YAP Inhibits HIV-1 transcription and promotes HIV-1 latency by regulating E3 ubiquitin ligase UHRF1 mediated tat degradation [0.03%]
YAP通过调节E3泛素连接酶UHRF1介导的tat蛋白降解抑制HIV-1转录并促进HIV-1潜伏感染
Chenliang Zhou,Hong He,Yuzai Zhang et al.
Chenliang Zhou et al.
The latency of human immunodeficiency virus type 1 (HIV-1) is a major barrier to achieving an HIV-1 cure, as antiretroviral therapy does not target the latent virus. Virus-host interactions play an essential role in various stages of the HI...
Metarhizium anisopliae: A fungal biocontrol agent against Rhipicephalus microplus [0.03%]
用于防治Rhipicephalus microplus的绿僵菌代谢产物
Júlia de Fraga Sant&#x;Ana,Lucélia Santi,Walter Orlando Beys-da-Silva
Júlia de Fraga Sant&#x;Ana
The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid [0.03%]
宿主蛋白环磷酸肽酶A通过降低HIV-1突变体衣壳的弹性来限制其进入细胞核
Jun Hong,Akshay Deshpande,Yatish Thakare et al.
Jun Hong et al.
Binding of the host protein cyclophilin A (CypA) to the viral capsid exerts multiple effects on HIV-1 infection, including enhancement of reverse transcription, stabilization of the capsid, and promotion of nuclear entry. CypA can also inhi...
The effect of combining HIV latency reversal with inhibition of phosphoinositide-3 kinases or B-cell lymphoma-2 on the HIV reservoir [0.03%]
联合运用HIV潜伏逆转与磷脂酰肌醇3-激酶或B细胞淋巴瘤抑制对HIV储存库的影响
Youry Kim,Jenny L Anderson,Carolin Tumpach et al.
Youry Kim et al.
The persistence of latently infected CD4 + T-cells in people with HIV (PWH) on suppressive antiretroviral therapy (ART) is the major barrier to an HIV cure. We investigated the impact of two classes of pro-apoptotic drugs, phosphoinositide-...
Examining the role of IgA in a persistent model of Staphylococcus aureus colonization [0.03%]
IgA在金黄色葡萄球菌持续定植模型中作用的研究
Yunys Perez-Betancourt,Miaomiao Shi,Dominique Missiakas
Yunys Perez-Betancourt
Staphylococcus aureus is a human-adapted pathogen that replicates by asymptomatically colonizing its host. Nasal colonization occurs in the first weeks of life and persists in about 30% of the population. Using the mouse-adapted strain WU1 ...
A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion [0.03%]
内膜复合体内的一种类似纺锤体的转运蛋白对隐孢子虫细胞分裂、运动和侵染至关重要
Syrian G Sanchez,Romuald Haase,David J Dubois et al.
Syrian G Sanchez et al.
The Major Facilitator Superfamily (MFS) comprises a large and diverse group of membrane transport proteins involved in the translocation of metabolites across cellular membranes. The genome of Toxoplasma gondii encodes approximately 60 puta...
Jean R P Gatdula,Robert C C Mercer,Jose Andres Alepuz Guillen et al.
Jean R P Gatdula et al.
The mechanism by which prions composed of PrPSc cause the neuropathological aberrations characteristic of prion diseases remains elusive. Previous studies have defined a synaptotoxic signaling pathway in which extracellular PrPSc stimulates...
Frankie M T Lyons,Jill Chmielewski,Mikha Gabriela et al.
Frankie M T Lyons et al.
Malaria parasite fertilisation occurs within the Anopheles mosquito midgut. Interventions that inhibit parasite fertilisation prevent ongoing transmission and are important for malaria elimination efforts. Pfs48/45 and Pfs230 are two leadin...
White spot syndrome virus IE1 protein hijacks the host pentose phosphate pathway to fuel viral replication [0.03%]
白斑综合征病毒IE1蛋白劫持宿主戊糖磷酸途径以促进病毒复制
Jia Zhang,Kaiyu Lu,Jinghua Zhu et al.
Jia Zhang et al.
Viruses frequently reprogram host metabolism to support their replication. The pentose phosphate pathway (PPP), a key regulator of nucleotide synthesis and redox balance, is often targeted during infection. While PPP activation is well-know...
Tissue-resident macrophage and dendritic cells drive type I IFN immunity to enteroviruses in the liver [0.03%]
肝内的组织驻留巨噬细胞和树突状细胞驱动I型IFN抗肠道病毒免疫响应
Emma Heckenberg,Jacob G Davis,Caitlin Hale et al.
Emma Heckenberg et al.
Enteroviruses are major causes of neonatal morbidity and mortality, with echovirus infections commonly associated with severe disease, including acute liver failure. The human neonatal Fc receptor (hFcRn) is the primary receptor for echovir...