Quantification of the neuropathology of alcohol use disorder using tissue microarrays [0.03%]
组织微阵列技术在酒精使用障碍脑部损伤量化研究中的应用
Jie Liu,Matthew J Catanzariti,Huang-Tuong Nguyen-Hao et al.
Jie Liu et al.
Alcohol use disorder (AUD) is characterized by an inability to stop consuming alcohol. Neuroimaging studies of patients with AUD show mild grey and white matter atrophy, while pathological studies suggest that atrophy is restricted to the w...
Longitudinal neuropathologic and molecular characterization of a retroperitoneal ependymoma [0.03%]
长神经病学和分子特征的腰旁室管膜瘤纵向病理表征
Emily Ling-Lin Pai,Matthew N Nazarian,Alicia L Kenyon et al.
Emily Ling-Lin Pai et al.
A novel hypertensive rat model of cerebral small vessel disease: Pathological, cognitive, and neuroimaging implications [0.03%]
一种新的小血管病高血压大鼠模型的病理、认知和神经影像学意义
Yuan Cao,Yunchao Wang,Hanghang Zhu et al.
Yuan Cao et al.
Cerebral small vessel disease (CSVD) is a major cause of stroke and dementia yet its mechanisms remain poorly understood due to the lack of reliable animal models. This study aimed to develop a novel rat model that replicates human CSVD pat...
Intratumoral heterogeneity of MYC status and methylation subtyping in group 3 medulloblastoma: A case report [0.03%]
第三组髓母细胞瘤中MYC状态和甲基化亚型的肿瘤内异质性：病例报告
Kohei Fukuoka,Tomoya Irikura,Yonehiro Kanemura et al.
Kohei Fukuoka et al.
A case series of calcium pyrophosphate deposition in the spine: An underrecognized debilitating disease [0.03%]
脊柱焦磷酸钙沉积症的病例系列分析：一种被忽视的致残性疾病
Serica J Hallstead,Jennifer M Dailey,Michael Punsoni
Serica J Hallstead
Calcium pyrophosphate deposition (CPPD) disease is an inflammatory arthritis prevalent in elderly individuals. Spinal CPPD is uncommon, and presentation can vary widely with common clinical and radiographic mimics. We identified 9 cases of ...
Identification of diagnostic biomarkers for relapsing-remitting multiple sclerosis in plasma by mass spectrometry-based proteomics [0.03%]
基于质谱的蛋白质组学鉴定血浆中诊断反复缓解型多发性硬化症的生物标志物
Víctor M García-Silva,Eduardo Chicano-Galvez,María Isabel García-Sánchez et al.
Víctor M García-Silva et al.
In the absence of molecular biomarkers, the current diagnosis of multiple sclerosis is based on clinical assessment, neuroimaging, and detection of oligoclonal bands in cerebrospinal fluid. Early and rapid diagnosis using patient samples ob...
Deposition of aggregated cystatin C-amyloid-β complexes and reduced cathepsin B activity modulate cerebral amyloid angiopathy pathogenesis [0.03%]
聚集型半胱氨酸蛋白酶抑制剂C-β淀粉样蛋白复合物的沉积和猫配体B活性降低调节脑淀粉样血管病的发生发展
Jubo Bhuiya,Abu Zaffar Shibly,Abdullah Md Sheikh et al.
Jubo Bhuiya et al.
Cystatin C (CST3) colocalizes with amyloid-β (Aβ) around vessels in cerebral amyloid angiopathy (CAA). This study aimed to characterize CST3-Aβ interactions in CAA. Brain tissues from 12 Alzheimer disease (AD) and 5 non-AD control subjec...
Brainstem tumors with subependymoma-like morphology and H3K27M mutation are epigenetically distinct [0.03%]
具有类似室管膜下瘤形态和H3K27M突变的脑干肿瘤在表观遗传上具有独特性
Junjie Yang,Zejun Duan,Jing Feng et al.
Junjie Yang et al.
The association between virus-induced spinal cord pathology and the genetic background of the host [0.03%]
病毒诱发的脊髓病变与宿主遗传背景的关系探究
Koedi S Lawley,Tae Wook Kang,Raquel R Rech et al.
Koedi S Lawley et al.
Theiler's murine encephalomyelitis virus (TMEV) infection in mice has been used to study diverse neurological diseases, including multiple sclerosis and epilepsy. In this investigation, 5 strains of collaborative cross (CC) mice were infect...
Phosphorylated tau aggregation in the brains of aged Artiodactyla animals [0.03%]
蹄纲动物脑中磷酸化tau聚集现象及其与年龄的关系研究
Yutaro Nakayama,James K Chambers,Kazuyuki Uchida
Yutaro Nakayama
The aggregation of amyloid-β (Aβ) and phosphorylated tau (p-tau) in the human brain is associated with Alzheimer disease (AD). Although Aβ aggregation has been reported in various mammals, significant p-tau aggregation has been reported ...