Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways [0.03%]
两种新型吡唑衍生物作为抗肿瘤药物靶向微管蛋白聚合和MAPK信号通路的发现
Denisse A Gutierrez,Elisa Robles-Escajeda,Jose A Lopez-Saenz et al.
Denisse A Gutierrez et al.
Objectives: Drug resistance is the major determinant of chemotherapy failure, leading to relapse and tumor progression, demonstrating the urgent need for novel antineoplastic drugs. This study aimed to evaluate the antica...
miR-100-5p Enhances Cell Cycle-Mediated Chemoresistance by Modulating the CTDSPL/pRB/E2F1 Signaling Pathway in Oxaliplatin-Resistant Colorectal Cancer Cells [0.03%]
microRNA-100-5p通过调节CTDSP1/RB/E2F1信号通路增强细胞周期介导的奥沙利铂耐药结直肠癌细胞的化疗耐药性
Yen-Pin Chen,Rathinasamy Baskaran,Hema Sri Devi et al.
Yen-Pin Chen et al.
Objective: MicroRNAs (miRNAs) are small, non-coding RNAs that play a key role in the development of chemoresistance in various cancer types, including colorectal cancer (CRC). In this study, we aimed to study the underlyi...
Lorlatinib and Amivantamab: A Paradigm Shift in EGFR and ALK Positive NSCLC, with More Effective but More Toxic Treatments Requiring a Well-Structured Shared Decision Making [0.03%]
新一代肺癌靶向药物 Lorlatinib 和 Amivantamab：更有效的治疗，但毒性更高，需要结构化的共同决策模式来应对挑战
Paolo Maione,Valentina Palma,Cesare Gridelli
Paolo Maione
After about 20 years of exciting improvements in treatment efficacy outcomes of advanced epidermal growth factor receptor (EGFR) mutant and anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer (NSCLC), also combined with a...
Cholecystokinin A Receptor Knockdown Diminishes Colon Cancer Cell Invasive Potential via Modulation of Integrin/FAK, EMT, and uPA/uPAR/MMP2 Axis [0.03%]
胆囊收缩素A受体敲低通过整联蛋白/FAK、EMT和uPA / uPAR / MMP2轴的调节来降低结肠癌细胞侵袭潜能
Chun-Shiang Lin,Ta-Wen Hsu,Hsiang-Lin Lee et al.
Chun-Shiang Lin et al.
Objectives: Cholecystokinin A receptor (CCKAR) has been linked to poor prognosis in colon cancer patients, but the role of CCKAR in colon cancer cell invasiveness and the underlying mechanisms remain elusive. This study a...
Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer [0.03%]
肺癌代谢重编程及免疫调控机制研究进展
Xiaomeng Li,Xuejiao Li,Hongbo Wu et al.
Xiaomeng Li et al.
Lung cancer remains the leading cause of cancer-related mortality worldwide, primarily driven by metabolic reprogramming and immune evasion mechanisms within tumor cells. To adapt to the nutrient-deprived tumor microenvironment (TME), lung ...
Retraction: TRAF4 Regulates Migration, Invasion, and Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Hepatocellular Carcinoma [0.03%]
撤回：TRAF4通过PI3K/AKT信号转导调节肝细胞癌中的迁移、侵袭和上皮间质转化
Oncology Research Editorial Office
Oncology Research Editorial Office
[This retracts the article DOI: 10.3727/096504017X14876227286564.]. © 2026 The Author. Published by Tech Science Press.
Disulfidptosis: A Metabolic Cell Death Mechanism with Therapeutic Potential in Cancer [0.03%]
二硫化点态作用：癌症治疗中的代谢性细胞死亡机制
Wubin Zhao,Qi Wang,Jun Zhang
Wubin Zhao
Disulfidptosis is a newly identified form of regulated cell death (RCD) first described in 2023, representing a significant advance in understanding programmed cell death pathways. This unique cell death modality is characterized by abnorma...
Pre-Treatment BOC Expression as an Indicator of Lymphovascular Invasion and In Vitro Chemotherapeutic Response in Upper Tract Urothelial Carcinoma [0.03%]
上尿路尿路上皮癌中术前BOC表达作为淋巴管侵犯的标志和体外化疗反应的情况
Yin-Lun Chang,Hao-Lun Luo,Jei-Ming Peng et al.
Yin-Lun Chang et al.
Background: Upper tract urothelial carcinoma (UTUC) is an aggressive malignancy with high recurrence rates. Lymphovascular invasion (LVI) predicts a poor prognosis, yet its molecular drivers remain unclear. BOC cell adhes...
Serum Biomarkers in Bladder Cancer: NMR Metabolomics for Identification and Monitoring during Platinum-Based Therapy [0.03%]
基于铂化疗的膀胱癌的血清生物标志物：核磁共振代谢组学在鉴定和监测中的应用
Roberta Giorgione,Daniela Grasso,Elisabetta Gambale et al.
Roberta Giorgione et al.
Objectives: To date, predictive and prognostic biomarkers for Bladder Cancer (BC) remain lacking. Existing literature underscores the potential of metabolomics as a valuable tool for biomarker identification. The primary ...
Understanding the Tumor Microenvironmental Mechanisms Driving Immunotherapy Resistance in Colorectal Cancer Liver Metastases [0.03%]
colorectal cancer肝转移免疫治疗耐药的肿瘤微环境机制研究
Candela Cives-Losada,Cristiana Soldani,Michela Anna Polidoro et al.
Candela Cives-Losada et al.
Colorectal cancer (CRC) is the second deadliest cancer worldwide, being the presence of metastasis, mainly in the liver, a major contributor to high mortality rates in affected patients. The tumor microenvironment (TME)-comprised of interac...