Fibroblast Growth Factor 18 Regulates Mitochondrial Function to Alleviate Myocardial Ischemia-Reperfusion Injury in Rats [0.03%]
成纤维细胞生长因子18通过调节线粒体功能减轻大鼠心肌缺血再灌注损伤的作用及机制研究
Haijiao Yang,Guanglei He,Xiaojing Cui et al.
Haijiao Yang et al.
The purpose of this work was to examine the function of fibroblast growth factor 18 (FGF18) in rat myocardial ischemia-reperfusion injury (MIRI) and elucidate its relationship to mitochondrial function through the Sirtuin 1/peroxisome proli...
Silencing Long Noncoding RNA CRNDE Alleviates Hypoxia-Induced Myocardial Cell Injury by Inhibiting the NLRP3/ASC Pathway [0.03%]
长链非编码RNA CRNDE通过抑制NLRP3/ASC途径缓解缺氧诱导的心肌细胞损伤
Zhenwei Xu,Yayi Huang,Hebin Chen et al.
Zhenwei Xu et al.
Myocardial ischemia-induced cell injury involves the concurrent occurrence of pyroptosis, apoptosis, and oxidative stress, whereas its upstream regulatory mechanism remains unclear. The present study aimed to investigate the functional asso...
Integrated Multi-Omics Profiling Reveals Coordinated Transcriptional, Translational, and Metabolic Remodeling in IPF Fibroblasts [0.03%]
整合多组学分析揭示IPF成纤维细胞中协调的转录、翻译和代谢重塑
Min Kyung Kim,Eun Jeong Seo,Seung-Lee Park et al.
Min Kyung Kim et al.
Idiopathic pulmonary fibrosis (IPF) is characterized by persistent fibroblast activation and progressive extracellular matrix remodeling, leading to irreversible lung architectural distortion. Although high-throughput omics approaches have ...
The Innate Immune Protein IFITM3 as a γ-Secretase Modulatory Protein: From Inflammation to Alzheimer's Disease [0.03%]
innate免疫蛋白IFITM3作为γ-分泌酶调节蛋白：从炎症到阿尔茨海默病
Jee-Soo Choi,Ji-Yeun Hur
Jee-Soo Choi
The mechanisms of Alzheimer's disease (AD) development are complex, and the detailed roles of neuroinflammation in AD still need to be elucidated. With various genetic and environmental risk factors, the accumulation of harmful amyloid plaq...
Glycosyltransferases as Oncogenic Drivers: Lessons from Cancer Genome Mining [0.03%]
糖基转移酶作为致癌驱动因子：来自癌症基因组挖掘的启示
Pranoy Sahu,Francesco Russo,Domenico Russo et al.
Pranoy Sahu et al.
Glycosylation, the enzymatic addition of sugar chains to proteins and lipids, is the most abundant and chemically diverse form of post-translational modification in eukaryotes. Despite its central role in cell biology, the glycosylation mac...
Essential Role for XRCC1 and PARP1 in the Repair of Genotoxic Damage During Spermatogenesis [0.03%]
BRCA2在生殖细胞基因毒性损伤修复中的作用机制研究
Emad A Ahmed
Emad A Ahmed
X-ray repair cross-complementing protein 1 (XRCC1) protects cells from the effects of genotoxic stress by coordinating base excision repair (BER) and DNA single-strand break repair. XRCC1 phosphorylation and recruitment to sites of DNA dama...
Identification of Lipid Metabolism-Related Gene GM2A as a Potential Biomarker in Atopic Dermatitis by Combining Weighted Gene Co-Expression Network Analysis and Machine Learning [0.03%]
结合加权基因共表达网络分析和机器学习鉴定特应性皮炎相关脂质代谢相关基因GM2A作为潜在生物标志物
Lin Wang,Yan-Hong Mao,Li-Tao Zhang
Lin Wang
Lipid metabolism is abnormal in patients with atopic dermatitis (AD). This study aimed to screen lipid metabolism-related gene (LMRG) in AD, providing insights into the underlying mechanisms of lipid metabolism abnormalities in AD. Gene exp...
SUMOylation in Neural Health and Disease: From Cellular Homeostasis to Neurodegeneration [0.03%]
神经苏木化：从细胞稳态到神经退行性疾病的机制研究
Ghaleb Oriquat,Ihsan K Jasim,Tushar B Gajjar et al.
Ghaleb Oriquat et al.
Neurodegenerative diseases (NDDs) represent a growing global health burden, particularly in aging populations. These disorders primarily affect neurons and are characterized by progressive neuronal dysfunction and loss within specific regio...
Midbody Remnants as Signaling Centers in Cell Fate Determination and Tumorigenesis [0.03%]
细胞命运决定和肿瘤发生中的胞间桥遗迹作为信号中心
Hongbin Li,Xiaoli Ma,Jing Liang et al.
Hongbin Li et al.
During final cell division, the cleaved midbody is either released or asymmetrically retained as a midbody remnant (MBR). MBRs play critical roles in cell communication, signal transduction, and translation regulation, influencing cellular ...
SLC25A30 Regulates Mitochondrial Autophagy Through the PINK1/PARKIN Signaling Pathway to Alleviate Sepsis-Associated Acute Kidney Injury [0.03%]
SLC25A30通过PINK1/PARKIN信号通路调节线粒体自噬以缓解脓毒症相关急性肾损伤
Mingyu Xu,Yuchen Wang,Wuyang Lv et al.
Mingyu Xu et al.
This study aims to investigate the expression of the SLC25 subfamily in sepsis-associated acute kidney injury (SA-AKI) and the role of SLC25A30 in regulating PINK1/PARKIN-mediated mitophagy. Transcriptome sequencing of renal tissues from li...