Anuma Pallavi,Nikhil R Gandasi
Anuma Pallavi
Glucose homeostasis is an essential physiological process to ensure a stable energy supply to all tissues while preventing the harmful consequences of hypo- or hyperglycemia. The endocrine pancreas plays a central role in maintaining this p...
USP26 Promotes Cell Proliferation of Gastric Cancer by Stabilizing c-Myc [0.03%]
USP26通过稳定c-Myc促进胃癌细胞增殖
Doudou Ren,Zeqiong Cai,Ru Zhang et al.
Doudou Ren et al.
Gastric cancer is one of the leading causes of cancer mortality worldwide, but the underlying molecular mechanisms by which gastric cancer progresses are not fully understood. While deubiquitinases have emerged as promising therapeutic targ...
Mechanisms and Opportunities of the Arrestin Beta Signaling Pathway in Liver Diseases [0.03%]
β肾上腺素能受体阻断剂的肝脏保护作用及其机制研究进展
Wenchao Zhou,Hong Xia,Tian Zeng et al.
Wenchao Zhou et al.
Arrestin beta 1 (ARRB1) and ARRB2, which are multifunctional adapters in G protein-coupled receptor signaling, are highly involved in liver-related diseases. ARRB1 plays a protective role against ischemia-reperfusion injury, acute liver inj...
Subtype-Specific Noncoding Ribonucleic Acid Signatures in Gastric Cancer: Insights from The Cancer Genome Atlas-Based Classification [0.03%]
基于TCGA分型的胃癌非编码核糖核酸亚型特征研究
Mohsen Sharif-Zak,Omid Dehqani Dashtabi,Fatemeh Binayi et al.
Mohsen Sharif-Zak et al.
Gastric cancer (GC) is the fifth most common malignancy and one of the leading causes of cancer-related death worldwide. Its histological and molecular heterogeneity make it particularly challenging to manage. The Cancer Genome Atlas classi...
Nucleosome Linker Length and Distribution as Major Players in Epigenetic Regulation: Insights from Cryo-Electron Microscopy and Modeling of Retina Cell Maturation [0.03%]
基于冷冻电子显微镜和视网膜细胞成熟建模对表观遗传调控的研究：核小体连接子长度和分布起主要作用
Tamar Schlick,Sergei Grigoryev
Tamar Schlick
We summarize recent findings on the conformational differences of chromatin fibers in immature versus mature retina cells due to different nucleosome linker length values and distributions, as revealed by cryo-electron microscopy and modeli...
m6A Modification Destabilizes Prss8 and Activates Hepatic Stellate Cells via TLR4-Mediated Inflammatory Responses [0.03%]
m6A修饰通过TLR4介导的炎症反应降低Prss8并激活肝星状细胞
Huimei Chen,Linhui Zhang,Lili Zhang et al.
Huimei Chen et al.
The 6-methyladenine (m6A) modification plays a major role in various diseases. Serine protease 8 (Prss8) contributes to the initiation and progression of liver fibrosis (LF). However, the mechanism by which the m6A modification of Prss8 ind...
KIAA1429 Induces the Tumorigenesis of Clear Cell Renal Cell Carcinoma via Regulating the N6-Methyladenosine Modification of Thymosin Beta-10 [0.03%]
KIAA1429通过调节胸腺素β10的N6甲基腺苷修饰诱导透明细胞肾细胞癌的发生发展
Sheng Jin,Fang Liu
Sheng Jin
N6-Methyladenosine (m6A) is a reversible RNA modification that regulates tumorigenesis. KIAA1429, a critical component of the m6A methyltransferase complex, has an unclear role in clear cell renal cell carcinoma (ccRCC). Here, we investigat...
New Insights into Host Genetic Ancestry as a Risk Factor for Dengue Disease [0.03%]
新的关于宿主遗传祖先作为登革热发病风险因素的见解
Simon M Barratt-Boyes,Priscila M S Castanha
Simon M Barratt-Boyes
Dengue is the most important mosquito-borne viral infection of humans worldwide. Genetic ancestry of the host is a significant risk factor for severe dengue, but the mechanisms are not known. Recent findings using human skin explants from g...
Sourabh Soni,Yohannes A Mebratu
Sourabh Soni
This essay focuses on a key host factor, the protein BIK (Bcl-2-interacting killer), that influences the severity of influenza A virus (IAV) infections. Our recent research published in Proceedings of the National Academy of Sciences descri...