Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection [0.03%]
单细胞分析揭示宿主S期驱动BK多瘤病毒感染期间大T抗原的表达
Jason M Needham,Sarah E Perritt,Sunnie R Thompson
Jason M Needham
BK polyomavirus (BKPyV) is a major cause of kidney transplant failure, for which there are no antivirals. The current model is that BKPyV expresses TAg (large T antigen) early during infection, promoting cells to enter S phase where the vir...
The gut microbiota-independent virulence of noninvasive bacterial pathogen Citrobacter rodentium [0.03%]
无肠菌定植小鼠中的非侵袭性肠道病原细菌Citrobacter rodentium的致病性
Yue Liu,Dongqing Xu,Songwei Guo et al.
Yue Liu et al.
Attaching and effacing (A/E) bacterial pathogens consist of human pathogens enteropathogenic Escherichia coli, enterohemorrhagic E. coli and their murine equivalent Citrobacter rodentium (CR). Emerging evidence suggests that the complex pat...
Cellular sialoglycans are differentially required for endosomal and cell-surface entry of SARS-CoV-2 in lung cell lines [0.03%]
细胞唾液酸糖类以不同方式参与肺部细胞系中SARS-CoV-2的内体和细胞表面进入路径
Kimberley C Siwak,Emmanuelle V LeBlanc,Heidi M Scott et al.
Kimberley C Siwak et al.
Cell entry of severe acute respiratory coronavirus-2 (SARS-CoV-2) and other CoVs can occur via two distinct routes. Following receptor binding by the spike glycoprotein, membrane fusion can be triggered by spike cleavage either at the cell ...
Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein [0.03%]
靶向N-十四酰基转移酶通过降解Z矩阵蛋白促进泛哺乳动物雷尼病毒抑制作用
Xavier Carnec,Virginie Borges-Cardoso,Stéphanie Reynard et al.
Xavier Carnec et al.
Several Old World and New World Mammarenavirus are responsible for hemorrhagic fever in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that encodes four proteins. All Mammarenavirus identified to date share a commo...
Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage [0.03%]
干扰素ε在睾丸中产生并保护男性生殖道免受病毒侵害、发炎和受损
Rukmali Wijayarathna,Eveline D de Geus,Rosemary Genovese et al.
Rukmali Wijayarathna et al.
The testis is a reservoir for viruses that can cause persistent infection and adversely affect male reproductive health, an observation commonly attributed to deficiencies in inducible antiviral defence mechanisms. In this study, we demonst...
Newcastle disease virus infection induces parthanatos in tumor cells via calcium waves [0.03%]
新城疫病毒感染通过钙离子波诱导肿瘤细胞发生PARP依赖的坏死型细胞死亡
Yang Qu,Siyuan Wang,Hui Jiang et al.
Yang Qu et al.
Parthanatos is distinct from caspase-dependent apoptosis in that it does not necessitate the activation of caspase cascades; Instead, it relies on the translocation of Apoptosis-inducing Factor (AIF) from the mitochondria to the nucleus, re...
Ho Him Wong,Dorian Richard Kenneth Crudgington,Lewis Siu et al.
Ho Him Wong et al.
Flaviviruses orchestrate a unique remodelling of the endoplasmic reticulum (ER) to facilitate translation and processing of their polyprotein, giving rise to virus replication compartments. While the signal recognition particle (SRP)-depend...
SARS-CoV-2 Omicron variations reveal mechanisms controlling cell entry dynamics and antibody neutralization [0.03%]
SARS-CoV-2奥密克戎变异株揭示调控细胞进入动力学和抗体中和的机制
Enya Qing,Julisa Salgado,Alexandria Wilcox et al.
Enya Qing et al.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is adapting to continuous presence in humans. Transitions to endemic infection patterns are associated with changes in the spike (S) proteins that direct virus-cell entry. These c...
Chickpea NCR13 disulfide cross-linking variants exhibit profound differences in antifungal activity and modes of action [0.03%]
抗真菌活性和作用方式的深刻差异导致鹰嘴豆NCR13二硫键连接变异体形成
James Godwin,Arnaud Thierry Djami-Tchatchou,Siva L S Velivelli et al.
James Godwin et al.
Small cysteine-rich antifungal peptides with multi-site modes of action (MoA) have potential for development as biofungicides. In particular, legumes of the inverted repeat-lacking clade express a large family of nodule-specific cysteine-ri...
Vibrio cholerae RbmB is an α-1,4-polysaccharide lyase with biofilm-disrupting activity against Vibrio polysaccharide (VPS) [0.03%]
霍乱弧菌RbmB是裂解黏液多糖(VPS)的β-1,6-多糖裂解酶
Ranjuna Weerasekera,Alexis Moreau,Xin Huang et al.
Ranjuna Weerasekera et al.
Many pathogenic bacteria form biofilms as a protective measure against environmental and host hazards. The underlying structure of the biofilm matrix consists of secreted macromolecules, often including exopolysaccharides. To escape the bio...