Drug-induced autophagic myopathies: Exploring pathophysiology with immunolabelling and proteomics [0.03%]
药物诱导的自噬性肌病：使用免疫染色和蛋白质组学探索病理生理机制
Beatrice Labella,Sarah Leonard-Louis,Emmanuelle Lacene et al.
Beatrice Labella et al.
Hydroxychloroquine (HCQ), chloroquine (CQ), and colchicine are widely used to treat autoimmune and inflammatory diseases but can cause toxic autophagic vacuolar myopathies. This study investigates the pathological mechanisms of HCQ/CQ- and ...
Neural stem cell-derived small extracellular vesicles ameliorate disease progression in the SOD1 G93A murine model of amyotrophic lateral sclerosis [0.03%]
神经干细胞来源的小细胞外囊泡改善SOD1G93A运动神经元疾病小鼠模型的病情进展
Yalan Wan,Chao Gao,Jieyu Li et al.
Yalan Wan et al.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that primarily affects motor neurons leading to muscle weakness, paralysis, and ultimately, respiratory failure. Extracellular vesicles (EVs) facilitate intercel...
Mitochondrial alterations in pellagra-associated central chromatolysis: Comparison with ballooned achromatic neurons of other etiologies [0.03%]
烟酸缺乏引起的中央嗜染质溶解的线粒体异常与其它病因引起的肿胀无色神经元的比较
Araki Kimura,Ito Kawakami,Kenji Ikeda et al.
Araki Kimura et al.
Neuronal central chromatolysis (CC) is the histopathological hallmark of pellagra encephalopathy, a neurological deficit resulting from vitamin deficiencies. Pellagrous CC neurons are morphologically similar to ballooned achromatic neurons ...
A phosphorylation‑independent monoclonal antibody improves detection of TDP‑43 pathology across frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and limbic predominant age related TDP‑43 encephalopathy neuropathological change [0.03%]
一种磷酸化非依赖性的单克隆抗体可改善TDP-43病理在额颞叶变性、肌萎缩侧索硬化和以 limbic 为主的年龄相关TDP-43脑病的神经病理学改变中的检测
Xiaojing Zheng,Ning Zhang,Lixia Wang et al.
Xiaojing Zheng et al.
TDP-43 proteinopathies encompass frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), amyotrophic lateral sclerosis (ALS-TDP), and limbic predominant age related TDP-43 encephalopathy neuropathological change (LATE-NC). These...
MN1 rearrangement detected by FISH analysis in a neuroepithelial tumor with EWSR1::PATZ1 demonstrating ependymoma-like and astroblastoma-like histology: A diagnostic pitfall [0.03%]
FISH分析检测到MN1重排的神经上皮肿瘤的ewsrsaapatz1融合，具有星形细胞瘤样和室管膜瘤样组织学：一个诊断陷阱
Takahiro Shirakura,Hajime Yonezawa,Yasuhito Arai et al.
Takahiro Shirakura et al.
Keratan sulfate proteoglycan is not expressed in human fetal cerebellar system except pontine nuclei and transitory vermal septa or in fasciculi caudal to the internal capsule [0.03%]
透明质硫酸糖蛋白不表达于人胎小脑系统除外脑桥核及暂时性小叶隔或内囊下方的投射纤维中
Harvey B Sarnat,Weiming Yu,Laura Flores-Sarnat
Harvey B Sarnat
We determined spatial/temporal expression of keratan sulfate proteoglycan (KS) in the developing cerebellar system, fasciculi, and dysgeneses. KS is an extracellular molecule secreted by astrocytes that forms a template for neuroblastic mig...
Large amyloid plaques associate with early behavioral alterations in 6-month-old APPswe/PS1dE9 mice [0.03%]
大型淀粉样斑块与APPswe/PS1dE9小鼠在6月龄时的行为改变相关联
Kseniia Sitdikova,Andrey Tsoy,Kirill D Chaprov et al.
Kseniia Sitdikova et al.
Understanding the earliest pathological changes in Alzheimer disease (AD) is critical for improving early intervention strategies. However, the relationship between amyloid plaque characteristics and early behavioral and molecular alteratio...
Clinical, genetic, and neuropathologic correlates of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC): A systematic review and meta-analysis [0.03%]
临床、遗传和神经病理学与以 limbic-predominant 年龄相关TDP-43脑病为主的神经病理变化(LATE-NC)的关系：系统评价和meta分析
Jacob Thompson,Paula K Johnson
Jacob Thompson
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) has emerged as a major contributor to cognitive decline in older adults; however, the constellation of factors associated with its presence remains poorly...
Skin biopsy for detection of phosphorylated alpha-synuclein by indirect immunofluorescence: Diagnostic accuracy in a cohort of patients with cognitive impairment [0.03%]
皮肤活检通过间接免疫荧光检测磷酸化α-突触核蛋白在认知障碍患者队列中的诊断准确性
Alessandro Furia,Alex Incensi,Cecilia Delprete et al.
Alessandro Furia et al.
Techniques for detection of dementia with Lewy bodies (DLB) are rapidly increasing. Among these are indirect immunofluorescence (IF) for identification of phosphorylated α-synuclein (p-syn) in skin tissue and real time-quaking-induced conv...
YAP1::MAML2 fusion-positive high-grade neuroepithelial tumors with rhabdoid morphology and inflammatory microenvironment: Implications for integrated diagnosis [0.03%]
YAP1-MAML2融合阳性高级别神经上皮肿瘤伴横纹肌样形态和炎性微环境：综合诊断的启示
Hainan Li,Xuemin Wei,Tiantian Han et al.
Hainan Li et al.
YAP1 fusions are well documented in pediatric central nervous system (CNS) tumors, particularly in supratentorial ependymomas and meningiomas where they are generally associated with a favorable prognosis. Outside these entities, YAP1 fusio...