减轻肥胖青少年糖尿病早期肾脏损伤
Abhijit S Naik,Fadhl M Alakwaa,Viji Nair et al.
Abhijit S Naik et al.
Background Youth with type 2 diabetes (T2D) and severe obesity face high risk of diabetic kidney disease, which metabolic bariatric surgery (MBS) can mitigate. This study explores structural and molecular changes in kidneys after vertical s...