Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway [0.03%]
生物碱姜黄素通过抑制VEGF/VEGFR2信号通路调节NSCLC的生长和迁移
Xianghong Lai,Yan Li,Miao Gao
Xianghong Lai
Non-small cell lung cancer (NSCLC) is the most common lung cancer with 15.9% of predicted 5-year survival rate which represents extremely poor prognosis. In this study, we aimed to investigate the effects of Biochanin A (BIO-A) on NSCLC bot...
GSK-3β Promotes Cell Migration and Inhibits Autophagy by Mediating the AMPK Pathway in Breast Cancer [0.03%]
GSK-3β通过介导AMPK通路促进乳腺癌细胞迁移并抑制自噬
Lu Guo,Duankai Chen,Xing Yin et al.
Lu Guo et al.
GSK-3β is a versatile protein kinase participating in many reactions. Currently, there is insufficient understanding of its influence on breast cancer (BC). In order to explore its influence on migration and invasion in BC, we investigated...
Efficacy and Safety of CalliSpheres® Drug-Eluting Beads Transarterial Chemoembolization in Barcelona Clinic Liver Cancer Stage C Patients [0.03%]
CalliSpheres药物洗脱球囊肝动脉化疗栓塞治疗巴塞罗那肝癌C期患者的疗效和安全性
Yaohong Liu,Wensou Huang,Mingji He et al.
Yaohong Liu et al.
This study aimed to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Barcelona Clinic Liver Cancer (BCLC) stage C liver cancer patients. In 39 patients with BCLC stage C liver...
Apatinib Plus Chemotherapy Shows Clinical Activity in Advanced NSCLC: A Retrospective Study [0.03%]
阿帕替尼联合化疗治疗晚期NSCLC的临床活性：一项回顾性研究
Jing Tang,Xu Yong Li,Jing Bo Liang et al.
Jing Tang et al.
Apatinib is an oral TKI with antiangiogenic properties, and it is currently approved for the treatment of advanced gastric cancer in China. This agent has also been tested in other human solid tumors, including non-small cell lung cancer (N...
Regorafenib-Induced Hand-Foot Skin Reaction Is More Severe on the Feet Than on the Hands [0.03%]
瑞戈非尼所致的手足皮肤反应以下肢更严重
Yuma Nonomiya,Takashi Yokokawa,Kazuyoshi Kawakami et al.
Yuma Nonomiya et al.
Regorafenib is a multikinase inhibitor for the treatment of metastatic colorectal cancer. Regorafenib-induced hand-foot skin reaction (HFSR) is a common side effect during treatment. The reported frequency of HFSR was 80% (grade 3: 28%) in ...
The Biological Function of Hepatitis B Virus X Protein in Hepatocellular Carcinoma [0.03%]
乙型肝炎病毒X蛋白在肝癌中的生物学功能
Qiaodong Xu,Songgang Gu,Jiahong Liang et al.
Qiaodong Xu et al.
Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a significant factor that...
Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide [0.03%]
bufalin诱导人类胶质瘤干细胞样细胞凋亡并提高其对替莫唑胺的敏感性
Jia Liu,Ying Zhang,Shulan Sun et al.
Jia Liu et al.
Glioma is the most common malignant tumor of the central nervous system, and it is characterized by high relapse and fatality rates and poor prognosis. Bufalin is one of the main ingredients of Chan-su, a traditional Chinese medicine (TCM) ...
NLRP3 Promotes Glioma Cell Proliferation and Invasion via the Interleukin-1β/NF-κB p65 Signals [0.03%]
NLRP3通过介导IL-1β/NF-κB p65信号通路促进胶质瘤细胞增殖和侵袭
Liping Xue,Bin Lu,Bibo Gao et al.
Liping Xue et al.
Because of the characteristics of high invasiveness, relapse, and poor prognosis, the management of malignant gliomas has always been a great challenge. Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) is a crucial component...
Kaempferol Suppresses Proliferation and Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Breast Cancer Cells [0.03%]
山柰酚通过细胞周期阻滞、凋亡和DNA损伤抑制乳腺癌细胞增殖
Li Zhu,Lijun Xue
Li Zhu
Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast cancer (BC), and ...
Safety and efficacy analysis of DEB-TACE treatment in elderly patients with hepatocellular carcinoma: a comparative cohort study [0.03%]
药物洗脱微球载药射频肿瘤消融治疗老年期肝癌患者的安全性和有效性分析：队列研究
Qing Yang,Xiaosheng Jin,Fangpeng Ye et al.
Qing Yang et al.
The aim of this study was to explore the difference of liver function change, safety profiles and efficacy of drug-eluting bead transarterial chemoembolization (DEBTACE) therapy between elderly and middle-aged hepatocellular carcinoma (HCC)...