Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosis [0.03%]
表型可塑性增强结核分枝杆菌的药物耐受性
Abigail M Frey,Gregory H Babunovic,Peter H Culviner et al.
Abigail M Frey et al.
Antibiotic pressure causes pathogens to evolve many forms of altered drug susceptibility. In addition to target or activator mutations conferring canonical drug resistance, mutations can serve as steppingstones to or enhancers of resistance...
Glutamine supports human cytomegalovirus induced lipidome remodeling through reductive carboxylation [0.03%]
谷氨酰胺通过还原性羧化作用支持人巨细胞病毒诱导的脂质组重塑
Rebekah L Mokry,Caleb B de Lacy,John G Purdy
Rebekah L Mokry
Lipidome remodeling during human cytomegalovirus (HCMV) replication is a complex process that requires induction of lipogenic proteins and altered metabolite flow to support synthesis of fatty acids and lipids. HCMV infection increases the ...
The major diagnostic VSG LiTat 1.3 of the human parasite Trypanosoma brucei gambiense is a trimer in solution [0.03%]
人类寄生虫布氏锥虫的主诊断型VSG LiTat 1.3蛋白在溶液中以三聚体形式存在
Niki Danel,Rob Geens,Israel Mares-Mejía et al.
Niki Danel et al.
Human African trypanosomiasis (HAT) remains a significant health burden in sub-Saharan Africa, with serological diagnosis relying heavily on parasite variant surface glycoproteins (VSGs). Experimentally validated structural studies of VSGs ...
The major diagnostic VSG LiTat 1.3 of the human parasite Trypanosoma brucei gambiense is a trimer in solution [0.03%]
人类寄生虫布氏锥虫的主诊断型VSG LiTat 1.3蛋白在溶液中以三聚体形式存在
Niki Danel,Rob Geens,Israel Mares-Mejía et al.
Niki Danel et al.
Human African trypanosomiasis (HAT) remains a significant health burden in sub-Saharan Africa, with serological diagnosis relying heavily on parasite variant surface glycoproteins (VSGs). Experimentally validated structural studies of VSGs ...
Marie Thirion,Alice J Stelfox,Florian Chenavier et al.
Marie Thirion et al.
Influenza viruses belong to the Orthomyxoviridae family, they are categorized into four types: A, B, C, and D. Influenza B viruses co-circulate annually with influenza A strains during seasonal flu epidemics in humans, causing severe diseas...
Rationally designed minimized TbpB confers broad protection against meningococcal infection [0.03%]
合理设计的最小化TbpB对脑膜炎奈瑟菌感染具有广谱保护作用
Epshita A Islam,Jamie E Fegan,Gregory B Cole et al.
Epshita A Islam et al.
Transferrin binding protein B (TbpB), an iron acquisition protein, has long been recognized as a promising vaccine candidate targeting the pathogenic Neisseria species, including Neisseria meningitidis, the cause of meningococcal disease, a...
Rab9 depletion enhances human adenovirus type 26 transduction efficiency through increased internalization and reduced late endosomal/lysosomal retention [0.03%]
Rab9缺失通过增加内吞和减少晚期内体/溶酶体滞留来增强人腺病毒26型转导效率
Isabela Drašković,Davor Nestić,Lucija Lulić Horvat et al.
Isabela Drašković et al.
Understanding intracellular trafficking is central to decoding viral pathogenesis and engineering optimized viral vectors. How a virus or vector is routed through the endocytic pathway directly dictates its genome release, immune sensing, a...
Perturbing H-NS function reveals roles in restricting virulence heterogeneity and pathogen adaptation [0.03%]
扰动H-NS功能揭示其限制毒力异质性和病原体适应性的作用
Leah McLelland,Madison Spratt,Dakshya Karki et al.
Leah McLelland et al.
Xenogeneic silencers, such as histone-like nucleoid structuring protein (H-NS), are critical for maintaining horizontally acquired genes in bacterial genomes and minimizing fitness costs associated with inappropriate expression. For bacteri...
Directed evolution of a stem-helix-targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity [0.03%]
针对茎部螺旋的抗体的定向进化通过增强亲和力实现对MERS-CoV的交叉中和作用
Panpan Zhou,Meng Yuan,Yuexiu Zhang et al.
Panpan Zhou et al.
Broadly neutralizing antibodies (bnAbs) targeting conserved regions of the betacoronavirus spike are important for pan-betacoronavirus protection and pandemic preparedness. Here, we report the isolation of a human monoclonal antibody, CC65....
Proteasome-dependent cytoskeleton disruption during Leptospira interrogans infection induces aberrant collective cell migration [0.03%]
钩端螺旋体感染通过泛素蛋白酶体系统依赖性地破坏细胞骨架引起上皮细胞集体迁移异常
Hunter Barbee,Isabel Sebastián,Romina Tokumon et al.
Hunter Barbee et al.
Leptospira interrogans is a causative agent of leptospirosis, a potentially life-threatening zoonotic disease. A major symptom of severe leptospirosis is acute kidney failure; this is characterized by the detachment of renal proximal tubule...