Identification of Lipid Metabolism-Related Gene GM2A as a Potential Biomarker in Atopic Dermatitis by Combining Weighted Gene Co-Expression Network Analysis and Machine Learning [0.03%]
结合加权基因共表达网络分析和机器学习鉴定特应性皮炎相关脂质代谢相关基因GM2A作为潜在生物标志物
Lin Wang,Yan-Hong Mao,Li-Tao Zhang
Lin Wang
Lipid metabolism is abnormal in patients with atopic dermatitis (AD). This study aimed to screen lipid metabolism-related gene (LMRG) in AD, providing insights into the underlying mechanisms of lipid metabolism abnormalities in AD. Gene exp...
SUMOylation in Neural Health and Disease: From Cellular Homeostasis to Neurodegeneration [0.03%]
神经苏木化：从细胞稳态到神经退行性疾病的机制研究
Ghaleb Oriquat,Ihsan K Jasim,Tushar B Gajjar et al.
Ghaleb Oriquat et al.
Neurodegenerative diseases (NDDs) represent a growing global health burden, particularly in aging populations. These disorders primarily affect neurons and are characterized by progressive neuronal dysfunction and loss within specific regio...
Midbody Remnants as Signaling Centers in Cell Fate Determination and Tumorigenesis [0.03%]
细胞命运决定和肿瘤发生中的胞间桥遗迹作为信号中心
Hongbin Li,Xiaoli Ma,Jing Liang et al.
Hongbin Li et al.
During final cell division, the cleaved midbody is either released or asymmetrically retained as a midbody remnant (MBR). MBRs play critical roles in cell communication, signal transduction, and translation regulation, influencing cellular ...
SLC25A30 Regulates Mitochondrial Autophagy Through the PINK1/PARKIN Signaling Pathway to Alleviate Sepsis-Associated Acute Kidney Injury [0.03%]
SLC25A30通过PINK1/PARKIN信号通路调节线粒体自噬以缓解脓毒症相关急性肾损伤
Mingyu Xu,Yuchen Wang,Wuyang Lv et al.
Mingyu Xu et al.
This study aims to investigate the expression of the SLC25 subfamily in sepsis-associated acute kidney injury (SA-AKI) and the role of SLC25A30 in regulating PINK1/PARKIN-mediated mitophagy. Transcriptome sequencing of renal tissues from li...
The Impact of Homeopathic Medicines on Dental Stem Cells: An Experimental Study [0.03%]
家用药物对牙髓干细胞的影响：一项实验研究
Marli Cristina Pereira,Thainá Beatriz Soares,Jeferson Luis de Oliveira Stroparo et al.
Marli Cristina Pereira et al.
This study investigated the influence of homeopathic medicines (HMs) on the in vitro behavior of stem cells from human exfoliated deciduous teeth (SHED). The HMs Symphytum officinale (SO), Calcarea carbonica (CC), and Calcarea phosphorica (...
Intervention Study on the Regulation of circAno6/miR-296-3p/TLR4 Signaling Axis by Shugan Jianpi Formula to Alleviate Inflammation Cascade and Inhibit HSC Activation [0.03%]
舒肝健脾方调节circAno6/miR-296-3p/TLR4信号轴干预肝纤维化的实验研究
Qian Wu,Tingting Li,Jing Qu et al.
Qian Wu et al.
Liver fibrosis (LF) is a fibrotic and inflammatory condition resulting from chronic liver damage, and the activation of hepatic stellate cells (HSCs) is the central event. Our prior research has revealed that the circAno6/miR-296-3p/Toll-li...
Dent Disease 1 Associated with a Rare Novel Renal Chloride Channel 5 Variant in a Chinese Family [0.03%]
一中国家系罕见的新肾氯通道CLCN5突变导致的 Dent病1病例报告
Si-Yuan Zhang,Hao Huang,Zi-Jie Yu et al.
Si-Yuan Zhang et al.
Dent disease 1, an X-linked recessive proximal tubulopathy most commonly caused by CLCN5 variants, often presents with heterogeneous and nonspecific phenotypes that hinder clinical diagnosis in the absence of molecular data. We investigated...
Beyond the Tumor Mass: From Initiating Clones to Overt Isocitrate Dehydrogenase-Mutant Gliomas [0.03%]
超越肿瘤实质：IDH突变型胶质瘤从启动克隆到明确诊断的发展过程
Jung Won Park,Jeong Ho Lee,Seok-Gu Kang
Jung Won Park
Isocitrate dehydrogenase (IDH)-mutant gliomas are primary malignant brain tumors defined by recurrent mutations in IDH1/2 genes and characterized by distinct molecular subtypes and relatively favorable clinical outcomes. Although these muta...
An Assembly of the Global Phosphoproteomic Network of an Underexplored Kinase CDK17: Possible Implications in Cell Cycle Regulation [0.03%]
一个未被充分研究的蛋白激酶CDK17的全球磷酸蛋白质组网络汇集分析及其对细胞周期调控的意义探讨
Ashika Bangera,Fathimathul Lubaba,Athira Perunelly Gopalakrishnan et al.
Ashika Bangera et al.
Cyclin-dependent kinase 17 (CDK17) is an understudied member of the PCTAIRE family of CDKs, with phosphorylation-guided molecular mechanism being underexplored. In this study, an in-depth mass spectrometry-based phosphoproteomics data integ...