High-fidelity long-read sequencing of an avian herpesvirus reveals extensive intrapopulation diversity in tandem repeat regions [0.03%]
高保真长读序文禽疱疹病毒揭示串联重复区域内的广泛种群内多样性
Alejandro Ortigas-Vasquez,Christopher D Bowen,Daniel W Renner et al.
Alejandro Ortigas-Vasquez et al.
Comparative genomic studies of Marek's disease virus (MDV) have suggested that attenuated and virulent strains share >98% sequence identity. However, these estimates fail to account for variation in regions of the MDV genome harboring tande...
The Egh16-like virulence factor TrsA of the nematode-trapping fungus Arthrobotrys flagrans facilitates intrusion into its host Caenorhabditis elegans [0.03%]
棘孢黏帚霉中的Egh16同源毒力因子TrsA可促进其侵入宿主秀丽隐杆线虫肠道
Jennifer Emser,Lena Seidler,Elma Kovačević et al.
Jennifer Emser et al.
The first physical barrier pathogenic microbes need to overcome for host colonization is the cuticle, epidermis, or skin of an animal. The nematode-trapping fungus Arthrobotrys flagrans is able to catch and digest nematodes like Caenorhabdi...
The use of X-ray computed tomography for advanced detection of Globodera pallida [0.03%]
X射线计算机断层扫描技术在检测淡紫拟盘革菌中的应用研究
Eric C Pereira,Christopher A Bell,Peter E Urwin et al.
Eric C Pereira et al.
Potato cyst nematodes (PCN), namely Globodera pallida, pose a significant threat to potato production worldwide. Accurately quantifying nematode population densities is crucial for effective management strategies. However, traditional detec...
Human tonsil organoids reveal innate pathways modulating humoral and cellular responses to ChAdOx1 [0.03%]
人扁桃体类器官揭示了调节对ChAdOx1的体液和细胞反应的先天途径
Maria Fransiska Pudjohartono,Kate Powell,Eleanor Barnes et al.
Maria Fransiska Pudjohartono et al.
The COVID-19 pandemic response demonstrated the effectiveness of adenovirus vector vaccines in inducing protective cellular and antibody responses. However, we still lack mechanistic understanding of the factors regulating immunity induced ...
Emerging challenges for mosquito-borne disease control and the promise of symbiont-based transmission-blocking strategies [0.03%]
蚊媒疾病防控面临的新挑战及共生体干扰传病策略的前景展望
Han Gao,Wenqian Hu,Chunlai Cui et al.
Han Gao et al.
Mosquitoes serve as vectors for a variety of pathogens that cause life-threatening diseases, such as malaria, dengue, Zika, and yellow fever. With the rise of antimalarial drug resistance and a lack of therapeutics or prophylactics for deng...
Stenotrophomonas maltophilia complex: A broadly distributed emerging pathogen [0.03%]
马尔罗尼单胞菌复合体：一种广泛分布的新兴病原体
Cristian V Crisan,Joanna B Goldberg
Cristian V Crisan
DCLK1 isoform (DCLK1-S) as a critical player in promoting inflammation, tissue remodeling, and EMT in mouse models of colitis [0.03%]
DCLK1剪接异构体DCLK1-S在结肠炎小鼠模型中促进炎症、组织重塑和上皮间质转化的作用研究
Kafayat Yusuf,Badal C Roy,William L Hauser et al.
Kafayat Yusuf et al.
Background and aims: The Doublecortin-like kinase-1 (DCLK1) plays a chemosensory role in the gut. It's role in the context of inflammatory diseases including inflammatory bowel disease (IBD), has not been thoroughly inves...
Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection [0.03%]
单价和多价Mpox蛋白纳米颗粒疫苗可对正痘病毒感染产生交叉保护作用
Lijun Zhang,Chuanyu Liu,Chenxi Yang et al.
Lijun Zhang et al.
The outbreak of mpox since 2022 has driven the development of mpox virus (MPXV)-specific, subunit-based, next-generation vaccines, instead of the currently used live-attenuated vaccinia virus (VACV) vaccines. Here, we describe a self-assemb...
Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription [0.03%]
Daxx介导的组蛋白H3.3在HSV-1DNA上的沉积限制了基因组去压缩和早期转录的进行
Ashley P E Roberts,Anne Orr,Victor Iliev et al.
Ashley P E Roberts et al.
Herpesviruses are ubiquitous pathogens that cause a wide range of disease. Upon nuclear entry, their genomes associate with histones and chromatin modifying enzymes that regulate the progression of viral transcription and outcome of infecti...
Abundant genetic variation is retained in many laboratory schistosome populations [0.03%]
实验小鼠中许多基因遗传多样性被保留下来
Kathrin S Jutzeler,Roy N Platt,Robbie Diaz et al.
Kathrin S Jutzeler et al.
Schistosomes are obligately sexual blood flukes that can be maintained in the laboratory using freshwater snails as intermediate and rodents as definitive hosts. The genetic composition of laboratory schistosome populations is poorly unders...