Silent Signals: The Expanding Role of Cell-Free DNA in Women's Health, Pregnancy, and Reproductive Medicine [0.03%]
无言的信号：细胞-free DNA在女性健康、妊娠和生殖医学中的作用日益重要
Matin Dolatabadi,Mahdieh Mondanizadeh
Matin Dolatabadi
Cell-free DNA (cfDNA) is an emerging biomarker detectable in various bodily fluids, with promising implications across a wide range of clinical domains. Its minimally invasive nature, short half-life, and ability to reflect tissue-specific ...
Compensatory Gene Regulation Following Survivin Inhibition in MDA-MB-231 Cells [0.03%]
survivin抑制后MDA-MB-231细胞中的补偿性基因调节作用
Manuel Antonio Martínez-Sifuentes,Juan Ramos-Treviño,Magali Espinosa-Castilla et al.
Manuel Antonio Martínez-Sifuentes et al.
Breast cancer is the most diagnosed cancer in women and the second leading cause of cancer-related mortality worldwide. Advances in genetic technology have highlighted the heterogeneity of breast cancer, composed of various biological subty...
First-in-Class Small Molecule Inhibitor of Oncogene AVIL in Glioblastoma [0.03%]
针对胶质母细胞瘤癌基因AVIL的首创新型小分子抑制剂
Zhongqiu Xie,Sophia Xie,Hui Li
Zhongqiu Xie
Glioblastoma multiforme (GBM) is the most prevalent and aggressive malignant primary brain tumor, marked by rapid growth, extensive invasiveness, and a median survival of only ∼15 months despite current multimodal therapy. To identify new ...
Dietary Saturated Fatty Acids as Evolutionarily Conserved Signals of Immune Activation [0.03%]
饱和脂肪酸作为进化上保守的免疫激活信号
Sam J McCright,Olivia Harding,David A Hill
Sam J McCright
Dietary fat is comprised largely of fatty acids (FAs), which function not only as metabolic substrates but also as key intracellular signaling molecules. Saturated fatty acids (SFAs) have long been linked to metabolic and inflammatory disea...
Carla E M Golden,Christine M Constantinople
Carla E M Golden
Estrogenic hormones act throughout the brain, yet the basic mechanisms by which hormones influence neural circuit dynamics and computations, especially during complex behaviors, are unclear. Exogenous estrogenic hormones modulate dopamine s...
Impact of FTO Genetic Variants on Colorectal Cancer Risk: A Case-Control Study [0.03%]
FTO基因多态性与结直肠癌发病风险的相关性研究——一项病例对照研究
Zimo Yan,Xianlei Zhou,Wenlong Wu et al.
Zimo Yan et al.
This study aimed to assess the association between fat mass and obesity-associated (FTO) genetic variants and colorectal cancer (CRC) risk in a retrospective case-control cohort. FTO expression in CRC versus normal tissues was analyzed via ...
N6-Methylation Modification: Its Role in Regulating Cell Senescence and Inflammation in Osteoarthritis and Intervertebral Disc Degeneration [0.03%]
N6-甲基化修饰在骨关节炎和椎间盘退变中的作用机制研究进展
Rui Sun,Yan Zhou,Xiao-Tao Wu et al.
Rui Sun et al.
N6-methyladenosine (m6A) methylation, the most prevalent internal mRNA modification in eukaryotes, plays a crucial role in regulating various biological processes. Recent advancements reveal its significant involvement in osteoarthritis (OA...
Ubiquitin-Specific Proteases in Breast Cancer: Unraveling Oncogenic Roles and Therapeutic Opportunities [0.03%]
泛素特异性蛋白酶在乳腺癌中的致癌作用及治疗机会研究
Jitendra Gupta,Nisreen Salah Majeed,Mudhr Kedhem et al.
Jitendra Gupta et al.
The ubiquitin-proteasome system (UPS) is a crucial determinant of protein stability and activity in various aspects of physiological function and disease development. The well-characterized class of regulatory enzymes within the UPS is deub...
Integrative Analysis of miRNA and CpG Methylation with the Transcriptome of Lung-Derived Fibroblasts Identifies Epigenetically Regulated Genes in Idiopathic Pulmonary Fibrosis [0.03%]
整合分析肺来源成纤维细胞的miRNA和CpG甲基化与转录组鉴定特发性肺纤维化的表观遗传调控基因
Min Kyung Kim,Jung Hyun Kim,Hun Gyu Hwang et al.
Min Kyung Kim et al.
Idiopathic pulmonary fibrosis (IPF) arises from interactions between genetic predisposition and environmental exposures (exposome). This study used an integrative multi-omics to identify co-regulated genes in IPF fibroblasts. Differentially...
MAPK Signaling and the Tumor Microenvironment: Drivers of Cancer Development and Resistance [0.03%]
MAPK信号和肿瘤微环境：癌症发生和发展耐药性的驱动因素
Hamza Abu Owida,Suleiman Ibrahim Mohammad,Pareshkumar N Patel et al.
Hamza Abu Owida et al.
The mitogen-activated protein kinase (MAPK) signaling pathway plays a key role in regulating a number of cellular processes, including proliferation, differentiation, apoptosis, and cellular responses to stress. In cancer, abnormal activati...