Comprehensive Analysis of DNA Methylation and Gene Expression Datasets Identified MMP9 and TWIST1 as Important Pathogenic Genes of Lung Adenocarcinoma [0.03%]
DNA甲基化和基因表达数据集的全面分析识别出MMP9和TWIST1是肺腺癌重要的致病基因
Wen Tian,Yong-Sheng Li,Jing-Hua Zhang et al.
Wen Tian et al.
Due to the high mortality of lung cancer, early diagnosis followed by early effective treatment is the key to prognosis improvement, which demands to identify the biological targets. Therefore, a multistage screening analysis was used to id...
Targeted Elimination of Peroxisomes During Viral Infection: Lessons from HIV and Other Viruses [0.03%]
靶向消除病毒的过氧化物酶体：来自人类免疫缺陷病毒及其他病毒的启示
Cheung Pang Wong,Zaikun Xu,Christopher Power et al.
Cheung Pang Wong et al.
Peroxisomes are membrane-bound organelles that are best known for their roles in lipid metabolism. Mounting evidence indicates that they are also important nodes for antiviral signaling. While research over the past few decades has revealed...
Heparanase Is a Critical Regulator of Mitotic Spindles Required for Maintaining Chromosome Stability [0.03%]
肝素酶是维持染色体稳定所必需的重要的有丝分裂纺锤体调节因子
Shuo Yang,Yong Liao,Qi Zhao et al.
Shuo Yang et al.
The mitotic spindle, assembled by microtubule organization center (MTOC), is a critical structure required for proper chromosome segregation during mitosis. Studies demonstrated that defects of mitotic spindle assembling would result in chr...
The Long Noncoding RNA TP73-AS1 Interacted with miR-124 to Modulate Glioma Growth by Targeting Inhibitor of Apoptosis-Stimulating Protein of p53 [0.03%]
长非编码RNA TP73-AS1通过靶向p53诱导的凋亡刺激蛋白与miR-124相互作用调节胶质瘤生长
Shuai Xiao,Rensheng Wang,Xiangwei Wu et al.
Shuai Xiao et al.
P73 antisense RNA 1T (non-protein coding), known as TP73-AS1 or PDAM, is a long noncoding RNA (lncRNA), which may regulate apoptosis by regulation of p53-dependent antiapoptotic genes. An abnormal change of TP73-AS1 expression was noticed i...
Carol Shoshkes Reiss
Carol Shoshkes Reiss
miR-522 Modulated the Expression of Proinflammatory Cytokines and Matrix Metalloproteinases Partly via Targeting Suppressor of Cytokine Signaling 3 in Rheumatoid Arthritis Synovial Fibroblasts [0.03%]
microRNA-522通过靶向细胞因子信号转导抑制蛋白3部分调节类风湿关节炎滑膜成纤维细胞中促炎症细胞因子和基质金属蛋白酶的表达
Xin Wang,Xuwei Si,Jiaying Sun et al.
Xin Wang et al.
microRNAs have been reported to play important roles in the pathogenesis of rheumatoid arthritis (RA). This study examined the effects of miR-522 on the biological behaviors of RA synovial fibroblasts. The expression levels of miR-522 and r...
Endoplasmic Reticulum Stress Facilitates the Survival and Proliferation of Nucleus Pulposus Cells in TNF-α Stimulus by Activating Unfolded Protein Response [0.03%]
内质网应激通过激活未折叠蛋白反应促进TNF-α刺激下椎间盘细胞的存活和增殖
Lu Chen,Lei Liu,Zhi-Yang Xie et al.
Lu Chen et al.
Intervertebral disc (IVD) degeneration is closely related to inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α). The endoplasmic reticulum (ER) serves several important cell functions, which are essential for normal cell m...
Noninvasive Prenatal Testing of Rare Autosomal Aneuploidies by Semiconductor Sequencing [0.03%]
基于半导体的测序进行罕见常染色体异常的无创产前检测
Mei-Juan Xie,Zhi-Kun Liang,Dan He et al.
Mei-Juan Xie et al.
Rare autosomal aneuploidies (RAAs) can cause miscarriage or other pregnancy complications and lead to inconsistent results of noninvasive prenatal testing (NIPT), but many NIPT providers have not yet started to provide related services. Our...
Integrin Heterodimers Expressed on the Surface of Porcine Spermatogonial Stem Cells [0.03%]
猪 spermatogonial 干细胞表面表达的整合素异二聚体
Min Hee Park,Min Seong Kim,Jung Im Yun et al.
Min Hee Park et al.
To date, in vitro culture systems able to sufficiently expand the small population of spermatogonial stem cells (SSCs), a tool for the development of sperm-mediated gene transfer techniques in transgenic pigs, in the porcine seminiferous tu...
miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling [0.03%]
microRNA-654-5p通过Ras/MAPK信号促进口腔鳞状细胞癌增殖、转移和耐药的作用及机制研究：靶向GRAP分子的功能与机制
Meng Lu,Chengyong Wang,Weihui Chen et al.
Meng Lu et al.
Oral squamous cell carcinoma (OSCC) is characterized by rapid local migration and invasion. This study was aimed at clarifying the effect of miR-654-5p on progression of OSCC. miR-654-5p promoted proliferation, metastasis, and chemoresistan...