Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants [0.03%]
腺病毒突变体通过活化不同的dsRNA传感器从而组装RNP颗粒
Robert T Steinbock,Orlando B Scudero,Joseph M Dybas et al.
Robert T Steinbock et al.
Recognition of double-stranded RNA (dsRNA) triggers antiviral defense mediated by PKR and OAS3/RNase L pathways through translational arrest and RNA decay. This is accompanied by assembly of distinct cytoplasmic ribonucleoprotein (RNP) cond...
The lipid A acylation pattern of Coxiella burnetii prevents detection and clearance by the non-canonical inflammasome in primary murine macrophages [0.03%]
贝纳氏立克次体的脂质A酰基模式可防止其被小鼠原代巨噬细胞中的非经典炎症小体识别和清除
Manuela Szperlinski,Faiza Asghar,František Csicsay et al.
Manuela Szperlinski et al.
C. burnetii is a Gram-negative, obligate intracellular bacterium and the causative agent of Q fever. The disease is either asymptomatic or manifests as a mild flu-like illness, but pneumonia or hepatitis might also occur. In most cases, the...
EV-B 3D polymerase remodels viral populations through 5'UTR recombination to subvert cardiac antiviral innate immunity [0.03%]
EV-B RNA聚合酶通过IRES重组重塑病毒群体，以对抗心脏的抗病毒先天免疫反应
Marie Glenet,Laetitia Heng,Anne-Laure Lebreil et al.
Marie Glenet et al.
Viral myocarditis, a leading cause of morbidity in young populations, is strongly linked to Coxsackievirus B (CV-B) infections harboring dominant 5'-terminally deleted (5'TD) and minor full-length (FL) CV-B RNA populations in cardiac tissue...
Broad and durable protection against SARS-CoV-2 and SARS-CoV by an intranasal chimpanzee adenovirus vaccine expressing tandem RBDs and nucleocapsid [0.03%]
通过表达串联RBD和核衣壳的黑猩猩腺病毒鼻腔疫苗获得针对SARS-CoV-2和SARS-CoV的广泛而持久的保护力
Yaping Liu,Runhong Zhou,Tian Zhao et al.
Yaping Liu et al.
Current intramuscular COVID-19 vaccines reduce severe disease but offer limited protection against infection, enabling viral persistence, immune escape, and transmission. We developed intranasal rare-serotype chimpanzee adenovirus 68 (AdC68...
Repurposing screens reveal a role for PKCη and NF1 in SARS-CoV-2 infection [0.03%]
药物再利用筛选发现PKCη和NF1在SARS-CoV-2感染中的作用
Jorge A Acuña,Jesse Miller,Smita Bhutda et al.
Jorge A Acuña et al.
SARS-CoV-2 continues to circulate with the emergence of variants that evade existing immunity. However, all strains rely on conserved host factors for entry, making them attractive targets for host-directed antivirals. SARS-CoV-2 engages th...
A single DNA methylation site regulates cell fate during Clostridioides difficile sporulation [0.03%]
DNA甲基化在艰难梭菌孢子形成过程中的细胞命运决定中起作用
Pola Kuhn,John W Ribis,Mi Ni et al.
Pola Kuhn et al.
DNA methylation is a widespread phenomenon in bacteria that can regulate gene expression, although the mechanisms underlying this epigenetic regulation are often poorly understood. In Clostridioides difficile, the orphan DNA methyltransfera...
Longitudinal study of a rodent invasion reveals shifts in host pathogen interactions [0.03%]
一项啮齿动物入侵的纵向研究表明宿主病原体相互作用发生了变化
Andrew McManus,Maxime Galan,Nathalie Charbonnel et al.
Andrew McManus et al.
Invasive species can disrupt native epidemiological processes, potentially leading to the emergence of zoonotic pathogens. The relatively recent appearance and spread of the bank vole (Clethrionomys glareolus) in Ireland provides a unique m...
Environmental drivers of low vaccine responsiveness in a lab-to-wild rodent model [0.03%]
实验室到野外啮齿动物模型中疫苗反应低的环境驱动因素
Simon A Babayan,Saudamini Venkatesan,Jessica L Hall et al.
Simon A Babayan et al.
Vaccination is the most effective way to prevent infectious diseases and safeguard public health. Yet, most new vaccines fail in late clinical trials, and even established ones often underperform in populations apart from those in which the...
Cdc42 and Rac2 act through the formin-like Frl/FMNL to control lamellocyte shape and encapsulation of parasitoid wasp eggs in Drosophila [0.03%]
CDC42和Rac2通过类似formin的Frl/FMNL控制果蝇浆细胞形状并包裹寄生蜂卵
Darius Molitor,Hermann Schillers,Sven Bogdan
Darius Molitor
Drosophila has been established as a powerful genetic model to study not only blood cell development but also innate cellular immunity. Lamellocytes are the most distinct blood cell type which are large key effector cells in the anti-parasi...
Quercetin, a flavonoid, suppresses viral proliferation by interfering with the ubiquitin transfer from E1 to E2 enzymes [0.03%]
黄酮类化合物檞皮素通过干扰E1-E2泛素转移抑制病毒增殖
Hanbo Li,Yu Li,Bowen Yin et al.
Hanbo Li et al.
Quercetin is recognized for diverse pharmacological activities. However, the mechanism underlying its broad-antiviral effects has not been elucidated. Herein, we identified quercetin as a potent inhibitor of both double-stranded DNA virus B...