Amyloid-associated cognitive trajectories in aging dogs mirror early changes in humans [0.03%]
犬老化相关的淀粉样蛋白病理变化及其认知轨迹与人类早期变化相似
Casey R Vanderlip,Jessica N Lingad,Zoe Treadwell et al.
Casey R Vanderlip et al.
Amyloid-β (Aβ) accumulation begins many years before the onset of clinical symptoms in Alzheimer's disease (AD). Studies in humans suggest that unimpaired individuals with elevated Aβ exhibit subtle changes in cognitive trajectories over...
Sex-specificities in the association between social network and cognition in older individuals [0.03%]
社会网络与老年人认知功能关系的性别差异性研究
Déborah Farago,Célia Pinabiau,Maéva Boulin et al.
Déborah Farago et al.
Social engagement is thought to support reserve and resilience in aging, yet prior findings suggest it may relate differently, potentially even in opposite directions, in males and females. To further understand these differences, we invest...
Age-related differences in motor unit behaviours and maximal strength: A systematic review and meta-analysis [0.03%]
年龄相关的运动单元行为和最大力量的差异：系统回顾和元分析
Dagnew Getnet Adugna,Simon Walker,Oliver Hayman et al.
Dagnew Getnet Adugna et al.
Ageing is associated with a decline in strength; however, the neural mechanisms underpinning these changes remain poorly understood. Motor unit discharge rate (MUDR) and recruitment threshold (MURT) regulate the magnitude of motoneuron outp...
Subtle cortical thinning in the temporal pole in middle-aged APOE-ε4 and PICALM (rs3851179) AA/AG carriers without dementia [0.03%]
中年APOE-ε4和PICALM（rs3851179）AA/AG无痴呆患者海马旁回皮层变薄现象研究
Patrycja Dzianok,Jakub Wojciechowski,Tomasz Wolak et al.
Patrycja Dzianok et al.
The symptoms of Alzheimer's disease (AD) are caused by neurodegeneration and atrophy in particular brain regions, especially in the temporal lobe. However, the influence of genetic risk on cortical thickness prior to dementia onset, remains...
Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular alterations in the basolateral amygdala of older Veterans [0.03%]
创伤后应激障碍与老战士基底外侧杏仁核相关阿尔茨海默病分子改变有关
Macy A Seijo,Pheven A Yohannes,Amaya L Rogers et al.
Macy A Seijo et al.
Posttraumatic stress disorder (PTSD) is associated with accelerated cognitive aging and increased risk for Alzheimer's disease (AD) and related dementias (ADRD), yet the biological substrates linking trauma-related psychiatric illness to al...
Personality traits and blood-based biomarkers of neurodegeneration and astrogliosis [0.03%]
人格特征与神经退行性变和星形胶质细胞增生的血液生物标志物
Antonio Terracciano,Selin Karakose,Martina Luchetti et al.
Antonio Terracciano et al.
The personality traits neuroticism and conscientiousness are associated with the risk of clinical dementia and other neurodegenerative diseases. Less is known about the association between personality and biological markers of the underlyin...
Lipid metabolism is a key central, systemic and gut microbial feature of the decline in rat hippocampal function during middle age [0.03%]
脂质代谢是大鼠海马功能在中年时期衰退的关键的中枢性、系统性和肠微生物特征
Maria Giovanna Caruso,Sebastian Dohm-Hansen,Francisco Donoso et al.
Maria Giovanna Caruso et al.
Middle age is emerging as a turning point in brain ageing, prognostic of future cognitive health and amenable to intervention. Metabolic and proteomic differences during this period are not yet fully understood and may potentially influence...
Associations among cognitive performance, VCAM-1, and GFAP in black adults: The ARCHES study [0.03%]
VCAM-1和GFAP与黑人成年人认知表现之间的关系：ARCHES研究结果
Ramkrishna K Singh,Semere Bekena,Alexis I B Walker et al.
Ramkrishna K Singh et al.
Astrocytic injury and endothelial activation are interconnected processes within the neurovascular system that may contribute to variability in cognitive performance among cognitively unimpaired adults. Glial fibrillary acidic protein (GFAP...
Systemic infections alter cortical transcriptional signatures in Alzheimer's disease [0.03%]
系统性感染会改变阿尔茨海默病皮质转录特征
Giulia Pegoraro,Lachlan F MacBean,Adam R Smith et al.
Giulia Pegoraro et al.
Alzheimer's disease (AD) is characterized by neuroinflammation, yet the impact of concurrent systemic infections on the AD brain remains poorly understood. We investigated the molecular mechanisms underlying the central nervous system respo...
Exogenous mitochondrial transplantation attenuates oxidative stress-driven retinal degeneration in a sodium iodate - induced mouse model [0.03%]
外源线粒体移植通过减轻氧化应激诱导的小鼠视网膜退变的作用
Seok Jae Lee,Sung-Eun Noh,Jeong Hun Kim
Seok Jae Lee
Age-related macular degeneration (AMD) is a degenerative retinal disease initiated by dysfunction of the retinal pigment epithelium (RPE), in which age-related mitochondrial impairment, oxidative stress, chronic inflammation, and complement...