KDM4A promotes microglial pyroptosis and neuropathic pain via the MEG3/SMURF2/HES1 axis [0.03%]
KDM4A通过MEG3/SMURF2/HES1轴促进小胶质细胞焦亡和神经病理性疼痛
Na Wang,Shihua Yu,Lixia Chen et al.
Na Wang et al.
Neuropathic pain (NP) is a refractory clinical disorder in which microglial pyroptosis plays a crucial role, yet the epigenetic regulation by lysine demethylase 4A (KDM4A) remains unclear. In this study, chronic constriction injury (CCI) ra...
Age-related changes in the human T cell receptor alpha repertoire suggest positive selection of dual-specific T cells [0.03%]
与年龄相关的T细胞受体α库的改变表明了双重特异性T细胞的选择性优势
Juho Nummelin,Joonatan Mattila,Vera Middelkamp et al.
Juho Nummelin et al.
The human T cell receptor (TCR) repertoire is generated in the thymus through a process of recombination involving two gene loci, TRA and TRB, and the pairing of the resulting peptide chains. Because of the lack of allelic exclusion in TRA ...
Recombinant SpTrf proteins illustrate putative functions of native SpTrf proteins: from immune response to resolution in sea urchins [0.03%]
重组的SpTrf蛋白质说明了海胆中天然SpTrf蛋白质的假定功能：从免疫反应到解决办法
Ryley S Crow,Christopher Grubb,Joseph W Meisel et al.
Ryley S Crow et al.
The complex and sophisticated sea urchin innate immune system relies on conserved immune receptor and effector molecules plus the euechinoid-specific Transformer family. Native SpTransformer (natSpTrf) proteins in Strongylocentrotus purpura...
CD55 downregulation identifies a pathogenic CD4+ T cell axis linked to p38 MAPK signaling in rheumatoid arthritis [0.03%]
CD55表达下调鉴别出类风湿关节炎中一条与p38MAPK信号传导相联系的致病性CD4+T细胞轴
Ayibaota Bahabayi,Yiming Gao,Ziqi Xiong et al.
Ayibaota Bahabayi et al.
CD4+ T cell dysfunction plays a critical role in the pathogenesis of rheumatoid arthritis (RA). In this study, we investigated the expression, phenotypic characteristics, and potential clinical significance of CD55, a membrane-bound complem...
PD-L1 restrains T-cell immunity in Nile tilapia by suppressing activation-induced fatty acid synthesis [0.03%]
PD-L1通过抑制激活诱导的脂肪酸生物合成限制尼罗罗非鱼T细胞免疫
Jiansong Zhang,Kunming Li,Yuqing Yang et al.
Jiansong Zhang et al.
The programmed death ligand 1/programmed cell death 1 (PD-L1/PD-1) serves as a critical immune checkpoint in T cell-mediated immune responses, playing a central role in maintaining peripheral immune tolerance and homeostasis. Although early...
Immunotherapy of malignant melanoma using T cell-activating microbeads [0.03%]
应用T细胞激活微珠治疗恶性黑色素瘤免疫疗法
Nada T Hassan,Jessica Löffler,Annika Sachs Dos Santos et al.
Nada T Hassan et al.
Metastatic disease is the prime cause of death from many malignancies. Due to the multiple different lesions and the increased aggressiveness of the cancer cells, metastatic disease is often difficult to treat. Here, the introduction of imm...
Isotype-specific antibody secreting plasma cells harbor epigenetic and transcription factor architectures defining distinct cell lineages [0.03%]
特定类型的生发中心B细胞分化成为特定同种型浆细胞的表观遗传调控机制研究
Lou-Ella M M George-Alexander,Roshni Roy,Sakeenah L Hicks et al.
Lou-Ella M M George-Alexander et al.
Antibody-secreting cells (ASCs) are critical effectors of humoral immunity, wherein their distinct isotypes play specialized roles in pathogen defense. Despite studies defining the transcriptional programs of selected ASC isotypes, specific...
Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4+ T cell responses [0.03%]
一种新型MHC-II四聚体的产生和表征用于追踪和表征毒素B特异性CD4+T细胞反应
Jeffrey R Maslanka,Qianxuan She,Kathleen S Krauss et al.
Jeffrey R Maslanka et al.
The gastrointestinal pathogen Clostridioides difficile is a major burden for health systems due to high rates of recurrence. C. difficile pathogenesis is mediated by two virulence factors, toxin A (TcdA) and toxin B (TcdB). Antibodies speci...
Skullcapflavone II alleviates osteoarthritis by inhibiting inflammation and ferroptosis via the SLC7A11/GPX4 signaling pathway [0.03%]
skullcapflavone II通过SLC7A11/GPX4信号通路抑制炎症和铁死亡从而缓解骨关节炎
Jianing Lu,Yijun Lian,Qingchao Ru et al.
Jianing Lu et al.
Osteoarthritis (OA), the most prevalent degenerative joint disease, leads to significant disability in the elderly and is characterized by functional and structural deterioration of the knee joint. This study aimed to investigate the therap...
Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts [0.03%]
c-Myc与谷氨酰胺利用之间的代谢交叉谈话维系了有鳍类动物中IgM+B细胞免疫机能
Xinying Jiao,Yating Zhu,Kang Li et al.
Xinying Jiao et al.
B-cell responses rely on a tightly coordinated interplay between transcriptional programs and metabolic reprogramming. Upon activation, B cells remodel their metabolic profiles, with enhanced glutamine metabolism supporting biomass synthesi...