Structural and mechanistic insights into caseinolytic protease inhibition for antimicrobial development against Pseudomonas plecoglossicida [0.03%]
针对Pseudomonas plecoglossicida的抗微生物开发中的乳蛋白酶抑制和结构与机制见解
Jingjie Chen,Ping Zhang,Hongxin Guan et al.
Jingjie Chen et al.
The caseinolytic protease (ClpP) is an emerging antibacterial target. Pseudomonas plecoglossicida (Pp), a pathogen causing visceral white spot disease in Larimichthys crocea, encodes two ClpP paralogs, PpClpP1 and PpClpP2. This study charac...
Identification of multiple Acinetobacter baumannii protein antigens as targets for potential immunotherapies using a novel protein microarray screening approach [0.03%]
利用新型蛋白质微阵列筛查方法鉴定多个巴氏不动杆菌蛋白抗原作为潜在免疫治疗靶点
Samantha Palethorpe,Giuseppe Ercoli,Elisa Ramos-Sevillano et al.
Samantha Palethorpe et al.
The World Health Organisation has identified Acinetobacter baumannii as a critical priority antimicrobial resistant (AMR) pathogen for which new therapeutics are needed. Despite this, currently there are no antibody or vaccine candidates in...
A humanized IFN-γ mouse model reveals skin eschar formation, enhanced susceptibility and scrub typhus pathogenesis [0.03%]
人源化IFN-γ小鼠模型揭示了皮肤焦痂形成、易感性增加及丛林斑疹伤寒的发病机制
Ryan H Cho,Lihai Gao,Hui Wang et al.
Ryan H Cho et al.
Scrub typhus, caused by Orientia tsutsugamushi (Ot) bacteria, is a serious acute febrile illness associated with significant mortality. No effective vaccine is currently available, largely due to the complex Ot strain diversity and an incom...
Interferon-β induction heterogeneity during KSHV infection is correlated to levels and activation of the transcription factors ATF2 and RelA, and not IRF3 [0.03%]
ATF2和RelA而不是IRF3的水平和活化与KSHV感染过程中的干扰素-β诱导异质性相关
Machika Kaku,Marta Maria Gaglia
Machika Kaku
Careful regulation of type I interferons (IFN) like IFN-β is vital for balancing tissue damage and protection against infections. Heterogeneity in type I IFN expression among virally infected cells is a common phenomenon that may help limi...
Consequences of prion strain mixtures: Indifference, competition, or collusion [0.03%]
朊毒株混合的后果：无关、竞争或合谋
Amanda L Woerman,Jason C Bartz
Amanda L Woerman
Quantitative proteomics of infected macrophages reveals novel Leishmania virulence factors [0.03%]
感染巨噬细胞的定量蛋白质组学揭示了新的利什曼原虫毒力因子
Nicolas Hagedorn,Albert Fradera-Sola,Melina Mitnacht et al.
Nicolas Hagedorn et al.
Leishmaniasis is a major public health problem, causing diseases ranging from self-healing skin lesions to life-threatening chronic infections. Understanding how Leishmania parasites evade the host defense system is crucial for understandin...
Precision targeting: The dawn of artificially customized disease resistance [0.03%]
精准定位：人工定制疾病抵抗力的曙光
Xinyue Fan,Shanwu Lyu,Wenqian Fan et al.
Xinyue Fan et al.
Advanced plant disease management strategies are essential to sustainable agriculture and global food security. Advances in plant immunity have given rise to a variety of innovative disease control strategies, such as NLR gene transfer, RNA...
Amikacin-eravacycline combination mediates the synergistic elimination of carbapenem-resistant pathogens via in vitro and in vivo metabolic reprogramming [0.03%]
阿米卡星-依拉考星联合用药通过体内外代谢重编程协同消除碳青霉烯耐药病原菌
Xiaoli Yang,Yili Chen,Jinmei Yang et al.
Xiaoli Yang et al.
Carbapenem-resistant (CR) organisms (CRO) have been identified as critical priority pathogens, emphasizing the urgent need for novel therapeutic strategies. Combination therapy emerges as a promising approach to address multidrug-resistant ...
A SARS-CoV-2 variant-induced NTD-targeting antibody enhances viral infection via a distinctive binding mode [0.03%]
一种SARS-CoV-2变异诱发的NTD靶向抗体通过独特的结合模式增强病毒感染
Wenting Li,Congcong Liu,Yaning Li et al.
Wenting Li et al.
SARS-CoV-2 infection elicits both neutralizing and non-neutralizing monoclonal antibodies (mAbs), primarily targeting to the N-terminal domain (NTD), receptor-binding domain (RBD), and S2 subunit of the spike protein. Notably, a unique subs...
Correction: Identification of the Pseudomonas aeruginosa AgtR-CspC-RsaL pathway that controls Las quorum sensing in response to metabolic perturbation and Staphylococcus aureus [0.03%]
订正：鉴定出一种由铜绿假单胞菌AgtR-CspC-RsaL构成的通路，该通路在代谢紊乱和金黄色葡萄球菌作用下控制Las群体感应
PLOS Pathogens Staff
PLOS Pathogens Staff
[This corrects the article DOI: 10.1371/journal.ppat.1013054.]. Copyright: © 2026 The PLOS Pathogens Staff. This is an open access article distributed u...
Published Erratum
PLoS pathogens. 2026 Feb 10;22(2):e1013944. DOI:10.1371/journal.ppat.1013944 2026