Mechanistic insights into CAM-induced disruption of HBV capsids revealed by all-atom MD simulations [0.03%]
通过全原子MD模拟揭示CAM诱导破坏HBV衣壳的机制见解
Carolina Pérez-Segura,Boon Chong Goh,Jodi A Hadden-Perilla
Carolina Pérez-Segura
Capsid assembly modulators (CAMs) represent a promising antiviral strategy against hepatitis B virus (HBV), but their effects on pre-formed capsids remain incompletely understood. Here, all-atom molecular dynamics (MD) simulations of intact...
Legionella effector protein SidG disrupts host cytoskeleton via targeting Arp2/3 complex [0.03%]
利什曼热沙门菌效应蛋白SidG通过作用于Arp2/3复合体干扰细胞骨架重组
Jiayang Liu,Siyao Liu,Rundong Shu et al.
Jiayang Liu et al.
Legionella pneumophila is a facultative intracellular bacterial pathogen capable of surviving and replicating within host cells, including macrophages and protozoans. It employs the Dot/Icm type IV secretion system (T4SS) to inject over 330...
Plasmodium falciparum stomatin-like protein forms a putative complex with a metalloprotease in distinct mitochondrial loci [0.03%]
恶性疟原虫血红素聚合酶与金属蛋白酶在特化线粒体定位中形成假定复合体
Julie M J Verhoef,Ezra T Bekkering,Cas Boshoven et al.
Julie M J Verhoef et al.
Members of the Stomatin, Prohibitin, Flotillin and HflK/C (SPFH) protein family form large membrane anchored or spanning complexes and are involved in various functions in different organelles. The human malaria causing parasite Plasmodium ...
Differential roles of the type I and II secretion systems for the intracellular ABC141 Acinetobacter baumannii infection, which elicits an atypical hypoxia response in endothelial cells [0.03%]
I型和II型分泌系统在ABC141不动杆菌胞内感染中的不同作用及其诱导血管内皮细胞异常缺氧反应的作用
Charline Debruyne,Landon Hodge,Karsten Hokamp et al.
Charline Debruyne et al.
Acinetobacter baumannii poses a substantial global health threat, causing severe multi-drug-resistant infections in hospitalized patients. Circulating clinical isolates present remarkable diversity, with a proportion capable of establishing...
Breaking disulfide bonds in a weakly bactericidal α-defensin unleashes a potent antimicrobial peptide with an altered conformation [0.03%]
在弱杀菌性α-防御素中断裂二硫键可释放出具有改变构象的强抗菌肽
Gan Luo,Mingzhu Zhao,Qingxia Wang et al.
Gan Luo et al.
Harnessing antimicrobial peptides as bactericidal agents affords an attractive approach to developing new anti-infective therapies. We found that abolishing disulfide bonding in mouse cryptdin 1 (Crp1), a weakly bactericidal α-defensin of ...
Cytotoxic lymphocytes counteract viral type I interferon immune evasion [0.03%]
细胞毒性淋巴细胞可对抗病毒I型干扰素免疫逃避作用
Michael Y Schakelaar,Liling Shan,Shuang Li et al.
Michael Y Schakelaar et al.
Viruses are recognized by host cell innate immunity through viral RNA/DNA sensing by cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING). However, many viruses evade cGAS-STING signaling and antiviral IFN-β response. Here...
Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines [0.03%]
西方马脑炎病毒的硫酸肝素结合位点改造及其在设计减毒活疫苗中的应用
Tetyana Lukash,Shishir Poudyal,Theron C Gilliland Jr et al.
Tetyana Lukash et al.
Encephalitogenic alphaviruses are mosquito-borne viruses that can cause fatal disease in humans and equines. Currently, there are no licensed vaccines or antiviral treatments for these infections. Western equine encephalitis virus (WEEV) is...
Regnase-1-mediated regulation of neutrophils modulates SARS-CoV-2 pneumonia [0.03%]
_REGNASE-1介导的中性粒细胞调节调控新型冠状病毒肺炎_
Keiko Yasuda,Junichi Aoki,Kotaro Tanaka et al.
Keiko Yasuda et al.
The innate immune response to viral infection needs to be tightly regulated to ensure effective pathogen clearance while avoiding excessive immune activation. During SARS-CoV-2 infection, however, the immune system often fails to elicit app...
Flexibility and modulation of translation initiation in enterovirus genomes [0.03%]
肠道病毒基因组起始密码子的灵活性和修饰性
Rhian L O&#x;Connor,Georgia M Cook,Jacqueline Hankinson et al.
Rhian L O&#x;Connor et al.
Enteroviruses comprise a large group of mammalian pathogens that often utilize two open reading frames (ORFs) to encode their proteins: the upstream protein (UP) and the main polyprotein. In some enteroviruses, in addition to the canonical ...
Neural cells are susceptible to historic and recently emerged Oropouche virus strains [0.03%]
神经细胞易感于欧罗波切病毒历史株和近期新兴毒株
Kaleigh A Connors,Maris R Pedlow,Zachary D Frey et al.
Kaleigh A Connors et al.
Oropouche fever is a re-emerging global viral threat caused by infection with Oropouche virus (OROV). While disease is generally self-limiting, historical and recent reports of neurologic involvement highlight the importance of understandin...