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Splicing-dependent restriction of the HBZ gene by Tax underlies biphasic HTLV-1 infection

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HTLV-1 is an oncovirus that encodes a transactivator Tax and a regulatory gene HBZ. HTLV-1 early or infectious replication depends on Tax; during HTLV-1 late infection, HBZ plays a crucial role in driving the proliferation of infected cells and maintaining vir... ...