TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages [0.03%]
肿瘤坏死因子α通过促进巨噬细胞产生CXCL1来加重SARS-CoV-2感染
Moe Kobayashi,Nene Kobayashi,Kyoka Deguchi et al.
Moe Kobayashi et al.
Since most genetically modified mice are C57BL/6 background, a mouse-adapted SARS-CoV-2 that causes lethal infection in young C57BL/6 mice is useful for studying innate immune protection against SARS-CoV-2 infection. Here, we established tw...
Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness [0.03%]
SARS-CoV-2中出现的新型突变有利于逃逸NK细胞识别并可能增强病毒适应度
Eleni Bilev,Nicole Wild,Pouria Momayyezi et al.
Eleni Bilev et al.
In addition to adaptive immunity, natural killer (NK) cells of the innate immune system contribute to the control of viral infections. The HLA-E-restricted SARS-CoV-2 Nsp13232-240 epitope VMPLSAPTL renders infected cells susceptible to NK c...
A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo [0.03%]
一种有效且具有高度选择性的疟原虫专一性酪氨酰-tRNA合成酶反应劫持抑制剂，可实现单剂量口服治疗效果
Stanley C Xie,Chia-Wei Tai,Craig J Morton et al.
Stanley C Xie et al.
The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase (PfTyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates. We previously identified an exemplar pyrazolopyrimidine ...
Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep [0.03%]
羊乳中传播人畜共患的Wesselsbron病毒（无需蚊虫叮咬）
Marta Zimoch,Llorenç Grau-Roma,Matthias Liniger et al.
Marta Zimoch et al.
Wesselsbron virus (WSLV) is a zoonotic, mosquito-borne orthoflavivirus endemic to sub-Saharan Africa, causing abortions and stillbirths in small ruminants. The life cycle of WSLV involves Aedes mosquitoes and various wildlife and domestic a...
H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication [0.03%]
H5亚型禽流感病毒通过TFE3通路诱导高尔基体应激以促进病毒复制
Yuncong Yin,Xianjin Kan,Xinyu Miao et al.
Yuncong Yin et al.
During infection, avian influenza virus (AIV) triggers endoplasmic reticulum (ER) stress, a well-established phenomenon in previous research. The Golgi apparatus, situated downstream of the ER and crucial for protein trafficking, may be imp...
Skin as outermost immune organ of vertebrates that elicits robust early immune responses after immunization with glycoprotein of spring viraemia of carp virus [0.03%]
鲤春病毒血症病毒糖蛋白诱导的脊椎动物外周免疫器官产生早期高效免疫应答研究
Zhao Zhao,Liang Zhao,Xue-Feng Wei et al.
Zhao Zhao et al.
As the outermost immune organ in vertebrates, the skin serves as the primary interface with the external environment and plays a crucial role in initiating the early immune response. The skin contains a variety of immune cells that induce m...
SUMO-targeted Ubiquitin Ligases as crucial mediators of protein homeostasis in Candida glabrata [0.03%]
SUMO靶向泛素连接酶作为蛋白质稳态在光滑假丝酵母中的关键介质
Dipika Gupta,Renu Shukla,Krishnaveni Mishra
Dipika Gupta
Candida glabrata is an opportunistic human pathogen, capable of causing severe systemic infections that are often resistant to standard antifungal treatments. To understand the importance of protein SUMOylation in the physiology and pathoge...
A-synuclein prion strains differentially adapt after passage in mice [0.03%]
人α-突触核蛋白病理性聚集体在小鼠中传代后的不同适应性变异
Sara A M Holec,Chase R Khedmatgozar,Shelbe J Schure et al.
Sara A M Holec et al.
In patients with synucleinopathies, the protein α-synuclein misfolds into multiple conformations, each of which determines whether a patient develops multiple system atrophy (MSA) or one of three Lewy body diseases (LBDs). However, patient...
Receptor binding and structural basis of raccoon dog ACE2 binding to SARS-CoV-2 prototype and its variants [0.03%]
刺突蛋白受体结合域与食蟹獴ACE2复合物的结构及新冠病毒原型株及其变异株与其食蟹獴ACE2的结合研究
Chunliang Luo,Linjie Li,Yuhang Gu et al.
Chunliang Luo et al.
Raccoon dog was proposed as a potential host of SARS-CoV-2, but no evidence support such a notion. In our study, we investigated the binding affinities of raccoon dog ACE2 (rdACE2) to the spike (S) protein receptor binding domain (RBD) of S...
Insights into the structural changes that trigger receptor binding upon proteolytic activation of Bacillus thuringiensis Vip3Aa insecticidal protein [0.03%]
巴氏芽胞杆菌Vip3Aa杀虫蛋白丝氨酸蛋白酶激活后受体结合的结构变化机制解析
Oscar Infante,Isabel Gómez,Angel E Pélaez-Aguilar et al.
Oscar Infante et al.
Bacillus thuringiensis (Bt) bacteria produce different pore forming toxins with insecticidal activity, including Cry and Vip3 proteins. While both Cry and Vip3 cause insect death by forming pores in susceptible lepidopteran larval midgut ce...