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Regorafenib-Induced Hand-Foot Skin Reaction Is More Severe on the Feet Than on the Hands

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Regorafenib is a multikinase inhibitor for the treatment of metastatic colorectal cancer. Regorafenib-induced hand-foot skin reaction (HFSR) is a common side effect during treatment. The reported frequency of HFSR was 80% (grade 3: 28%) in the Japanese subpopu... ...