Research Advances in Drug Resistance Mechanisms to Anti-HER2 Therapy in HER2-Positive Breast Cancer [0.03%]
乳腺癌HER2阳性患者抗HER2治疗耐药机制的研究进展
Chunwei Huang,Jingyi Kong,Hangxing Ren et al.
Chunwei Huang et al.
HER2-positive breast cancer accounts for 15-20% of all breast cancer cases. Although the development of monoclonal antibodies (e.g., trastuzumab, pertuzumab), tyrosine kinase inhibitors (e.g., lapatinib, pyrotinib), and antibody-drug conjug...
Real-World Experience with Venetoclax Therapeutic Drug Monitoring in Acute Myeloid Leukemia: Role of Posaconazole, Correlation with Safety and Efficacy [0.03%]
维奈克拉治疗急性髓系白血病的临床经验：泊沙康唑的影响及安全性与有效性的关联研究
Beatrice Sani,Alessandro Cignetti,Marta Leporati et al.
Beatrice Sani et al.
Objectives: Venetoclax (VEN) is approved for acute myeloid leukemia (AML) in association with azacitidine, in a 28-day schedule at a fixed dosage, which requires reduction if azoles are co-administered. The present study aims to evaluate VE...
Targeting PCNA in Cancer: A Paradigm Shift from Static Inhibition to Dynamic Network Modulation [0.03%]
靶向PCNA进行癌症治疗：从静态抑制到动态网络调节的范式转变
Shijia Lu,Yanmin Wang,Han Zhang et al.
Shijia Lu et al.
Proliferating Cell Nuclear Antigen (PCNA) is a core protein in DNA replication and repair. Its functional dysregulation drives tumorigenesis and therapeutic resistance, making it a critical anticancer target. However, the fundamental confli...
Navigating the Metabolic-Genomic Paradigm: Mitochondrial Reprogramming as a Driver of Cancer Plasticity [0.03%]
代谢基因组学范式下的肿瘤细胞可塑性与线粒体功能重塑的关系研究
Yen-Dun Tony Tzeng,Chen-Yueh Wen,Su-Boon Yong et al.
Yen-Dun Tony Tzeng et al.
Breast cancer (BC) management has transitioned from histological classification to molecular subtyping, yet therapeutic resistance and intratumor heterogeneity remain critical clinical challenges. This review examines the emerging paradigm ...
Cardiac Metastasis from Poorly Differentiated Thyroid Carcinoma: A Rare Case Report and Review of the Literature [0.03%]
分化差的甲状腺癌心脏转移一例并文献复习
Xin Qian,Xian Deng,Rongjia Zhang et al.
Xin Qian et al.
Background: Poorly differentiated thyroid carcinoma (PDTC) is a rare, aggressive malignancy. Cardiac metastasis from PDTC is exceedingly uncommon. We report early cardiac metastasis occurring shortly after radical thyroidectomy to highlight...
Extracellular Signal-Regulated Kinase and Reactive Oxygen Species Regulate PD-L1 to Promote Migration and Proliferation of Triple-Negative Breast Cancer MDA-MB-231 Cells [0.03%]
细胞外信号调节激酶和活性氧通过调节PD-L1促进三阴性乳腺癌MDA-MB-231细胞迁移和增殖
Ching-Chun Ho,Yen-Cheng Chen,Wei-Liang Lean et al.
Ching-Chun Ho et al.
Objectives: Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer. Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), as well as pr...
Stable Disease Achieved with Sequential Immunochemotherapy and Anti-Angiogenic TKI in Recurrent Metastatic Hidradenocarcinoma: A Case Report and Literature Review [0.03%]
复发性转移性汗腺癌序贯免疫化疗和抗血管生成TKI治疗后疾病稳定一例及相关文献复习
Shidi Wen,Lu Wang,Ying Jiang et al.
Shidi Wen et al.
Background: Hidradenocarcinoma is a rare and highly aggressive malignancy with limited therapeutic options. This report describes the clinical course and treatment response of a patient with recurrent metastatic hidradenocarcinoma treated w...
Cancer Drug Development in Never-Smoker Lung Cancer: Targeted and Immune-Based Therapeutic Strategies [0.03%]
从不吸烟的肺癌药物开发：靶向和免疫治疗策略
Cristian Cojocaru,Marcel Costuleanu,Ovidiu Rusalim Petriș et al.
Cristian Cojocaru et al.
Lung cancer in individuals who have never smoked (LCINS) represents a clinically and biologically distinct subset of non-small cell lung cancer, driven predominantly by oncogenic alterations rather than tobacco-related mutagenesis. This rev...
First-Line Treatment Strategies in IMDC Favourable-Risk Metastatic Clear Cell Renal Cell Carcinoma [0.03%]
国际转移性肾细胞癌联合会低危转移性透明细胞肾细胞癌的一线治疗策略
Alejandro Valdés,Jaime González-Montero,Carlos Rojas et al.
Alejandro Valdés et al.
Immune checkpoint inhibitors (ICIs) combined with vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have transformed the treatment landscape of advanced clear cell renal cell carcinoma (ccRCC). Current guidelines fav...
The Intratumoral Microbiota in Breast Cancer: Roles in Progression, Immunity, and Therapy [0.03%]
乳腺癌的瘤内微生物群：在发展、免疫和治疗中的作用
Zhihao Wei,Jijie Cai,Sifen Wang et al.
Zhihao Wei et al.
Breast cancer (BC) remains a leading cause of cancer-related mortality worldwide, and accumulating evidence suggests that tumor-associated microbiota may contribute to disease heterogeneity beyond host genetic and immune determinants. Advan...