Targeting the Aryl Hydrocarbon Receptor to Attenuate IGF1R Signaling in Thyroid Eye Disease [0.03%]
靶向aryl hydrocarbon受体以减弱甲状腺眼病中的IGF1R信号传导
Elisa Roztocil,Farha Husain,Charkira C Patrick et al.
Elisa Roztocil et al.
Background: Thyroid eye disease (TED) is an autoimmune disorder characterized by proptosis, inflammation, and fibrosis. Elevated insulin-like growth factor 1 receptor (IGF1R) signaling in TED orbital fibroblasts (OFs) drives the proliferati...
Combining Ultrasound Imaging and Molecular Testing in a Multimodal Deep Learning Model for Risk Stratification of Indeterminate Thyroid Nodules [0.03%]
结合超声影像和分子检测的多模态深度学习模型对甲状腺不确定结节的风险分层研究
Shreeram Athreya,Andrew Melehy,Sujit Silas Armstrong Suthahar et al.
Shreeram Athreya et al.
Identification and Characterization of Highly Potent and Isoenzyme-Selective Inhibitors of Deiodinase Type I via a Nonradioactive High-Throughput Screening Method [0.03%]
基于非放射性高通量筛选方法鉴定和表征高效且异构酶选择性的脱碘酶I型抑制剂
Rajas Sane,Carola Seyffarth,Sabrina Kleissle et al.
Rajas Sane et al.
Objective: Deiodinase type I (DIO1) is crucial in maintaining thyroid hormone (TH) balance. It converts the prohormone thyroxine (T4) to the active triiodothyronine (T3) and degrades T3 to inactive 3,3'-diiodothyronine (3,3'-T2). It also ac...
Clinically Significant Central Lymph Node Metastasis is Not Common in Patients with Clinically N0 Papillary Thyroid Carcinoma on Both Ultrasonography and CT [0.03%]
临床上乳头状甲状腺癌患者在超声和CT检查中中央区淋巴结转移并不常见
Byung-Chang Kim,Shin Jeong Pak,Douk Kwon et al.
Byung-Chang Kim et al.
Background: The necessity of prophylactic central lymph node dissection (p-CLND) in patients with clinically node-negative papillary thyroid carcinoma (PTC) is unclear. The present study evaluated the central lymph node (LN) metastases stat...
Reproductive Factors, Sex Hormone Levels, and Differentiated Thyroid Cancer Risk: A Mendelian Randomization Study [0.03%]
生殖因素、性激素水平与分化型甲状腺癌风险：孟德尔随机化研究
See Hyun Park,Pierre-Emmanuel Sugier,Yazdan Asgari et al.
See Hyun Park et al.
Background: Differentiated thyroid carcinoma (DTC) is occurring three times more frequently in females than in males. However, the underlying biological mechanisms driving this discrepancy remain poorly understood. To investigate the causal...
Letter to Editor: "High Rates of Unnecessary Surgery for Indeterminate Thyroid Nodules in the Absence of Molecular Test and the Cost-Effectiveness of Utilizing Molecular Test in an Asian Population: A Decision Analysis" by Fung et al [0.03%]
致编辑的信：《在没有分子检测的情况下，不确定甲状腺结节高比率的不必要的手术以及在一个亚洲人群中使用分子检测的成本效果分析》-Fung等人撰写
Kennichi Kakudo,Andrey Bychkov,Jen-Fan Hang et al.
Kennichi Kakudo et al.
Sex Differences in Risk for Iatrogenic Thyrotoxicosis Among Older Adults: An Analysis from Real-World Clinical Data [0.03%]
老年患者医源性甲亢风险的性别差异分析：来自真实世界临床数据的结果
Roy Adams,Jennifer Sophie Mammen
Roy Adams
Background: Overtreatment with thyroid hormone is common and is associated with multiple adverse health outcomes, especially in older adults. Higher overtreatment rates have been reported among women. Understanding this sex difference could...