An open-source application for automated quantification of Ki-67 proliferative index in meningiomas [0.03%]
一种自动计算脑膜瘤中Ki-67增殖指数的开源软件
Aaishah R Raquib,Steven N Schwartz,Shan H Siddiqi et al.
Aaishah R Raquib et al.
Ki-67 is a proliferative biomarker used for diagnosis, grading, and prognosis of various cancer types. This involves manually counting up to 1000 cells, a laborious and error-prone process due to interobserver variability. We developed and ...
Heike Kölbel,Andreas Hentschel,Corinna Preuße et al.
Heike Kölbel et al.
Biallelic pathogenic variants in SORD (Sorbitoldehydrongenase gene), encoding sorbitol dehydrogenase, are a common cause of autosomal recessive axonal Charcot-Marie-Tooth disease type 2 (CMT2). Recent evidence suggests direct involvement of...
Mechanisms contributing to the age at onset of temporal lobe epilepsy due to hippocampal sclerosis [0.03%]
导致海马硬化颞叶癫痫发病年龄的机制
Shivayogi Durgad Shwetha,Dhanya Dechamma,Praseeda Mol et al.
Shivayogi Durgad Shwetha et al.
Temporal lobe epilepsy (TLE) secondary to hippocampal sclerosis (HS) is a common cause of drug-resistant epilepsy. HS is characterized by neuronal loss in selected hippocampal subfields and gliosis. Age at epilepsy onset (AEO) critically in...
Clarification needed regarding the use of R162 as a "GluD1/GRID1 inhibitor" in a recent JNEN article on CBLN1-GRID1/GluD1 signaling in postherpetic neuralgia [0.03%]
关于最近JNEN上关于CBLN1-GRID1/GluD1信号在带状疱疹后神经痛中的作用的文章中将R162用作"GluD1/GRID1抑制剂"的用法需要澄清
Kishore Kumar S Narasimhan
Kishore Kumar S Narasimhan
Drug-induced autophagic myopathies: Exploring pathophysiology with immunolabelling and proteomics [0.03%]
药物诱导的自噬性肌病：使用免疫染色和蛋白质组学探索病理生理机制
Beatrice Labella,Sarah Leonard-Louis,Emmanuelle Lacene et al.
Beatrice Labella et al.
Hydroxychloroquine (HCQ), chloroquine (CQ), and colchicine are widely used to treat autoimmune and inflammatory diseases but can cause toxic autophagic vacuolar myopathies. This study investigates the pathological mechanisms of HCQ/CQ- and ...
Neural stem cell-derived small extracellular vesicles ameliorate disease progression in the SOD1 G93A murine model of amyotrophic lateral sclerosis [0.03%]
神经干细胞来源的小细胞外囊泡改善SOD1G93A运动神经元疾病小鼠模型的病情进展
Yalan Wan,Chao Gao,Jieyu Li et al.
Yalan Wan et al.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that primarily affects motor neurons leading to muscle weakness, paralysis, and ultimately, respiratory failure. Extracellular vesicles (EVs) facilitate intercel...
Mitochondrial alterations in pellagra-associated central chromatolysis: Comparison with ballooned achromatic neurons of other etiologies [0.03%]
烟酸缺乏引起的中央嗜染质溶解的线粒体异常与其它病因引起的肿胀无色神经元的比较
Araki Kimura,Ito Kawakami,Kenji Ikeda et al.
Araki Kimura et al.
Neuronal central chromatolysis (CC) is the histopathological hallmark of pellagra encephalopathy, a neurological deficit resulting from vitamin deficiencies. Pellagrous CC neurons are morphologically similar to ballooned achromatic neurons ...
A phosphorylation‑independent monoclonal antibody improves detection of TDP‑43 pathology across frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and limbic predominant age related TDP‑43 encephalopathy neuropathological change [0.03%]
一种磷酸化非依赖性的单克隆抗体可改善TDP-43病理在额颞叶变性、肌萎缩侧索硬化和以 limbic 为主的年龄相关TDP-43脑病的神经病理学改变中的检测
Xiaojing Zheng,Ning Zhang,Lixia Wang et al.
Xiaojing Zheng et al.
TDP-43 proteinopathies encompass frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), amyotrophic lateral sclerosis (ALS-TDP), and limbic predominant age related TDP-43 encephalopathy neuropathological change (LATE-NC). These...
MN1 rearrangement detected by FISH analysis in a neuroepithelial tumor with EWSR1::PATZ1 demonstrating ependymoma-like and astroblastoma-like histology: A diagnostic pitfall [0.03%]
FISH分析检测到MN1重排的神经上皮肿瘤的ewsrsaapatz1融合，具有星形细胞瘤样和室管膜瘤样组织学：一个诊断陷阱
Takahiro Shirakura,Hajime Yonezawa,Yasuhito Arai et al.
Takahiro Shirakura et al.
Keratan sulfate proteoglycan is not expressed in human fetal cerebellar system except pontine nuclei and transitory vermal septa or in fasciculi caudal to the internal capsule [0.03%]
透明质硫酸糖蛋白不表达于人胎小脑系统除外脑桥核及暂时性小叶隔或内囊下方的投射纤维中
Harvey B Sarnat,Weiming Yu,Laura Flores-Sarnat
Harvey B Sarnat
We determined spatial/temporal expression of keratan sulfate proteoglycan (KS) in the developing cerebellar system, fasciculi, and dysgeneses. KS is an extracellular molecule secreted by astrocytes that forms a template for neuroblastic mig...