CSF α-synuclein aggregation is associated with APOE ε4 and progressive cognitive decline in Alzheimer's disease [0.03%]
脑脊液α-突触核蛋白聚集与阿尔茨海默病中APOE ε4和进行性认知下降有关
Qiang Qiang,Loren Skudder-Hill,Tomoko Toyota et al.
Qiang Qiang et al.
At autopsy, around half of the Alzheimer's disease (AD) brains exhibit Lewy body pathology, and the main component of Lewy body pathology is α-synuclein aggregates. This study investigated the prevalence of cerebrospinal fluid (CSF) α-syn...
Age-related differences in long-term memory performance and astrocyte morphology in rat hippocampus [0.03%]
大鼠海马体中与年龄相关的长期记忆表现和星形胶质细胞形态的差异
Yandara A Martins,Camila A E F Cardinali,Andréa S Torrão
Yandara A Martins
Astrocytes are neuromodulator cells. Their complex and dynamic morphology regulates neuronal signaling, synaptic plasticity, and neurogenesis. The impact of aging on astrocyte morphology is still under ongoing debate. Therefore, this study ...
Relation of MRI visible perivascular spaces with global and regional brain structural connectivity measures: The Framingham Heart Study (FHS) [0.03%]
磁共振成像可见的血管周围空间与全脑和区域脑结构性连接测量值的关系：弗雷明汉心脏研究(FHS)
Oluchi Ekenze,Stephan Seiler,Adlin Pinheiro et al.
Oluchi Ekenze et al.
MRI visible perivascular spaces (PVS) are associated with cognitive impairment and dementia, which are also associated with disrupted network connectivity. PVS may relate to dementia risk through disruption in brain connectivity. We studied...
Advancing age and sex modulate antidyskinetic efficacy of striatal CaV1.3 gene therapy in a rat model of Parkinson's disease [0.03%]
年龄和性别对帕金森病大鼠模型中尾状核CaV1.3基因治疗的抗异动症疗效有调节作用
Margaret E Caulfield,Molly J Vander Werp,Jennifer A Stancati et al.
Margaret E Caulfield et al.
We previously demonstrated that viral vector-mediated striatal CaV1.3 calcium channel downregulation in young adult (3mo) male parkinsonian rats provides uniform, robust protection against levodopa-induced dyskinesias (LID). Acknowledging t...
Brain activation in older adults during odor identification is related to ApoE, t-tau/Aβ1-42, and hippocampal volume [0.03%]
老年人在气味识别过程中脑激活与ApoE,t-tau/Aβ1-42和海马体积的关系
Abigail Albertazzi,Claire Murphy
Abigail Albertazzi
Despite altered odor identification preceding and predicting Alzheimer's disease (AD) cognitive decline, an inadequate understanding of how AD pathology affects odor memory functions limits its use as a preclinical biomarker. Multivariate l...
Aging of gray matter microstructure: A brain-wide characterization of, age group differences using NODDI [0.03%]
灰质微观结构的老化：使用NODDI进行大脑范围的年龄组差异特征分析
Danielle Greenman,Ilana J Bennett
Danielle Greenman
This study aimed to provide a complete characterization of age group differences in cortical lobar, hippocampal, and subcortical gray matter microstructure using a multi-compartment diffusion-weighted MRI (DWI) approach with parameters opti...
Normative aging results in degradation of gene networks in a zebra finch basal ganglia nucleus dedicated to vocal behavior [0.03%]
规范的老化导致鹧鸪基底核神经元中调控鸣叫行为的基因网络退化
Charles M Higgins,Sri Harsha Vishwanath,Fiona M McCarthy et al.
Charles M Higgins et al.
Aging increases brain susceptibility to neurodegenerative diseases, but the mechanisms are not clear. Vocal behavior provides an accessible, reliable, and sensitive biomarker to address this because voice changes in middle age can be early ...
Exploring morphological and microstructural signatures across the Alzheimer's spectrum and risk factors [0.03%]
阿尔茨海默病谱系和风险因素中的形态和微观结构特征研究
Aurélie Bussy,Raihaan Patel,Olivier Parent et al.
Aurélie Bussy et al.
Neural alterations, including myelin degeneration and inflammation-related iron burden, may accompany early Alzheimer's disease (AD) pathophysiology. This study aims to identify multi-modal signatures associated with MRI-derived atrophy and...
Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions [0.03%]
大鼠海马和副海马区与年龄相关的突触特征的脑容量和认知储备
David J Horovitz,Laura A Askins,Grace M Regnier et al.
David J Horovitz et al.
Age-related cognitive decline varies widely among individuals, with some showing resilience despite older age. This study examines synaptic markers of glutamatergic and GABAergic neurotransmission in the hippocampus and cortex of older rats...
Circulating non-esterified fatty acids, risk of dementia and cognitive decline: The cardiovascular health study and multi-ethnic study of atherosclerosis [0.03%]
循环非酯化脂肪酸与痴呆及认知衰退的风险：心血管健康研究和多民族动脉粥样硬化研究
Kristine F Moseholm,Majken K Jensen,Petra Buzkova et al.
Kristine F Moseholm et al.
Circulating non-esterified fatty acids (NEFAs) have toxic effects on a variety of organs central to cardiometabolic disease and can cross the blood-brain barrier. Whether NEFAs associate with cognitive decline or dementia remains unknown. C...