Sophia Cangialosi,Jesse L Cimino,Safiehkhatoon Moshkani et al.
Sophia Cangialosi et al.
Major histocompatibility complex class II molecules present exogenous antigen-derived peptide to CD4+ T cells leading to T cell activation as well as signaling into the antigen-presenting cell. Class II is an αβ heterodimer that forms 2 d...
Kaidireya Saimaier,Ling Xie,Chun Wang et al.
Kaidireya Saimaier et al.
A large body of evidence indicates that Th17 cells play essential roles in mucosal immune responses and trigger autoimmune diseases, including multiple sclerosis, inflammatory bowel disease, and psoriasis. Targeting Th17 cells holds promise...
Cellular composition of tissue-resident monocyte-lineage cells reveals transcriptional heterogeneity during inflammatory arthritis [0.03%]
Yidan Wang,Samuel D Dowling,Jessica Maciuch et al.
Yidan Wang et al.
Tissue-resident monocyte-lineage cells (TRMCs) are an extravascular population distinct from circulating monocytes and synovial macrophages and are critical for the development of inflammatory arthritis. However, the precise identities and ...
Thymus engraftment and developmental progression of adoptively transferred progenitor T cells are affected by host conditioning [0.03%]
Yue Ru Li,Christina R Lee,Mahmood Mohtashami et al.
Yue Ru Li et al.
Hematopoietic stem cell transplantation as treatment for patients with leukemia relies on chemotherapy and/or irradiation-based conditioning regimens to prevent graft rejection and cancer relapse. Despite advances in radiotherapy, total bod...
Nikita Trivedi,Nathan D Camp,Rene Yu-Hong Cheng et al.
Nikita Trivedi et al.
Plasma cells (PCs) are terminally differentiated B cells that are long-lived and have high rates of protein secretion. Because of these features, ex vivo generated PCs are being developed as therapeutics for long-term protein delivery. Here...
GLUT1-mediated glucose flux constrains autoreactive but not foreign antigen-specific B-cell responses [0.03%]
GLUT1介导的葡萄糖通路限制自身反应性但不影响外来抗原特异性B细胞免疫应答
Yanan Zhu,Seung Chul Choi,Mark J Shlomchik et al.
Yanan Zhu et al.
Emerging evidence from lupus-prone mice and patients with systemic lupus erythematosus implicates enhanced glycolysis in lymphocytes as a driver of disease. We previously showed that the pharmacologic blockade of glycolysis reduced the prod...
Role of Ca2+-activated KCa3.1 potassium channel in CAR T cell effector function [0.03%]
钙离子激活的KCa3.1钾通道在CAR-T细胞效应功能中的作用
Vivien Jusztus,Márton Hajdu,Péter Horváth et al.
Vivien Jusztus et al.
Genetically modified chimeric antigen receptor (CAR) T cells eliminate tumors by recognizing specific antigens on the cell surface. T cell ion channels (e.g. Kv1.3, KCa3.1) influence activation, proliferation, and effector functions such as...
Elisabeth Jäger,Sana Ismaeel,Christian Stehlik et al.
Elisabeth Jäger et al.
The innate immune system has evolved as the primary response mechanism against microbial infections, tissue damage, and cellular stress. Signals that disrupt homeostasis are sensed by pattern recognition receptors and initiate innate immune...
The influence of nuclear antigen form on complement activation by systemic lupus erythematosus antinuclear antibody immune complexes determined by a novel immunocapture assay [0.03%]
一种新型免疫捕获法测定系统性红斑狼疮抗核抗体免疫复合物补体激活受核抗原形式影响的机制研究
Sanjay Khandelwal,Jonah Chen,Sooho S Myoung et al.
Sanjay Khandelwal et al.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease in which immune complexes (ICs) consisting of antinuclear autoantibodies (ANAs) and nuclear antigens induce complement activation and contribute to disease pathogenesis. Th...
Lactate conditioning reprograms mucosal-associated invariant T cell metabolism boosting effector function [0.03%]
乳酸调节重构黏膜相关不变T细胞代谢以增强效应功能
Ardena Berisha,Benjamin J Jenkins,Nidhi Kedia-Mehta et al.
Ardena Berisha et al.
Mucosal-associated invariant T (MAIT) cells are unconventional T cells, which upon activation can display potent cytotoxic and cytokine-producing capabilities. Together, these features make MAIT cells promising candidates for cancer immunot...