RSAD2/VIPERIN and CMPK2 coordinate an immunometabolic response to Epstein-Barr Virus [0.03%]
RSAD2/VIPERIN和CMPK2协调对EB病毒的免疫代谢反应
Urvi S Zankharia,Adam M Glass,Wujuan Zhang et al.
Urvi S Zankharia et al.
Epstein-Barr Virus (EBV) infection and reactivation in B-lymphocytes are tightly regulated by host antiviral response genes. In the present study, we identify Interferon Stimulated Genes (ISGs) RSAD2 (radical S-adenosyl methionine domain-co...
Structural and functional characterization of a conserved cryptic epitope on SARS-CoV-2 spike S2 subunit [0.03%]
SARS-CoV-2刺突蛋白S2亚基上一个保守的隐蔽表位的结构和功能特征分析
Ling Zhou,Ching-Lin Hsieh,Sarah R Leist et al.
Ling Zhou et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone extensive evolution since its emergence in 2019, underscoring the continuous need for vaccines and therapeutics effective against multiple variants of concern (VOCs)...
Topical formulation of repurposed FDA-approved compounds inhibits Pseudomonas aeruginosa ExoU and improves corneal infection outcomes [0.03%]
一项关于将再利用的FDA批准化合物局部配方制剂用于抑制绿脓杆菌ExoU并改善角膜感染结果的研究
Daniel M Foulkes,David G Fernig,Keri McLean et al.
Daniel M Foulkes et al.
Microbial keratitis caused by Exotoxin U (ExoU)-producing strains of Pseudomonas aeruginosa is associated with poor clinical outcomes and reduced responsiveness to antimicrobial therapy. ExoU, a phospholipase, is secreted directly into host...
Nelson Bay Orthoreovirus cell attachment protein σC determines strain-specific differences in infectivity and pathogenesis [0.03%]
Nelson Bay正黏液病毒细胞附着蛋白σC决定毒株特异性的感染性和致病性差异
Takahiro Kawagishi,Yusuke Sakai,Hiroya Oki et al.
Takahiro Kawagishi et al.
Nelson Bay orthoreovirus (NBV) was initially discovered in a bat sample but has since been isolated from patients with acute respiratory tract diseases. Accumulating reports of NBV isolation from patients with respiratory tract viral infect...
Marcus V Merfa,Tracy E Hawk,Jelmer W Poelstra et al.
Marcus V Merfa et al.
Epidemic preparedness depends on tracking microbial evolution that drives shifts in ecological behaviors such as disease emergence. However, the genetic constraints mediating microbial emergence for generalist and specialist behaviors remai...
Marcela Fuentes-Carias,Viviane Noll Louzada-Flores,Isabelle Louradour
Marcela Fuentes-Carias
The residue 86 of the Getah virus E2 glycoprotein mediates both glycosaminoglycan- and LDLR-dependent infection [0.03%]
Getah病毒E2糖蛋白残基86介导硫酸肝素和LDLR依赖性感染
Xiangshu Qiu,Rongguang Lu,Jiaxin Tian et al.
Xiangshu Qiu et al.
Getah virus (GETV), a mosquito-borne alphavirus, poses an emerging threat to public health with its increasingly broad host spectrum. While glycosaminoglycans (GAGs) serve as critical attachment factors for many alphaviruses and the low-den...
Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells [0.03%]
自然杀伤细胞颗粒蛋白(NKG7)促进疫苗诱导的抗真菌Th1细胞的发育
Marcel Wüthrich,Cleison Ledesma Taira,Lucas Dos Santos Dias et al.
Marcel Wüthrich et al.
CD4+ T cells that produce IFN-γ (T helper 1 [Th1] cells) chiefly mediate vaccine acquired resistance to fungal infections. However, the key regulators of the development of Th1 cells and acquired resistance to fungi are incompletely unders...
Zi-Qi Gu,You-Yan Chen,Yu-Huan Tsai
Zi-Qi Gu
DNA oligonucleotides block viral entry of SARS-CoV-2 Omicron variants [0.03%]
DNA寡核苷酸可阻断SARS-CoV-2奥密克戎变异株的感染入侵
Jorge A Acuña,Benjamin Gabriel,Kasirajan Ayyanathan et al.
Jorge A Acuña et al.
Successful viruses including SARS-CoV-2 antagonize and evade immune detection to establish infection. As population immunity to the ancestral strain has risen, new variants-particularly Omicron-have evolved to avoid detection by both circul...