The natural history and evolution of dermatophytosis: Host immunity in acute and chronic infection [0.03%]
表皮癣菌病的自然史和进化：急性感染和慢性感染中的宿主免疫反应
Aditya K Gupta,Tong Wang,Anuradha Chowdhary et al.
Aditya K Gupta et al.
Evaluating beta-tubulin variants as predictors of benzimidazole resistance across Caenorhabditis nematodes [0.03%]
评估β-微管蛋白变异体在钙头孢菌线虫苯并咪唑抗性预测中的作用
Amanda O Shaver,Ryan McKeown,Joyce M Reyes Otero et al.
Amanda O Shaver et al.
Benzimidazoles, a widely used class of anthelmintic drugs, target beta-tubulin, disrupt microtubule formation, and delay nematode development. In parasitic nematodes, mutations in beta-tubulin genes are predicted to inhibit benzimidazole bi...
HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition [0.03%]
HIV-1 BG505 SOSIP免疫诱导出针对465糖孔的B细胞增殖，产生多种构象中和抗体
August Myers,Monika Chandravanshi,Leanne S Whitmore et al.
August Myers et al.
High serum neutralization following BG505 SOSIP.664 envelope trimer immunization was associated with protection against BG505.SHIV challenge in rhesus macaques in a previous study. In an animal that developed high titer, durable neutralizat...
Feedback coordination of FoxO-mediated antibacterial immunity by PDGF/VEGF signaling establishes hemolymph microbiota homeostasis in shrimp [0.03%]
表皮生长因子和血管内皮生长因子信号反馈调控枝角类无菌免疫建立血液微生物群平衡
Ping-Ping Liu,Meng Zhang,Zhe Wei et al.
Ping-Ping Liu et al.
A balanced immune response is required to limit the microbes without causing damage to the host. The forkhead box O (FoxO)-mediated immunity plays a pivotal role in maintaining microbiota homeostasis by regulating the expression of antimicr...
Distinct prion conformers from brain and peripheral tissues of gene-targeted mice produce convergent CWD strain properties [0.03%]
来自基因靶向型小鼠脑部和外周组织的不同的朊病毒构象体形成会收敛出CWD毒株的特征
Joseph P DeFranco,Zoe N Atkinson,Jenna Crowell et al.
Joseph P DeFranco et al.
Prions are unique infectious agents because different conformational properties of their constituent proteins are responsible for the manifestation of distinct strains. While prion replication in humans with sporadic Creutzfeldt-Jakob disea...
Culture-specific transcriptional drifts limit the fidelity of organoid infection models [0.03%]
特定于文化的转录漂移限制了类器官感染模型的准确性
Paula E Schweizer,Wisal A Elmagzoub,Sanaa M Idris et al.
Paula E Schweizer et al.
Intestinal organoids are powerful tools for modeling host-pathogen interactions, yet culture-induced artifacts remain poorly defined. Here, we performed time-course transcriptomic profiling of patient-derived ileal organoids microinjected w...
Retraction: Androgen receptor transactivates KSHV noncoding RNA PAN to promote lytic replication-mediated oncogenesis: A mechanism of sex disparity in KS [0.03%]
撤稿：雄激素受体转激活KSHV非编码RNA PAN以促进致瘤性裂解复制：KS性别差异的机制
PLOS Pathogens Editors
PLOS Pathogens Editors
Structural basis for conserved and distinct antigen recognition by a lineage of malaria-protective antibodies [0.03%]
一类具有抗疟保护作用的抗体识别抗原的结构基础
Monika Jain,Fabien Cannac,Sashank Agrawal et al.
Monika Jain et al.
Monoclonal antibodies (mAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) have demonstrated substantial promise in preventing malaria infection and disease. PfCSP is characterized by a central region composed of repe...
ATAD3 megadalton complex in Plasmodium falciparum is essential for mitochondrial and cellular viability [0.03%]
恶性疟原虫ATAD3巨道森氏体复合物对线粒体功能和细胞存活至关重要
Ijeoma C Okoye,Ian M Lamb,Yee-Wai Cheung et al.
Ijeoma C Okoye et al.
Malaria remains an urgent threat to global health as the mortality and infection rates keep rising annually and our frontline antimalarials are becoming less effective due to the emergence and spread of resistance-conferring mutations. Alth...
Fingolimod increases cellular resistance to HIV-1 infection and limits viral reservoir size in peripheral CD4+ T-cells [0.03%]
芬戈莫德可增加细胞对HIV-1感染的抵抗并限制外周CD4+T细胞中病毒库的大小
Elisa Moraga,Núria Climent,Alejandro Sánchez-Molina et al.
Elisa Moraga et al.
Background: Fingolimod, a treatment for multiple sclerosis (MS), decreases autoreactive lymphocytes by lymph node sequestration. In vitro, fingolimod decreases HIV-1 infection and viral reservoir (VR) through SAMHD1 phosp...