CARD9 orchestrates tissue damage in APAP-induced hepatitis via TREM2-mediated sensing cell death [0.03%]
CARD9通过TREM2介导的细胞死亡感知在APAP诱导的肝炎中协调组织损伤
Zaopeng Yang,Shiqi Li,Renlin Lu et al.
Zaopeng Yang et al.
During the progression of acetaminophen (N-acetyl-para-aminophenol [APAP])-induced liver injury, the innate immune response is implicated in the induction of tissue damage. However, the precise cellular and molecular mechanisms underlying t...
Dual regulation of coronin-1 expression by the core promoter and intronic regions [0.03%]
冠状蛋白-1表达的启动子和内含子共同调节作用
Yusuke Ando,Hideyuki Takeshima,Shinya Hasegawa et al.
Yusuke Ando et al.
Coronin family proteins are involved in various cellular processes, such as actin cytoskeleton reorganization, cell motility, and vesicular trafficking. Coronin-1, encoded by Coro1a, is specifically expressed in immune cells, and its defect...
Altered B cell metabolic pathways characterize type 1 diabetes progression [0.03%]
I型糖尿病发展的B细胞代谢途径改变
Holly Conway,Jessica Bernard,Rachel Ramos et al.
Holly Conway et al.
Type 1 diabetes (T1D) results from immune-mediated destruction of pancreatic beta cells. B cells serve as critical antigen-presenting cells whose autoreactive specificities drive disease progression. Conversely, IL-10 producing regulatory B...
Vimentin recognizes African swine fever virus genomic DNA and triggers inflammatory responses by activation of NLRP3 inflammasome [0.03%]
波形蛋白识别非洲猪瘟病毒基因组DNA并通过激活NLRP3炎性小体触发炎症反应
Jie Song,Li Kang,Shijun Zhou et al.
Jie Song et al.
Previous studies have reported that African swine fever virus (ASFV) infection can induce inflammatory responses through the activation of the NLRP3 inflammasome, resulting in the release of IL-1β and the cleavage of gasdermin D. However, ...
Highly efficient and low-cost single-cell culture platform for unbiased analysis of human memory B cell repertoire and antibody discovery [0.03%]
高效且低成本的人类记忆B细胞库及单抗发现单细胞培养平台
Luciana Conde,Debora L Oliveira,Gabriela Maciel et al.
Luciana Conde et al.
The SARS-CoV-2 pandemic underscored the need for innovative approaches to study humoral immunity and isolate monoclonal antibodies (mAbs) with diagnostic and therapeutic potential. Current methods for repertoire analysis at the clonal level...
Negative regulation of a new collectin-11/calreticulin-mediated NF-κB pathway by miR-194b-3p in antibacterial immunity of Takifugu obscurus [0.03%]
微藻194b-3P通过新的 Collectin-11/腔内蛋白TAKW02657.1 介导的 NF-κB信号通路负调控抗菌免疫
Ying Huang,Rui Shen,Hao Wu et al.
Ying Huang et al.
The innate immune system of teleost fish, such as Takifugu obscurus, depends on pattern recognition receptors to detect microbes and mount immune responses. In this study, a new collectin gene was identified in T. obscurus, designated ToCL-...
SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport [0.03%]
SLC7A5独立于亮氨酸转运调节B细胞代谢和浆细胞分化
Anthony Y Tao,Ke Hu,Lucile Noyer et al.
Anthony Y Tao et al.
B cells play critical roles in humoral immunity to infection, vaccination, and autoimmunity. The differentiation of B cells into antibody-producing plasma cells (PCs) has been extensively studied, but the role of metabolic transporters that...
Recombinant human soluble thrombomodulin prevents murine sclerodermatous chronic graft-versus-host disease [0.03%]
重组人可溶性血栓调节蛋白可预防小鼠硬化性慢性移植物抗宿主病
Toshihiro Fujiki,Ryosei Nishimura,Katsuaki Sato et al.
Toshihiro Fujiki et al.
Chronic graft-versus-host disease (cGVHD) develops with complex interactions between immune cells and cytokines, leading to irreversible fibrosis. Severe cGVHD impairs quality of life and is associated with nonrelapse mortality; however, ef...
Tissue signatures of human macrophages during homeostasis and activation [0.03%]
人类巨噬细胞在稳态和激活过程中的组织标志物
Daniel P Caron,William L Specht,Siddhi Nargund et al.
Daniel P Caron et al.
Human macrophages (MΦs) reside in tissues and develop tissue-specific identities. While studies in mice have identified molecular signatures for site-specific MΦ differentiation, less is known about the transcriptional profiles of human M...
Maternal proteome profiling reveals dynamic gestational age-specific responses to de novo vaccination [0.03%]
母体蛋白质组分析揭示了妊娠期特异性新生疫苗接种的动态反应
Paola A Lopez Zapana,Lydia L Shook,Brian A Joughin et al.
Paola A Lopez Zapana et al.
Pregnancy is characterized by dynamic immunological adaptations which are essential for maintaining both maternal and fetal health. The first-time use of coronavirus disease 2019 (COVID-19) vaccines in pregnant individuals presented an oppo...