Secreted LysM proteins are required for niche competition and full virulence in Pseudomonas savastanoi during host plant infection [0.03%]
分泌的LysM蛋白是Pseudomonas savastanoi在感染宿主植物期间争夺生态位和发挥全部致病性所必需的
Hilario Domínguez-Cerván,Laura Barrientos-Moreno,Luis Díaz-Martínez et al.
Hilario Domínguez-Cerván et al.
Phytopathogenic bacteria secrete diverse virulence factors to manipulate host defenses and establish infection. Characterization of the type III secretion system (T3SS)- and HrpL-independent secretome (T3-IS) in Pseudomonas savastanoi pv. s...
You can go your own way: The targeting signals of trypanosomatid parasites [0.03%]
你有你的路：贾第虫类寄生虫的目标信号分子
Max Pendlebury,Julius Lukeš,Michael J Hammond
Max Pendlebury
Structural and functional studies of rabbit SAMD9 reveal a distinct tRNase module that underlies the antiviral activity [0.03%]
结构与功能研究揭示兔SAMD9具有独特的tRNase模块并介导其抗病毒活性
Juhi Chaturvedi,Fushun Zhang,Chen Zhang et al.
Juhi Chaturvedi et al.
Human SAMD9 and SAMD9L (collectively SAMD9/9L) are large cytoplasmic proteins with antiviral and antiproliferative activities, recently shown to regulate protein synthesis by specifically depleting phenylalanine tRNA (tRNAPhe). The enzymati...
Two mutations in NS2B are responsible for attenuation of the yellow fever virus (YFV) vaccine strain 17D [0.03%]
NS2B中的两个突变导致黄热病毒(YFV)活疫苗株17D的弱化
Xueer Qiu,Adam L Bailey
Xueer Qiu
Vaccines have done more to improve the health of humankind over the past century than almost any other technology. Among vaccines, the live-attenuated yellow fever (YF) vaccine (17D) is highly effective, providing long-lasting immunity agai...
A non-classical PUF family protein in oomycetes functions as a pre-rRNA processing regulator and a target for RNAi-based disease control [0.03%]
卵菌中一类非经典PUF家族蛋白质作为前rRNA加工调节因子及基于RNAi的病害防治靶点
Hui Feng,Tianli Liu,Chuanxu Wan et al.
Hui Feng et al.
Ribosome biogenesis is an essential and tightly regulated process linked to cell proliferation and growth. However, its regulatory mechanisms in oomycetes, a group of organisms with significant agricultural and ecological importance, remain...
Rémy Gerard,Antoine Dewitte,Fridolin Gross et al.
Rémy Gerard et al.
Sepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ dysfunction and high mortality. Despite advances in treatment, sepsis remains difficult to manage. Historically, the concept of s...
Convergent mechanisms of epithelial cell structure manipulation by intestinal pathogens [0.03%]
肠道病原体操纵上皮细胞结构的汇合机制
Elena Rodrigues,N Bishara Marzook,Mitchell A Pallett et al.
Elena Rodrigues et al.
The epithelial layer that lines the digestive system serves as the primary barrier to infection by intestinal pathogens. While this layer has evolved complex molecular mechanisms to identify and respond to infection, pathogens have also evo...
Two receptor-targeting mechanisms of lambda-like siphophage Gifsy-1 of Salmonella Typhimurium [0.03%]
沙门氏菌Gifsy-1噬菌体两种受体靶向机制
Xiaoli Zeng,Wenyu Wang,Dekang Zhu et al.
Xiaoli Zeng et al.
The receptor-targeting mechanisms by which λ-like siphophages establish infection in gram-negative bacteria remain poorly characterized. This study demonstrated that the λ-like phage Gifsy-1, which exhibits broad lytic activity in Salmone...
VapC toxins promote the pathogenesis of Rickettsia heilongjiangensis by cleaving essential RNAs from both Rickettsia and its host [0.03%]
沙粒病毒VapC毒素通过切割立克次氏体及其宿主的必要RNA促进赫蒙立克次体致病性
Yan Liu,Weiting Zhou,Jiaying Zhao et al.
Yan Liu et al.
Toxin-antitoxin (TA) modules enable bacteria to persist under stressful environments. However, they are typically absent from host-associated prokaryotes due to their potential host toxicity. Here, the obligate intracellular bacterium spott...
Over-expression and increased copy numbers of a cytochrome P450 and two UDP-glucuronosyltransferase genes in macrocyclic lactone resistant Psoroptes ovis of cattle [0.03%]
牛恶癖螨大环内酯类抗生素抗性相关细胞色素P450和两个尿苷二磷酸葡萄糖醛酸转移酶基因的过表达及拷贝数增加
Jack Hearn,Wouter van Mol,Roel Meyermans et al.
Jack Hearn et al.
Psoroptes ovis is a mite species that feeds on sheep, cattle, other ungulates, rabbits, and horses, which can develop into a severe exudative dermatitis known as psoroptic mange. The macrocyclic lactone (ML) family of acaricides are commonl...