One Health horsepower in hemostasis: SEL1Lecting stable platelet adhesion [0.03%]
血栓止血中的“One Health”力量：选择稳定的血小板黏附
Caitlin D Schneider,James P Luyendyk
Caitlin D Schneider
Comparative biology approaches have produced foundational discoveries in the mechanisms underlying thrombosis and hemostasis. In this issue of the JCI, work by Dahlgren and colleagues continues in this tradition using an approach that integ...
Type I IFN-dependent FcγRIV signaling in murine monocytes promotes lethal anaphylaxis during viral infections [0.03%]
I型干扰素依赖的FcγRIV信号通路促进小鼠单核细胞在病毒感染过程中的致死性过敏反应
Abdelrahman Elwy,Hossam Abdelrahman,Julia Specht et al.
Abdelrahman Elwy et al.
Anaphylaxis is a life-threatening hypersensitivity reaction. Clinical observations suggest heightened susceptibility during viral infections, yet the mechanisms remain poorly defined. Here, we show that both active and passive IgG-mediated ...
Primed to overreact: virus-induced IFN contributes to antibody-mediated anaphylaxis [0.03%]
过度反应的风险：病毒感染诱导的I型干扰素介导抗原免疫后的过敏反应
Pablo Penaloza-MacMaster
Pablo Penaloza-MacMaster
Florian Kahles,Andreas L Birkenfeld,Nikolaus Marx
Florian Kahles
The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway. Inhibitors of dipeptidyl pep...
Concerns regarding the safety and efficacy of ES-Cu-Captisol for Menkes disease. Reply [0.03%]
关于ES-Cu-Captisol治疗Menkes病的安全性和有效性的担忧。回复
Vishal M Gohil,Michael J Petris,Francesc Palau
Vishal M Gohil
PDGFRβ signaling restrains myocyte function to limit the regenerative capacity of skeletal muscle [0.03%]
PDGFRβ信号传导通过限制骨骼肌再生能力来抑制肌细胞功能
Siwen Xue,Abigail M Benvie,Jamie E Blum et al.
Siwen Xue et al.
Muscle cell fusion is critical for the formation and maintenance of multinucleated myotubes during skeletal muscle development and regeneration. However, the molecular mechanisms directing cell-cell fusion are not fully understood. Here, we...
The hidden world of nanoplastics colliding with neurodegenerative diseases [0.03%]
纳米塑料与神经退行性疾病相互作用的隐秘世界
Andrew B West,Matthew J Campen,Mark Wiesner et al.
Andrew B West et al.
ER-associated degradation pathway protein SEL1L plays an evolutionarily conserved role in platelet adhesion [0.03%]
泛素连接酶SEL1L在血小板粘附中的保守作用及其机制研究
Anna R Dahlgren,Francesca Careddu,Jeffrey W Norris et al.
Anna R Dahlgren et al.
SEL1L is a well-known protein in the ER-associated degradation (ERAD) pathway. While it is known to be expressed in platelets, SEL1L has never been shown to play an active role. Here, we present evidence that SEL1L regulates platelet functi...
Functional characterization of SDHB variants: Advancing succinate dehydrogenase biology and variant curation in hereditary paraganglioma [0.03%]
SDHB变异体的功能表征：增进遗传性副神经节瘤中琥珀酸脱氢酶生物学及变异体筛选的工作进展
Roderick Clifton-Bligh
Roderick Clifton-Bligh
Germline variants in the gene encoding succinate dehydrogenase subunit B (SDHB) occur in around 10% of all patients with pheochromocytomas and paragangliomas (PPGLs). Diagnosis of these variants has profound implications not only for the pa...