Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide bond catalytic activity [0.03%]
硫族酶催化活性赋予黄素单加氧酶2缺血模型中的心肌保护作用
Qingnian Liu,Jiniu Huang,Hao Ding et al.
Qingnian Liu et al.
Myocardial infarction (MI) is characterized by massive cardiomyocyte (CM) death and cardiac dysfunction, and effective therapies to achieve cardioprotection are greatly needed. Here, we report that flavin-containing monooxygenase 2 (FMO2) l...
TMED4 facilitates regulatory T cell suppressive function via ROS homeostasis in tumor and autoimmune mouse models [0.03%]
TMED4通过ROS稳态促进调节性T细胞在肿瘤和自身免疫小鼠模型中的抑制功能
Zhenyan Jiang,Huizi Wang,Xiaoxia Wang et al.
Zhenyan Jiang et al.
Endoplasmic reticulum stress (ERS) plays crucial roles in maintaining Treg stability and function, yet the underlying mechanism remains largely unexplored. Here, we demonstrate that (Tmed4ΔTreg) mice with Treg-specific KO of ERS-related pr...
Leptin signaling maintains autonomic stability during severe influenza infection in mice [0.03%]
瘦素信号在小鼠严重流感感染期间维持自主稳定性
Andrés R Muñoz-Rojas,Adam C Wang,Lisa E Pomeranz et al.
Andrés R Muñoz-Rojas et al.
Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels [0.03%]
乳腺癌通过CX43相关的肿瘤-基质隧道播散至骨髓并获得侵袭性表型
Saptarshi Sinha,Brennan W Callow,Alex P Farfel et al.
Saptarshi Sinha et al.
Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We modeled these interactions with tumor-MSC co-cultures and used an int...
Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer [0.03%]
长期存活的卵巢癌患者的肿瘤微环境的免疫学和分子特征分析
Brad H Nelson,Phineas Hamilton,Minh Tung Phung et al.
Brad H Nelson et al.
BACKGROUNDDespite an overall poor prognosis, about 15% of patients with advanced-stage tubo-ovarian high-grade serous carcinoma (HGSC) survive 10 or more years after standard treatment.METHODSWe evaluated the tumor microenvironment of this ...
Multicenter Study
The Journal of clinical investigation. 2024 Oct 29;134(24):e179501. DOI:10.1172/JCI179501 2024
Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma [0.03%]
Ku70的非经典作用通过FOXP3依赖性机制促进肺腺癌微环境中Tregs的抑制功能
Qianru Huang,Na Tian,Jianfeng Zhang et al.
Qianru Huang et al.
Ku70, a DNA repair protein, binds to the damaged DNA ends and orchestrates the recruitment of other proteins to facilitate repair of DNA double-strand breaks. Besides its essential role in DNA repair, several studies have highlighted noncla...
PCDH15 dual-AAV gene therapy for deafness and blindness in Usher syndrome type 1F models [0.03%]
USH1F耳聋和失明模型中PCDH15的双AAV基因治疗
Maryna V Ivanchenko,Daniel M Hathaway,Eric M Mulhall et al.
Maryna V Ivanchenko et al.
Usher syndrome type 1F (USH1F), resulting from mutations in the protocadherin-15 (PCDH15) gene, is characterized by congenital lack of hearing and balance, and progressive blindness in the form of retinitis pigmentosa. In this study, we exp...
Frameshift mutation spectra overlap between constitutional mismatch repair deficiency tumors and Lynch syndrome tumors [0.03%]
错配修复缺陷综合症肿瘤与林奇综合征肿瘤的框移突变谱的重叠
Yurong Song,Ryan N Baugher,Todd B Young et al.
Yurong Song et al.
MOGAT3-mediated DAG accumulation drives acquired resistance to anti-BRAF/anti-EGFR therapy in BRAFV600E-mutant metastatic colorectal cancer [0.03%]
由MOGAT3介导的DAG累积驱动了BRAF V600E突变型转移性结直肠癌获得性抗BRAF/抗EGFR治疗耐药性
Jiawei Wang,Huogang Wang,Wei Zhou et al.
Jiawei Wang et al.
BRAFV600E-mutant metastatic colorectal cancer (mCRC) is associated with poor prognosis. The combination of anti-BRAF/anti-EGFR (encorafenib/cetuximab) treatment for patients with BRAFV600E-mutant mCRC improves clinical benefits; unfortunate...
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models [0.03%]
组合作为HDAC8和检查点激酶抑制剂在小鼠模型中诱导肿瘤特异性合成致死效应
Ting-Yu Chang,Yan Yan,Zih-Yao Yu et al.
Ting-Yu Chang et al.
The elevated level of replication stress is an intrinsic characteristic of cancer cells. Targeting the mechanisms that maintain genome stability to further increase replication stress and thus induce severe genome instability has become a p...