Liquid Biopsy in Head and Neck Squamous Cell Carcinoma: A Systematic Review of the Scientific Literature [0.03%]
液体活检在头颈部鳞癌中的应用：系统综述
Tabata Briaunys Milan,Cailaine Garcia Pereira,Rafael Pereira de Souza et al.
Tabata Briaunys Milan et al.
Head and neck squamous cell carcinoma (HNSCC) presents a significant global health challenge, characterized by late-stage diagnosis and high rates of locoregional recurrence. Traditional tissue biopsy, while considered the gold standard, is...
Molecular Restoration Through Replacement Therapies: Current Advances and Future Directions in Treating Diseases [0.03%]
通过替代疗法进行分子修复：治疗疾病方面的当前进展和未来方向
Moslem Naderian,Elham Davoudi,Salar Hafez Ghoran et al.
Moslem Naderian et al.
Replacement therapy is an advanced therapeutic approach for diseases caused by molecular deficits. It aims to restore normal physiology by replacing deficient molecules such as enzymes, proteins, genes, or other molecules. Here, we discuss ...
The Single-Cell Atlas Revolution: Integrating Lineage, Space, and Evolution to Decode Animal Biology [0.03%]
单细胞图谱革命：整合谱系、空间和进化以解码动物生物学
Shahab Ur Rehman,Rahmat Ali,Hosameldeen Mohamed Husien et al.
Shahab Ur Rehman et al.
The advent of single-cell RNA sequencing (scRNA-seq) has fundamentally transformed biological research, converting our understanding of cellular diversity from a purely conceptual idea into a quantifiable, applicable, and observable reality...
Siglec-15 Enhances Cisplatin Resistance in Cervical Cancer Cells by Promoting Mitochondrial Retrograde Signaling Through Activation of the MAPK Pathway [0.03%]
SIGLEC15通过激活MAPK途径促进线粒体逆向信号传导从而增强宫颈癌细胞的顺铂抗性
Zenghui Li,Junwei Zhao,Li Hao et al.
Zenghui Li et al.
Chemoresistance constitutes a major cause of poor prognosis in advanced cervical cancer. Our previous studies have confirmed that Siglec-15 affects the progression of cervical cancer, whereas its role in regulating cervical cancer chemoresi...
The Potential Role and Mechanism of RBM47-Mediated Genes in Atherosclerosis [0.03%]
RBM47介导的基因在动脉粥样硬化中的潜在作用及机制研究
Jing Hu,Chunling Ren,Wujun Chen et al.
Jing Hu et al.
RNA-binding motif 47 (RBM47), a hub gene in atherosclerosis, induced oxidative stress in macrophages in atherosclerosis progression by enhancing ENC1 stability via binding to the AU-rich elements (AREs). However, RBM47 promoted C-to-U editi...
From Single Cytokines to Networks: A Systems Immunology View of Ulcerative Colitis [0.03%]
从单一细胞因子到网络：系统免疫学视角下的溃疡性结肠炎
Marton Olbei,John P Thomas,Tamas Korcsmaros et al.
Marton Olbei et al.
Ulcerative colitis (UC) is a chronic immune-mediated disorder of the gastrointestinal tract underpinned by dysregulated mucosal immune responses. Although biological therapies targeting individual cytokines have improved clinical outcomes, ...
Fibroblast Growth Factor 18 Regulates Mitochondrial Function to Alleviate Myocardial Ischemia-Reperfusion Injury in Rats [0.03%]
成纤维细胞生长因子18通过调节线粒体功能减轻大鼠心肌缺血再灌注损伤的作用及机制研究
Haijiao Yang,Guanglei He,Xiaojing Cui et al.
Haijiao Yang et al.
The purpose of this work was to examine the function of fibroblast growth factor 18 (FGF18) in rat myocardial ischemia-reperfusion injury (MIRI) and elucidate its relationship to mitochondrial function through the Sirtuin 1/peroxisome proli...
Silencing Long Noncoding RNA CRNDE Alleviates Hypoxia-Induced Myocardial Cell Injury by Inhibiting the NLRP3/ASC Pathway [0.03%]
长链非编码RNA CRNDE通过抑制NLRP3/ASC途径缓解缺氧诱导的心肌细胞损伤
Zhenwei Xu,Yayi Huang,Hebin Chen et al.
Zhenwei Xu et al.
Myocardial ischemia-induced cell injury involves the concurrent occurrence of pyroptosis, apoptosis, and oxidative stress, whereas its upstream regulatory mechanism remains unclear. The present study aimed to investigate the functional asso...
Integrated Multi-Omics Profiling Reveals Coordinated Transcriptional, Translational, and Metabolic Remodeling in IPF Fibroblasts [0.03%]
整合多组学分析揭示IPF成纤维细胞中协调的转录、翻译和代谢重塑
Min Kyung Kim,Eun Jeong Seo,Seung-Lee Park et al.
Min Kyung Kim et al.
Idiopathic pulmonary fibrosis (IPF) is characterized by persistent fibroblast activation and progressive extracellular matrix remodeling, leading to irreversible lung architectural distortion. Although high-throughput omics approaches have ...
The Innate Immune Protein IFITM3 as a γ-Secretase Modulatory Protein: From Inflammation to Alzheimer's Disease [0.03%]
innate免疫蛋白IFITM3作为γ-分泌酶调节蛋白：从炎症到阿尔茨海默病
Jee-Soo Choi,Ji-Yeun Hur
Jee-Soo Choi
The mechanisms of Alzheimer's disease (AD) development are complex, and the detailed roles of neuroinflammation in AD still need to be elucidated. With various genetic and environmental risk factors, the accumulation of harmful amyloid plaq...