Frontal white matter hyperintensity burden predicts cognitive response to N-acetylcysteine and exercise in vascular mild cognitive impairment [0.03%]
frontal白质高信号负荷可预测血管性轻度认知障碍患者用N-乙酰半胱氨酸和运动治疗的认知反应
Ethan Mah,Damien Gallagher,Fuqiang Gao et al.
Ethan Mah et al.
Vascular mild cognitive impairment (vaMCI) is a prodromal stage of dementia defined by cognitive deficits due to cerebrovascular disease. Increased white matter hyperintensity (WMH) volume has been associated with reduced executive function...
Concurrent associations between visit-to-visit changes in actigraphy-based physical activity and cognitive aging in older adults [0.03%]
基于活动记录仪的体力活动变化与老年人认知衰老之间的并行关联
Ranjani P Shankar,Rowan Saloner,Coty Chen et al.
Ranjani P Shankar et al.
Physical activity (PA) is associated with lower dementia risk, yet few studies examine objectively measured PA with concurrently measured brain and cognitive aging outcomes longitudinally, leaving a gap in knowledge regarding temporality of...
Maddison L Hodgins,Selena P Maxwell,Susan E Howlett et al.
Maddison L Hodgins et al.
Frailty increasingly is recognized as a factor that modifies the relationship between disease biomarkers, including neuropathology, and dementia expression. The mechanisms underlying the relationship between frailty and dementia remain uncl...
Alpha band activity mediates age-related effects on three distinct aspects of working memory dynamics [0.03%]
阿尔法波活动调节年龄相关的三种工作记忆动态效应
Charlotte Pscherer,Moritz Mückschel,Christian Beste
Charlotte Pscherer
Working memory (WM) processes decline with increasing age. According to recent concepts, it is necessary to differentiate between dynamically changing 'WM states' which are regulated via gating mechanisms. We investigated which neural oscil...
Investigating dual-task biomarkers of subjective cognitive decline using functional near-infrared spectroscopy [0.03%]
利用功能近红外光谱法研究主观认知下降的双任务生物标志物
Talia Salzman,Diana P Tobón,Vanessa Taler et al.
Talia Salzman et al.
Older adults with subjective cognitive decline (SCD) may be at a greater risk of cognitive impairment than older adults without SCD (i.e., non-SCD). This study examined dual-task changes in cerebral oxygenation and performance to determine ...
Neuronal TrkB supports adult cortical oligodendrogenesis in the brains of older adult mice [0.03%]
成人脑中神经元TrkB支持老年小鼠皮层少突胶质细胞生成
Madeline Nicholson,Rhiannon J Wood,Simon S Murray et al.
Madeline Nicholson et al.
Lifelong oligodendrogenesis and myelination is critical for healthy brain aging. Using cumulative labelling with thymidine analogue, 5-ethynyl-2'-deoxyuridine (EdU) for 6-weeks commencing at 2-, 12- and 18-months of age in C57BL/6 mice, we ...
A timeline of structural and functional consequences to ipRGCs in a mouse model of Alzheimer's disease [0.03%]
阿尔茨海默病小鼠模型中ipRGCs的结构和功能后果的时间线
Brandy S Recio,William A Pérez,Ruth Tjondropurnomo et al.
Brandy S Recio et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects cognitive, sensory and motor systems, including the visual system and has a significant impact on autonomy and quality of life. Emerging evidence suggests tha...
Rare ABCA7 mutations in Alzheimer's disease and cerebral amyloid angiopathy pathology [0.03%]
ABCA7罕见变异在阿尔茨海默病及脑淀粉样血管病中的研究
Elisabeth Hendrickx Van de Craen,Liene Bossaerts,Anne Sieben et al.
Elisabeth Hendrickx Van de Craen et al.
Rare mutations in the ATP binding cassette subfamily A member 7 (ABCA7) gene are known risk factors for Alzheimer's disease (AD). Genetic sequencing in 1372 Belgian patients previously revealed rare ABCA7 mutations in 102 carriers, 58 with ...
Regional growth rates of white matter hyperintensities are associated with beta-amyloid burden [0.03%]
白质高信号的增长率与β淀粉样蛋白负担相关
Jeremy F Strain,Maryam Rahmani,Chia-Ling Phuah et al.
Jeremy F Strain et al.
There is increasing evidence for an association between white matter hyperintensities (WMH) and brain beta-amyloid deposition. How WMH are longitudinally associated with brain beta-amyloid burden requires further investigation, particularly...
Resting-state EEG aperiodic exponent moderates the association between age and memory performance in older adults [0.03%]
年龄与记忆表现在老年人大肠埃氏菌休息状态下的非周期指数的调节作用
Alicia J Campbell,Toomas Erik Anijärv,Mikael Johansson et al.
Alicia J Campbell et al.
Memory functions are susceptible to age-related cognitive decline, making it essential to explore the underlying neurophysiological mechanisms that contribute to memory function during healthy ageing. Resting-state EEG (rsEEG) parameters, p...