Zhicheng Dou
Zhicheng Dou
A designed peptide disrupting viral protease cleavage restores cGAS-DNA phase separation and type I interferon responses [0.03%]
一种设计多肽可破坏病毒蛋白酶切割并恢复cGAS-DNA相分离及I型干扰素应答
Hongyan Yin,Zhenchao Zhao,Haiwei Wang et al.
Hongyan Yin et al.
Seneca Valley Virus (SVV) 3C protease is essential for viral polyprotein processing and virion assembly. Meanwhile, it has evolved to cleave and antagonize the multiple innate immune proteins, enabling viral immune evasion. Inhibitors of 3C...
Yad fimbriae are triggered by host cues and enhance extraintestinal pathogenic Escherichia coli tissue colonisation during bloodstream infection [0.03%]
宿主信号触发耶尔森菌丝状菌毛并在血流感染过程中增强肠外病原性大肠杆菌的组织定植作用
Chloe Ellison,Curtis Cottam,Zheng Jie Lian et al.
Chloe Ellison et al.
Bacterial pathogens that infect host sites beyond their native ecological niche must be equipped to cope with unique challenges across distinct environments. This often manifests in the upregulation of virulence factors specifically in resp...
M-Sec promotes the production of infectious HIV-1 virus through the exocyst complex in macrophages [0.03%]
M-Sec通过胞外体复合物促进巨噬细胞中具有感染性的HIV-1病毒的产生
Reem M Mahmoud,Masateru Hiyoshi,Randa A Abdelnaser et al.
Reem M Mahmoud et al.
We have demonstrated that the cellular protein M-Sec promotes the transmission of human immunodeficiency virus type 1 (HIV-1) in macrophages. However, the underlying mechanism is not fully understood. Here, we report that M-Sec promotes the...
Targeting BRD2 and BRD4 inhibit the growth of KSHV-infected immortalized endothelial cells through suppression of LANA translation [0.03%]
靶向BRD2和BRD4通过抑制LANA翻译来抑制KSHV感染的永生内皮细胞增殖
Jungang Chen,Jiaojiao Fan,Margaret Qin et al.
Jungang Chen et al.
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), both of which still lack effective treatment options. Members of the bromod...
Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity [0.03%]
尿苷胞苷激酶调控molnupiravir活化及其抗SARS-CoV-2活性
Huazhang Shu,Julian M Ludäscher,Sushma Sharma et al.
Huazhang Shu et al.
Molnupiravir is a nucleoside analogue antiviral drug against RNA viruses, including its clinical indication SARS-CoV-2. Whilst its mechanism-of-action is well defined, host factors that regulate its therapeutic responses have not been thoro...
Maternal antibody-mediated elimination of a Puumala hantavirus outbreak in a bank vole colony [0.03%]
雌性抗体介导的银行业小杆鼠布库纳病毒爆发的消除
Stephan Drewes,Julia Wyszkowska,Ewa Jaromin et al.
Stephan Drewes et al.
Bank voles (Myodes glareolus syn. Clethrionomys glareolus) are frequently used as an animal model in ecological and biomedical studies and are an important reservoir of viral and bacterial zoonotic pathogens, e.g., Puumala hantavirus (PUUV)...
Anthony Loddo,Pierre Delobel,Camille Vellas
Anthony Loddo
Homotypic interactions between SLAMF1 receptors on innate T cells and neutrophils regulate killing of fungi [0.03%]
天然T细胞和中性粒细胞之间的SLAMF1受体同型相互作用调节真菌杀伤作用
Lindsay Suarez Lau,Sarah Lichtenberger,Cleison Ledesma Taira et al.
Lindsay Suarez Lau et al.
Innate lymphocytes and myeloid cells communicate and play an essential part in activating neutrophils and other effector cells to kill fungi. Here, we identified that Signaling Lymphocytic Activation Molecule 1 (SLAMF1) orchestrates a cellu...
LuxS/AI-2 regulates phoP/phoQ by a non-canonical mechanism to enhance acid stress survival in Salmonella Typhimurium [0.03%]
LuxS/AI-2通过非canonical机制调节鼠伤寒沙门氏菌的PhoP/Q，从而增强酸胁迫耐受性
Anmol Singh,Abhilash Vijay Nair,Shashanka Aroli et al.
Anmol Singh et al.
The intestinal milieu is largely characterized by the complex array of chemical compounds produced through the metabolic activity of resident microbiota. Enteric pathogens like Salmonella, which have evolved refined mechanisms to persist wi...