Inflammasome activation dictates the efficacy of antimycobacterial activity of frontline TB drugs [0.03%]
细胞内抗菌作用一线抗结核药物的疗效由炎症小体活化决定
Anjali Singh,Kanika Bisht,Garima Maurya et al.
Anjali Singh et al.
Recent developments in tuberculosis (TB) treatment have identified an enormous potential of host-directed therapies (HDT)) in achieving better and faster control of infection. We have previously demonstrated the synergistic effect of sertra...
Salmonella effector kinase SteC is activated by phosphorylation at Serine 379 [0.03%]
司命素效应物激酶SteC通过丝氨酸379磷酸化被激活
Timesh D Pillay,Briac Lemetais,Jessica Huber et al.
Timesh D Pillay et al.
The pathogen Salmonella, which causes significant human morbidity and mortality, encodes an effector kinase, SteC, which mediates actin polymerisation and cell migration. Given the minimal nature of its kinase domain, it remains unclear how...
The antiviral GTPase MxB is packaged into virions and binds via its N-terminal domain to alphaherpesvirus capsids [0.03%]
抗病毒GTP酶MxB包装到病毒体并经其N端结构域与α疱疹病毒衣壳结合
Sebastian Weigang,Manutea C Serrero,Boris Bogdanow et al.
Sebastian Weigang et al.
The interferon-inducible myxovirus resistance proteins (Mx) belong to the dynamin-like GTPases; MxA is a restriction factor against several RNA viruses, while MxB restricts infections of lentiviruses and herpesviruses. Humans express MxA(1-...
Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 is dependent on presentation of VP4 peptide immunogens in a virus-like conformation [0.03%]
中和抗体的诱导依赖于以病毒样构象呈现的VP4表位肽免疫原来针对冠状病毒保守的衣壳蛋白VP4
James T Kelly,Giann Kerwin Y Dellosa,Joseph Newman et al.
James T Kelly et al.
Infection with rhinovirus (RV) is a frequent cause of the common cold and is also associated with more significant morbidity, including hospitalisation, in people with chronic lung disease. At present, there is no licensed RV vaccine or ant...
The Sigma1 ER membrane receptor promotes structural protein folding and genome packaging of dengue virus [0.03%]
Sigma1内质网膜受体促进登革病毒结构蛋白折叠和基因组包装
Riya Sarkar,Whitney Reid,Renaldo Sutanto et al.
Riya Sarkar et al.
Dengue virus (DENV) exploits the host endoplasmic reticulum (ER) to support viral protein translation and folding, replication, and assembly, although the identity of ER factors that promote these distinct steps during infection remain uncl...
A novel penicillin-binding protein inhibitor with unprecedented intracellular activity eradicates multiple pathogenic bacteria [0.03%]
一种新型青霉素结合蛋白抑制剂具有前所未有的胞内活性可清除多种病原菌
Kai-Xuan Guo,Hong-Xia Hu,Zhen Cheng et al.
Kai-Xuan Guo et al.
The escalating crisis of antibiotics against Gram negative bacteria resistance demands innovative strategies to combat recalcitrant intracellular pathogens. We reposition RS 17053, an α1A-adrenoceptor antagonist with unexplored antibacteri...
Genome-wide CRISPR screen reveals PEX11B as a host restriction factor against ORFV through membrane fluidity regulation [0.03%]
利用膜流动性调控筛选出PEX11B作为ORFV的宿主限制因子
Xiaoran Gao,Jinyang Hao,Sha Lu et al.
Xiaoran Gao et al.
Host-pathogen interactions are shaped by cellular restriction factors that direct antiviral defenses. We built the first ovine genome-wide CRISPR knockout library in sheep testis (OA3.Ts) cells, targeting all protein-coding genes. Using thi...
Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axis [0.03%]
呼吸病毒通过干扰素信号转导子和激活蛋白1/5b-细胞因子信号传导抑制蛋白1轴激活自噬
Victoria Hunszinger,Susanne Klute,Zoé Engels et al.
Victoria Hunszinger et al.
Autophagy is an ancient catabolic process that has emerged as part of innate immunity. Upon infection, autophagy is activated but the key factors responsible remained unclear. Here, we show that interferon (IFN) released during viral infect...
Dynamic tethering of M protein drives pathological inflammation during group A Streptococcus infections [0.03%]
链球菌感染期间M蛋白动态拴系引发病理炎症反应
Ananya Dash,Stephanie Guerra,Doris L LaRock et al.
Ananya Dash et al.
The M protein of Group A Streptococcus (GAS) is an essential virulence factor that promotes both superficial and invasive infections, as well as the development of immune sequela, including acute rheumatic fever and rheumatic heart disease....
Longitudinal analysis of high-risk HPV infections reveals within-host viral genome changes over time [0.03%]
纵向分析高危人乳头瘤病毒的感染可揭示病毒基因组随时间的变化
Sambit K Mishra,Meredith Yeager,Chase W Nelson et al.
Sambit K Mishra et al.
Persistent infection with high-risk (HR)-HPV causes cervical cancer, however, it is unclear why most infections resolve while a minority progress. We deep sequenced the HPV genomes of 1,228 HR-HPV-positive serial samples from 351 women with...