Implications for methenamine hippurate use in recurrent urinary tract infection management: Formaldehyde resistance and altered urinary composition [0.03%]
Niamh C Hodgkinson,Tabarak Al-Rubaye,Thomas C P Reed et al.
Niamh C Hodgkinson et al.
Methenamine is a urinary antiseptic used to prevent urinary tract infections (UTI) via conversion to formaldehyde in the urinary tract. Methenamine hippurate (MH) is non-inferior compared to antibiotic (ABX) prophylaxis to manage recurrent ...
Ruth Herrmann,Michaela Herz,Kilian Rudolf et al.
Ruth Herrmann et al.
Alveolar echinococcosis (AE) is a lethal zoonosis caused by infiltrative growth of the metacestode larva of the tapeworm Echinococcus multilocularis in host organs. We previously showed that the Echinococcus metacestode is an evolutionarily...
Single-cell profiling of HDAC inhibitor-induced EBV lytic heterogeneity defines abortive and refractory states in B lymphoblasts [0.03%]
Lauren E Haynes,Ashley P Barry,Micah A Luftig
Lauren E Haynes
Epstein-Barr virus (EBV) is associated with multiple malignancies including Burkitt lymphoma (BL), Hodgkin's lymphomas, nasopharyngeal carcinomas (NPC), and gastric cancers. Canonically, EBV positive tumors display latent gene expression pr...
AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen design [0.03%]
Jelle M Melchers,Jarek Juraszek,Ruben J G Hulswit et al.
Jelle M Melchers et al.
The continued threat of zoonotic coronavirus spillovers underscores the need for cross-species applicable vaccine design strategies. The genus Embecovirus includes human coronaviruses OC43 and HKU1 as well as relevant veterinary pathogens. ...
Drosophila host defense mechanisms against filamentous fungal pathogens with diverse lifestyles [0.03%]
Guiqing Liu,Yao Tian,Mark Austin Hanson et al.
Guiqing Liu et al.
Entomopathogenic fungi serve as powerful regulators of insect populations in nature. However, how immune effectors combat fungal pathogens remains incompletely understood. We employ Drosophila melanogaster as a genetically tractable model t...
Conor W Templeton,Jasmine S Gulik,Laimonis A Laimins
Conor W Templeton
APOBECs are cytidine deaminases whose levels are increased in cells with high-risk HPV genomes and are responsible for most mutations in HPV associated cancers. APOBEC3B is a nuclear member of this family and is shown to be a positive regul...
Host response to bacteria induces a shift towards the enteroendocrine cell lineage in the murine enteroid model [0.03%]
Marry Nissan,Adrienne Ranger,Justin J Meade et al.
Marry Nissan et al.
The host response to commensal and pathogenic bacteria has been extensively characterized using human cancer cell line models but remains less defined in primary intestinal cellular systems. Recent evidence has demonstrated that mice lackin...
Tania Bernabé,María Verd,Guillem Ramis et al.
Tania Bernabé et al.
Pseudomonas aeruginosa is an opportunistic pathogen that frequently causes severe bloodstream and respiratory infections, yet the interactions between this bacterium and the innate immune system remain poorly investigated. In this study we ...
Clara Blancfuney,Eva Guchen,Marie Garcia et al.
Clara Blancfuney et al.
Helminth infections in grazing ruminants are of major concern for animal welfare and cause substantial economic losses, prompting the widespread use of ivermectin (IVM). The emergence of IVM resistance, driven by complex and poorly understo...
Microsporidian Encephalitozoon hellem inhibits host mitophagy by inducing ERAD to degrade BNIP3L [0.03%]
Ziyun Zou,Yibo Hu,Zhongxia Guan et al.
Ziyun Zou et al.
Microsporidia are known intracellular pathogens that infect nearly all animals and deeply manipulate host mitochondrial homeostasis for survival. Here, we report a novel mechanism by which the human-pathogenic Encephalitozoon hellem modulat...