The C5a-C5aR1 axis facilitates blood-brain barrier disruption induced by EV-A71 infection through neutrophil activation [0.03%]
C5a-C5aR1轴通过激活中性粒细胞介导肠道病毒A71感染所致血脑屏障破坏
Peiyu Zhu,Xiaofeng Zeng,Xin Yuan et al.
Peiyu Zhu et al.
Enterovirus A71 (EV-A71), a member of the genus Enterovirus within the family Picornaviridae, induces neuroinflammation; however, the underlying mechanisms remain incompletely understood. This study demonstrates that the C5a-C5aR1 axis play...
Candida albicans activates Staphylococcus aureus virulence regulatory systems to drive toxin-mediated human cell death [0.03%]
白色念珠菌激活金黄色葡萄球菌毒力调节系统以促进毒素介导的人体细胞死亡
Kara R Eichelberger,Ravishankar Chandrasekaran,Nicholas A Podar et al.
Kara R Eichelberger et al.
Co-infection with Staphylococcus aureus and Candida albicans leads to worsened disease severity compared to mono-microbial infection. Because our understanding of the mechanisms driving enhanced disease severity during co-infection is incom...
Systematic profiling of nudivirus-like genes reveals conserved and differentiated roles in a domesticated endogenous virus [0.03%]
系统性分析类纽迪病毒基因揭示了一种内源病毒中保守和差异化的功能角色
Yuenan Zhou,Kaijie Ding,Sijie Zhang et al.
Yuenan Zhou et al.
Cotesia vestalis bracovirus (CvBV) is a type of domesticated endogenous virus (DEV) derived from ancestral nudiviruses that is integrated into the genome of the parasitoid wasp Cotesia vestalis. The CvBV proviral genome is composed of two d...
Long-term depletion of KIR3DL01+ NK cells by adeno-associated viral-vectored antibody delivery alters chronic SIV infection [0.03%]
长期耗尽KIR3DL01+NK细胞并采用腺相关病毒-抗体递送法可改变慢性猴免疫缺陷病毒感染状况
Kjell Sandstrom,Grace N Hagedorn,Sean C Robinson et al.
Kjell Sandstrom et al.
Natural killer (NK) cells are key innate effectors during antiviral immune responses, with their activity regulated in part by interactions between polymorphic killer-cell immunoglobulin-like receptors (KIRs) on NK cells and their major his...
Transcriptomic timeseries links hepatic gene expression to an early and self-limited systemic response to enteric infection [0.03%]
转录组时间序列揭示肝脏基因表达与肠源性感染引起的早期且自限性的全身炎症反应之间的关联
Yuko Hasegawa,Akina Osaki,Masataka Suzuki et al.
Yuko Hasegawa et al.
The liver receives microbe and host signals from the intestine via the portal vein, thereby connecting the gut to systemic physiology. Homeostatic control of the timing of systemic responses is critical to prevent the expansion and dissemin...
The parasitophorous vacuole membrane of Toxoplasma gondii: A custom structural framing with smart interior plumbing for resource allocation [0.03%]
侵袭性寄生虫病原体托拉川巴氏虫的胞内寄生泡膜：一种带有智能内部管道系统的定制结构框架，用于资源分配
Julia D Romano,Shahbaz M Khan,Isabelle Coppens
Julia D Romano
In essence, the parasitophorous vacuole (PV) of Toxoplasma is a "Do-It-Yourself" renovation project led by the parasite after invasion of a guest house (the host cell) to install itself surreptitiously in a private and custom-built room, re...
A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model [0.03%]
一种自我补充的重组腺相关病毒载体编码无锚嗜伊红蛋白，该蛋白带有G127V突变，可延长啮齿动物朊病毒疾病模型的生存期
Thomas Zerbes,Claire Verkuyl,Cunjie Zhang et al.
Thomas Zerbes et al.
The replacement of a single codon in the human prion gene, causing the substitution of glycine with valine at position 127 (G127V) of the prion protein (PrP), prevents development of prion disease. We set out to explore if prion disease sur...
Does Toxoplasma gondii infection have a causal impact on human psychopathology? A Mendelian randomization analysis [0.03%]
弓形虫感染对人类精神疾病有无因果关系？孟德尔随机化分析研究
Jinyong Pang,Matthew J Valente,Kami Kim et al.
Jinyong Pang et al.
Toxoplasma gondii (T. gondii) is a prevalent zoonotic parasite that has been implicated in influencing human psychiatric disorders and risk-taking behaviors. Using genome-wide association study (GWAS) data, we selected 25 and 76 single-nucl...
The SARS-CoV-2 S2'-helix compared to stem-helix confers higher genetic barrier to antibody resistance [0.03%]
与茎螺旋相比，SARS-CoV-2 S2'-螺旋具有更高的遗传屏障以抵抗抗体耐药性
Xuanjia Wang,Shitong Qiao,Zhiheng Bao et al.
Xuanjia Wang et al.
Understanding the potential for resistance to antibodies targeting conserved epitopes on the coronavirus spike protein is essential for developing broad-spectrum antivirals. The S2'-helix and stem helix represent two key conserved epitopes ...
Direct interaction between RSV polymerase L and active Rab11a mediates viral ribonucleoprotein transport to assembly sites [0.03%]
RSV聚合酶L与活化Rab11a的直接相互作用介导病毒核糖核蛋白向装配位点的运输
Claire Giry,Ana Joaquina Jimenez,Julie De Oliveira et al.
Claire Giry et al.
Respiratory syncytial virus (RSV) is an enveloped, negative-sense, single-stranded RNA virus whose ribonucleoproteins (vRNPs) must be transported from cytoplasmic viral factories to the plasma membrane for efficient virion assembly. Viral v...