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Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection

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The outbreak of mpox since 2022 has driven the development of mpox virus (MPXV)-specific, subunit-based, next-generation vaccines, instead of the currently used live-attenuated vaccinia virus (VACV) vaccines. Here, we describe a self-assembling protein nanopar... ...