Antiviral and immune modulatory activities of STING agonists in a mouse model of persistent hepatitis B virus infection [0.03%]
用于持续性乙型肝炎病毒感染小鼠模型的STING激动剂的抗病毒和免疫调节作用
Ya Wang,Shuo Wu,Xingqiong Li et al.
Ya Wang et al.
Activation of antiviral immune responses against hepatitis B virus (HBV) is essential for the durable control of chronic HBV infection and the functional cure of chronic hepatitis B. As a molecular hub at the interface of innate and adaptiv...
Quantitative ethology of schistosome miracidia characterizes a conserved snail peptide that inhibits host recognition [0.03%]
定量研究椎实螺幼虫的行为学特征，发现一种保守的椎实螺多肽能够抑制寄主识别反应
Rachel V Horejsi,Chase N Nelson,Avery De Ruyter et al.
Rachel V Horejsi et al.
Over 700 million people are at risk of contracting schistosomiasis due to regular exposure to freshwater sources where infected snails, the obligate intermediate hosts of schistosomes, are endemic. Although mass drug administration of prazi...
Rare metabolic gene essentiality is a determinant of microniche adaptation in Eschherichia coli [0.03%]
稀有代谢基因必需性决定大肠杆菌微生态位适应性
Omid Ardalani,Patrick V Phaneuf,Jayanth Krishnan et al.
Omid Ardalani et al.
Rare genes in bacterial pangenomes have historically been considered non-essential, dispensable, or even costly, and largely excluded from in-depth analyses due to their perceived redundancy, high variability, and presumed neutral evolution...
Natural competence in the bacterial pathogen Xylella fastidiosa varies across genotypes and is associated with adhesins [0.03%]
木质素降解菌棒杆菌PCL1460的基因组和功能分析
Ranlin Liu,María Pilar Velasco-Amo,Luis F Arias-Giraldo et al.
Ranlin Liu et al.
Natural competence is one of the mechanisms of horizontal gene transfer, an important process that contributes to host-use evolution and other types of environmental adaptation in bacteria. Recently, the plant pathogen Xylella fastidiosa ha...
SAMD9L inhibits flavivirus translation independently of its capacity to trigger innate immune response [0.03%]
SAMD9L独立于触发先天性免疫反应的能力抑制黄病毒翻译
Marion Cannac,Jim Zoladek,Inès Bribes et al.
Marion Cannac et al.
Interferon-stimulated genes (ISGs) play a pivotal role in the innate immune response to viral infection. Among them, SAMD9 and its paralog SAMD9L have recently emerged as important antiviral effectors with translation-inhibitory activity. W...
Engineering a multivalent antibody nanoparticle to overcome SARS-CoV-2 Omicron immune evasion [0.03%]
工程化重链多价抗体纳米颗粒以应对新冠病毒奥密克戎株的免疫逃逸
Hui Sun,Yanan Jiang,Miaolin Lan et al.
Hui Sun et al.
The rapid evolution of SARS-CoV-2 and the subsequent emergence of Omicron subvariants pose significant challenges to the efficacy of existing vaccines and therapeutics, including those previously reported most broad neutralizing antibodies ...
Rooting for data: A FAIR research data management and data analysis environment for the PlantMicrobe research collaboration [0.03%]
植微生物合作研究中的FAIR原则——构建良好的科研数据管理与数据分析环境
Frederik Dröst,Ursula Eberhardt,Alexander Wellmann et al.
Frederik Dröst et al.
Heterologous expression of HCoV-HKU1 ORF 7b by mouse hepatitis virus protects against severe disease during murine infection [0.03%]
利用小鼠肝炎病毒异源表达人冠状病毒HKU1的orf7b可保护小鼠在感染过程中不患重症
Chaminda D Gunawardene,Isha Pandey,Shruti Chatterjee et al.
Chaminda D Gunawardene et al.
Coronaviruses express a repertoire of accessory proteins for evading host immune responses. A small internal (I) accessory gene overlaps with the nucleocapsid (N) gene in an alternative reading frame of viruses that belong to the genus Beta...
The recombinant zoster vaccine induces trained immunity in monocytes through persistent downregulation of TGFβ [0.03%]
重组带状疱疹疫苗通过持续下调TGFβ诱导单核细胞训练免疫
Michael J Johnson,Megan Crotteau,Debashis Ghosh et al.
Michael J Johnson et al.
Older adults have decreased vaccine efficacy, but the adjuvanted recombinant VZV-gE zoster vaccine (RZV) is highly efficacious. We investigated memory-like innate immune responses after RZV and aftrer the zoster vaccine live (ZVL), which is...
Meteorological and environmental drivers of West Nile virus prevalence in Culex pipiens mosquitoes in Emilia-Romagna, Italy in 2013 to 2022 [0.03%]
2013年至2022年意大利艾米利亚-罗马涅地区Cx. pipiens蚊虫中西尼罗河病毒流行的气象和环境驱动因素
Victoria M Cox,Katie Tiley,Roberto Rosa et al.
Victoria M Cox et al.
As West Nile Virus (WNV) is expanding its geographical range across Europe, there is an urgent need to characterise and better understand its transmission drivers to inform public health surveillance, disease control, and preparedness plann...