Skullcapflavone II alleviates osteoarthritis by inhibiting inflammation and ferroptosis via the SLC7A11/GPX4 signaling pathway [0.03%]
skullcapflavone II通过SLC7A11/GPX4信号通路抑制炎症和铁死亡从而缓解骨关节炎
Jianing Lu,Yijun Lian,Qingchao Ru et al.
Jianing Lu et al.
Osteoarthritis (OA), the most prevalent degenerative joint disease, leads to significant disability in the elderly and is characterized by functional and structural deterioration of the knee joint. This study aimed to investigate the therap...
Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts [0.03%]
c-Myc与谷氨酰胺利用之间的代谢交叉谈话维系了有鳍类动物中IgM+B细胞免疫机能
Xinying Jiao,Yating Zhu,Kang Li et al.
Xinying Jiao et al.
B-cell responses rely on a tightly coordinated interplay between transcriptional programs and metabolic reprogramming. Upon activation, B cells remodel their metabolic profiles, with enhanced glutamine metabolism supporting biomass synthesi...
The CXCL10/CXCR3 axis drives actin remodeling to recruit CD4+ T cells to gut epithelium during transmissible gastroenteritis virus infection [0.03%]
CXCL10/CXCR3信号轴在传染性胃肠炎病毒感染期间招募CD4⁺T细胞至肠道上皮细胞中诱导肌动蛋白重塑
Chen Tan,Jianing Chen,Yifei Cai et al.
Chen Tan et al.
The immune system initially protects hosts against viral pathogens, with chemokines guiding immune cell movement. However, their expression patterns and immune cell recruitment mechanisms during transmissible gastroenteritis virus (TGEV) in...
Xiaoxuan Ge,Matthew R Stoner,Joshua A Weiner et al.
Xiaoxuan Ge et al.
Golden hamster (Mesocricetus auratus) and ferret (Mustela putorius furo) are important animal models in studies of human infectious disease. They are used widely to investigate pathogen-spreading mechanisms and host immunology to evaluate t...
Delivery of extracellular vesicle-associated microRNA-146a regulates human monocyte phenotype and function [0.03%]
外泌体相关微小核糖核酸-146a的递送调节人单核细胞表型和功能
Kyle I Mentkowski,Touba Tarvirdizadeh,Rohan Pandey et al.
Kyle I Mentkowski et al.
CCR2+ monocytes are recruited to sites of acute myocardial injury, where they play a critical role in clearing necrotic debris and replenishing the depleted resident macrophage population. Although this response is necessary for early tissu...
Identifying molecular signatures underpinning treatment responses to novel therapeutics influencing COVID-19 outcomes [0.03%]
识别新型疗法影响新冠肺炎转归的治疗反应分子特征
Jodie Ackland,Victor Barozi,Rebekah Penrice-Randal et al.
Jodie Ackland et al.
COVID-19 continues to present ongoing global health challenges driven by diverse immune responses and heterogeneous clinical outcomes. The ACCORD trial evaluated 3 investigational treatments-bemcentinib, tozorakimab, and zilucoplan-in patie...
Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis [0.03%]
SNX5缺乏通过损害MHC II类抗原递呈和炎症反应来促进结核病发展
Beatriz R S Dias,Kubra F Naqvi,Victoria A Ektnitphong et al.
Beatriz R S Dias et al.
Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, yet the host pathways that regulate antigen presentation and lung inflammation during Mycobacterium tuberculosis (Mtb) infection are inco...
Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion [0.03%]
提高治疗性CD4+T细胞的mTORC1活性可促进其持久性但最终会导致耗竭现象
Francesca Sillito,Elisa Armbrecht,Aideen T O&#x;Neill et al.
Francesca Sillito et al.
There is substantial interest in developing novel engineering strategies to promote the sustained metabolic fitness of therapeutic T cells. We previously showed that overexpression of RAS homologue enriched in brain (RHEB), a positive regul...
Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation [0.03%]
鉴定出Arid5a的一个调节别构位点揭露了治疗全身性炎症的治疗轴心
Hamza Hanieh,Hozaifa Metwally,Tadamitsu Kishimoto
Hamza Hanieh
Adenine-thymine (AT)-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) that post-transcriptionally stabilizes mRNAs encoding proinflammatory mediators, including Interleukin-6 (IL-6), thereby amplifying ...
Fluid shear stress as a co-stimulatory cue to enhance T cell priming and restore activation in cancer patient T cells [0.03%]
流体剪切应力通过共刺激方式增强T细胞活化并改善癌症患者T细胞的激活能力
Nicole S Sarna,Monika Antunovic,Paula J Hurley et al.
Nicole S Sarna et al.
Cancer patient-derived T cells often exhibit impaired activation and functional responsiveness due to chronic antigen exposure and therapy-induced immune dysregulation, limiting the efficacy of current immunotherapies. Mechanical forces, su...