Keratan sulfate proteoglycan is not expressed in human fetal cerebellar system except pontine nuclei and transitory vermal septa or in fasciculi caudal to the internal capsule [0.03%]
透明质硫酸糖蛋白不表达于人胎小脑系统除外脑桥核及暂时性小叶隔或内囊下方的投射纤维中
Harvey B Sarnat,Weiming Yu,Laura Flores-Sarnat
Harvey B Sarnat
We determined spatial/temporal expression of keratan sulfate proteoglycan (KS) in the developing cerebellar system, fasciculi, and dysgeneses. KS is an extracellular molecule secreted by astrocytes that forms a template for neuroblastic mig...
Large amyloid plaques associate with early behavioral alterations in 6-month-old APPswe/PS1dE9 mice [0.03%]
大型淀粉样斑块与APPswe/PS1dE9小鼠在6月龄时的行为改变相关联
Kseniia Sitdikova,Andrey Tsoy,Kirill D Chaprov et al.
Kseniia Sitdikova et al.
Understanding the earliest pathological changes in Alzheimer disease (AD) is critical for improving early intervention strategies. However, the relationship between amyloid plaque characteristics and early behavioral and molecular alteratio...
Clinical, genetic, and neuropathologic correlates of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC): A systematic review and meta-analysis [0.03%]
临床、遗传和神经病理学与以 limbic-predominant 年龄相关TDP-43脑病为主的神经病理变化(LATE-NC)的关系：系统评价和meta分析
Jacob Thompson,Paula K Johnson
Jacob Thompson
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) has emerged as a major contributor to cognitive decline in older adults; however, the constellation of factors associated with its presence remains poorly...
Skin biopsy for detection of phosphorylated alpha-synuclein by indirect immunofluorescence: Diagnostic accuracy in a cohort of patients with cognitive impairment [0.03%]
皮肤活检通过间接免疫荧光检测磷酸化α-突触核蛋白在认知障碍患者队列中的诊断准确性
Alessandro Furia,Alex Incensi,Cecilia Delprete et al.
Alessandro Furia et al.
Techniques for detection of dementia with Lewy bodies (DLB) are rapidly increasing. Among these are indirect immunofluorescence (IF) for identification of phosphorylated α-synuclein (p-syn) in skin tissue and real time-quaking-induced conv...
YAP1::MAML2 fusion-positive high-grade neuroepithelial tumors with rhabdoid morphology and inflammatory microenvironment: Implications for integrated diagnosis [0.03%]
YAP1-MAML2融合阳性高级别神经上皮肿瘤伴横纹肌样形态和炎性微环境：综合诊断的启示
Hainan Li,Xuemin Wei,Tiantian Han et al.
Hainan Li et al.
YAP1 fusions are well documented in pediatric central nervous system (CNS) tumors, particularly in supratentorial ependymomas and meningiomas where they are generally associated with a favorable prognosis. Outside these entities, YAP1 fusio...
Somatic PIK3CA and PTEN mutations with endothelial PI3K/AKT/mTOR activation in RAS-negative brain arteriovenous malformations [0.03%]
PIK3CA和PTEN体细胞突变以及内皮细胞中的PI3K/AKT/mTOR活化在RAS阴性脑动静脉畸形中的作用
Yukiko Hata,Ryo Tanaka,Shojiro Ichimata et al.
Yukiko Hata et al.
Somatic mutations affecting endothelial signaling pathways have emerged as important contributors to brain arteriovenous malformations (bAVMs). Although activating mutations in the RAS/MAPK pathway have been frequently reported, alternative...
+7/-10 chromosome copy-number alteration in the elderly: A cautionary tale from 2 cases [0.03%]
老年患者中出现的+7/-10染色体拷贝数改变：来自两例患者的警示故事
Ege Cubuk,Kenneth Aldape,Martha Quezado et al.
Ege Cubuk et al.
Mechanism of TRIM32 regulation of synaptic protein expression in the development of epilepsy in a rat model [0.03%]
TRIM32调节突触蛋白表达在癫痫大鼠模型发病机制中的作用研究
Ming Chen,Jing Pei
Ming Chen
Accumulating evidence indicates that tripartite motif-containing protein 32 (TRIM32) has important functions in brain physiology and disease. This study investigated the role of TRIM32 in the development of epilepsy and its impact on synapt...
Knockdown of TRIM21 inhibits ferroptosis via the p62-Keap1-Nrf2 pathway thereby improving brain injury and mitochondrial dysfunction after ischemia-reperfusion in mice [0.03%]
TRIM21敲低通过p62-Keap1-Nrf2信号通路抑制铁死亡从而改善小鼠缺血再灌注后脑损伤及线粒体功能障碍
Bo Yang,Yanxia Sun,Yao Zhang et al.
Bo Yang et al.
Ferroptosis has a crucial role in cerebral ischemia-reperfusion injury (IRI) but its potential modulation is a key challenge in the treatment of ischemic stroke. The function and mechanism of the E3 ubiquitin ligase tripartite motif-contain...
NICO Myriad Automated Preservation System improves meningioma sample quality for molecular pathology assays [0.03%]
NICO Myriad自动化保存系统改善了分子病理检测中的脑膜瘤样本质量
Glaucia Maria de Mendonça Fernandes,Kyle C Wu,Joshua Palmer et al.
Glaucia Maria de Mendonça Fernandes et al.
Meningiomas are central nervous system tumors primarily treated by surgery and/or radiation with large variance in progression-free survival. Emerging molecular diagnostics such as circular RNA (circRNA) profiling show potential for enhanci...