The Role of LncRNA ANRIL in Hepatocellular Carcinoma Tumorigenesis: Regulation of the p53 Signaling Pathway [0.03%]
长链非编码RNA ANRIL在肝细胞癌发生中的作用：对p53信号通路的调控
Jieting Liu,Minglu Ding,Ping He et al.
Jieting Liu et al.
The long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL) expression is upregulated in hepatocellular carcinoma (HCC) tissues, and decreased ANRIL expression inhibits cell proliferation, metastasis, and invasion and ...
RNPS1 Promotes the Progression of Nonsmall Cell Lung Cancer via ETV4-Mediated Ferroptosis [0.03%]
RNPS1通过ETS转录因子ETV4介导的铁死亡促进非小细胞肺癌进展
Lingling Wang,Shitao Mao,Yue Sun et al.
Lingling Wang et al.
Ferroptosis plays a crucial role in regulating tumor growth and represents a promising therapeutic target for nonsmall cell lung cancer (NSCLC). RNA-binding protein with serine-rich domain 1 (RNPS1) has been closely associated with the deve...
Qingqing Yang,Yunpeng Zhao,Li Zhu et al.
Qingqing Yang et al.
Copper plays an essential role in numerous biological functions, requiring tight regulation to prevent toxicity and health complications. Cuproptosis is a recently discovered form of regulated cell death that occurs due to intracellular cop...
Ferroptosis Profiles of Human Mesenchymal Stromal Cell Subsets at the Single-Cell Level [0.03%]
人基质细胞亚群单细胞水平的铁死亡图谱
Xin Wen,Shuai Ding,Yujie Zhou et al.
Xin Wen et al.
Mesenchymal stromal cells (MSCs) have been widely used in clinical trials for various diseases, due to their broad differentiation potential and effective immunomodulatory effects. However, the cell death profiles of MSC subsets remain inad...
Mesenchymal Stem Cells Preconditioned with Herbal Bioactive Components: Exosome-Mediated microRNA Mechanisms and Therapeutic Potential for Chronic Kidney Disease [0.03%]
中药活性成分预处理的间充质干细胞：外泌体介导的microRNA机制及慢性肾脏病治疗潜能
Lili Lu,Zheng Zhang,Jian Liu et al.
Lili Lu et al.
The development of effective therapeutic strategies for chronic kidney disease (CKD) remains a central focus of contemporary medical research. Mesenchymal stem cells (MSCs) have emerged as a highly promising therapeutic modality for CKD, pr...
LncRNA Gm17586 Reduces HSCs Activation by Increasing SIRT1 Transcript Activity to Enhance Smad3 Deacetylation [0.03%]
Gm17586 lncRNA通过增加SIRT1的转录活性促进Smad3去乙酰化从而减少HSC激活的功能研究
Linhui Zhang,Huimei Chen,Xue Pang et al.
Linhui Zhang et al.
Long noncoding RNAs (lncRNAs) play crucial roles in liver fibrosis (LF). We previously showed that the key lncRNA Gm17586 is involved in LF, but its molecular mechanism remains unclear. Primary hepatic stellate cells (HSCs) were isolated fr...
Anuma Pallavi,Nikhil R Gandasi
Anuma Pallavi
Glucose homeostasis is an essential physiological process to ensure a stable energy supply to all tissues while preventing the harmful consequences of hypo- or hyperglycemia. The endocrine pancreas plays a central role in maintaining this p...
USP26 Promotes Cell Proliferation of Gastric Cancer by Stabilizing c-Myc [0.03%]
USP26通过稳定c-Myc促进胃癌细胞增殖
Doudou Ren,Zeqiong Cai,Ru Zhang et al.
Doudou Ren et al.
Gastric cancer is one of the leading causes of cancer mortality worldwide, but the underlying molecular mechanisms by which gastric cancer progresses are not fully understood. While deubiquitinases have emerged as promising therapeutic targ...
Mechanisms and Opportunities of the Arrestin Beta Signaling Pathway in Liver Diseases [0.03%]
β肾上腺素能受体阻断剂的肝脏保护作用及其机制研究进展
Wenchao Zhou,Hong Xia,Tian Zeng et al.
Wenchao Zhou et al.
Arrestin beta 1 (ARRB1) and ARRB2, which are multifunctional adapters in G protein-coupled receptor signaling, are highly involved in liver-related diseases. ARRB1 plays a protective role against ischemia-reperfusion injury, acute liver inj...
Subtype-Specific Noncoding Ribonucleic Acid Signatures in Gastric Cancer: Insights from The Cancer Genome Atlas-Based Classification [0.03%]
基于TCGA分型的胃癌非编码核糖核酸亚型特征研究
Mohsen Sharif-Zak,Omid Dehqani Dashtabi,Fatemeh Binayi et al.
Mohsen Sharif-Zak et al.
Gastric cancer (GC) is the fifth most common malignancy and one of the leading causes of cancer-related death worldwide. Its histological and molecular heterogeneity make it particularly challenging to manage. The Cancer Genome Atlas classi...