Targeting translation initiation yields fast-killing therapeutics against the zoonotic parasite Cryptosporidium parvum [0.03%]
针对弓形虫Cryptosporidium parvum的快速杀菌疗法——瞄准蛋白质翻译起始
Meng Li,Jigang Yin,Dongqiang Wang et al.
Meng Li et al.
Cryptosporidium parvum is a zoonotic apicomplexan that causes moderate-to-severe watery diarrhea in children, immunocompromised patients, and neonatal ruminants, yet no fully effective drug is available. We show that the parasite's eukaryot...
Splicing-dependent restriction of the HBZ gene by Tax underlies biphasic HTLV-1 infection [0.03%]
转录剪接依赖的Tax对HBZ基因的限制是HTLV-1双相感染的基础
Yi Liang,Chenyang Lyu,Shuwen Xu et al.
Yi Liang et al.
HTLV-1 is an oncovirus that encodes a transactivator Tax and a regulatory gene HBZ. HTLV-1 early or infectious replication depends on Tax; during HTLV-1 late infection, HBZ plays a crucial role in driving the proliferation of infected cells...
The calcineurin pathway regulates extreme thermotolerance, cell membrane and wall integrity, antifungal resistance, and virulence in Candida auris [0.03%]
钙调磷酸酶途径调控耳霉菌的极度耐热性、细胞膜和壁完整性、抗真菌抵抗性和致病性
Hyunjin Cha,Doyeon Won,Seun Kang et al.
Hyunjin Cha et al.
Candida auris, an emerging fungal pathogen characterized by its multidrug resistance and high mortality rates, poses a significant public health challenge. Despite its importance, the signaling pathways governing virulence and antifungal re...
Characterisation of guided entry of tail-anchored proteins in Magnaporthe oryzae [0.03%]
Magnaporthe oryzae尾锚定蛋白导向性进入的特征研究
Felix Abah,Qiaojia Zheng,Xinru Chen et al.
Felix Abah et al.
Rice (Oryza sativa L.) is one of the most important staple foods for human population worldwide. However, rice production continues to be severely threatened by rice blast disease caused by an ascomycete fungus Magnaporthe oryzae. Tail-anch...
Heterogeneous impacts for malaria control from larviciding across villages and considerations for monitoring and evaluation [0.03%]
基于村庄的异质性影响的疟疾控制措施及监测与评估的思考
Ellie Sherrard-Smith,Ulrike Fillinger,Jean-Philippe B Tia et al.
Ellie Sherrard-Smith et al.
Malaria vector control tools currently focus on insecticide treated nets (ITNs) and indoor residual spraying in malaria-endemic locations, but additional preventative strategies are needed to address protection gaps. Larval source managemen...
Recent thymic emigrants preferentially undergo memory inflation after persistent infection [0.03%]
持续性感染后近期从胸腺迁移出的T细胞优先发生记忆膨胀现象
Zachary T Hilt,Arnold Reynaldi,Megan Steinhilber et al.
Zachary T Hilt et al.
Cytomegalovirus (CMV) leads to a unique phenomenon known as 'memory inflation,' where antigen-specific memory CD8 + T cells continue to accumulate in the peripheral tissues during the latent stage of infection. However, it is still not clea...
Breanna Walsh,Robert L Summers,Gabriel W Rangel et al.
Breanna Walsh et al.
Malaria remains a pressing global health challenge, with rising drug resistance threatening current treatment strategies. Partial resistance to dihydroartemisinin-piperaquine (DHA-PPQ) has emerged in Southeast Asia, particularly in Plasmodi...
Lactylation and viral infections: A novel link between metabolic reprogramming and immune regulation [0.03%]
乳酰化与病毒感染：代谢重编程与免疫调控之间的新联系
Shanshan Chen,Tongxue Qin,Shengrui Luo et al.
Shanshan Chen et al.
Post-translational modifications (PTMs) regulate protein structure, function, and interactions, playing pivotal roles in cellular processes and disease progression. Lactate, a byproduct of the Warburg effect, accumulates excessively during ...
BBK32 attenuates antibody-dependent complement-mediated killing of infectious Borreliella burgdorferi isolates [0.03%]
BBK32减弱了针对感染性伯氏疏螺旋体分离株的抗体依赖性补体介导的杀伤作用
Alexandra D Powell-Pierce,Charles E Booth,Payton G Smith et al.
Alexandra D Powell-Pierce et al.
Borreliella burgdorferi, the causative agent of Lyme disease, has evolved unique complement evasion proteins that promote its ability to establish and maintain infection in mammalian hosts. Among these is B. burgdorferi BBK32, a multifuncti...
Identification of the human cytomegalovirus gHgLgO trimer as the central player in virion infectivity [0.03%]
鉴定人类巨细胞病毒gHgLgO三聚体是病毒颗粒感染性的核心因子
Lena Thiessen,Roberto Garuti,Lucie Kubic et al.
Lena Thiessen et al.
Glycoproteins in the viral envelope of human cytomegalovirus (HCMV) orchestrate virion tethering, receptor recognition and fusion with cellular membranes. The glycoprotein gB acts as fusion protein. The gHgL complexes gHgLgO and gHgLpUL(128...