CD24-Fc resolves inflammation and enhances anti-HIV CD8 T cells with polyfunctionality during HIV-1 infection under ART [0.03%]
CD24-Fc可在抗逆转录病毒治疗期间缓解HIV-1感染引发的炎症并增强具有多重功能的抗HIV CD8T细胞
Guangming Li,Jianping Ma,Haisheng Yu et al.
Guangming Li et al.
The persistence of HIV-1 reservoirs during combination anti-retroviral therapy (cART) is associated with chronic inflammation and systemic immune activation in people infected with HIV-1 (PWH), leading to a suboptimal immune reconstitution ...
Host-induced climate change: Carbon dioxide tolerance as a Cryptococcus neoformans virulence trait [0.03%]
由宿主引起的气候变化：二氧化碳耐受性是新型隐球菌致病性的一种特征
Emma E Blackburn,Laura C Ristow,Xiaorong Lin et al.
Emma E Blackburn et al.
E2F1 suppresses Epstein-Barr virus lytic reactivation through cellular and viral transcriptional networks [0.03%]
E2F1通过细胞和病毒转录网络抑制EB病毒潜伏感染的激活反应
Joyanta Biswas,Sk Asif Ali,Samaresh Malik et al.
Joyanta Biswas et al.
Epstein-Barr virus (EBV) establishes life-long persistence infection displaying a biphasic viral life cycle - latent phase and lytic replication. While latent EBV infection is linked to several B- and epithelial cell malignancies, periodic ...
Comparison of HIV-1 A6 dispersal dynamics in Poland before and after the war in Ukraine [0.03%]
乌克兰战争前后的波兰A6型HIV-1传播动态比较
Karol Serwin,Kaja Mielczak,Anna Urbańska et al.
Karol Serwin et al.
The war-related migrations from Ukraine to Poland have resulted in an increased prevalence of individuals diagnosed with human immunodeficiency virus type 1 (HIV-1) A6 variant. We examined the impact of the influx of people living with HIV ...
A novel combination therapy with Uridine and Praziquantel effectively alleviates schistosomiasis-induced hepatic fibrosis through promoting adipogenic differentiation [0.03%]
尿苷与吡喹酮联合治疗有效缓解肝纤维化通过促进脂肪分化作用机制研究新的组合疗法
Xiangyu Zhou,Qingkai Xue,Chengwei Wu et al.
Xiangyu Zhou et al.
Schistosomiasis-induced hepatic fibrosis, a consequence of egg-induced granulomatous lesions, remains untreated by current drugs. Therefore, the development of novel antifibrosis drugs is of paramount importance. Our previous study indicate...
Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity [0.03%]
抗体分型的模式及母胎冠状病毒特异性体液免疫转移的功能后果
Andrew P Hederman,Hannah M Brookes,Harini Natarajan et al.
Andrew P Hederman et al.
Maternal antibodies serve as a temporary form of inherited immunity, providing humoral protection to vulnerable neonates. Whereas IgG is actively transferred up a concentration gradient via the neonatal Fc Receptor (FcRn), maternal IgA and ...
HBV capsid assembly modulators differentially modulate the assembly of wild-type and drug-resistant core protein chimeric nucleocapsids and empty capsids [0.03%]
HBV衣壳装配调节剂可差异调控野生型和药物耐受型核心蛋白嵌合核酸内体及空壳的聚合装配
Hui Liu,Hemraj Rimal,Jun Lyu et al.
Hui Liu et al.
Multiple capsid assembly modulators (CAMs) are in clinical development for the treatment of chronic hepatitis B. The emergence of CAM-resistant HBV has resulted in the failure of CAM antiviral therapy in recent clinical trials. Because wild...
Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions [0.03%]
肺炎链球菌通过程序性DNA倒位同步化细胞壁肽聚糖乙酰化和基因组甲基化的状态
Xiu-Yuan Li,Ping He,Shaomeng Wang et al.
Xiu-Yuan Li et al.
Bacterial cell wall peptidoglycan (PG) consists of alternating β-(1,4) linked N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG). The C-6 hydroxyl group of NAM is acetylated by transmembrane O-acetyltransferases post PG biosynthesis ...
Plants, fungi, and antifungals: A little less talk, a little more action [0.03%]
植物、真菌和抗真菌药：少一点空谈，多一点行动
George Ly,James M Bradley,Dario Bonetta et al.
George Ly et al.
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells [0.03%]
由Uukuniemi病毒引起的感染会重塑蜱细胞中的RNA结合蛋白组
Alexandra Wilson,Wael Kamel,Kelsey Davies et al.
Alexandra Wilson et al.
Cellular RNA-binding proteins (RBPs) are pivotal for the viral lifecycle, mediating key host-virus interactions that promote or repress virus infection. While these interactions have been largely studied in the vertebrate host, no comprehen...