CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex-driven chromatin remodeling [0.03%]
DUSP2通过BAF介导的染色质重塑表观遗传调控CD8+t细胞效应分化
Emilia R Dellacecca,Jacob B Hirdler,Whitney Barham et al.
Emilia R Dellacecca et al.
Effector gene expression in CD8+ T cells is tightly controlled at the epigenetic and transcriptional levels; however, crucial regulatory signals remain incompletely understood. In this study, we identify dual specificity phosphatase 2 (DUSP...
NKp44 recognition of platelet-derived growth factor D enhances the cytolytic activity of natural killer cells [0.03%]
Nkp44识别血小板源性生长因子D可增强自然杀伤细胞的胞毒活性
Alexander J Sedgwick,Md Abdullah Al Kamran Khan,Nazanin Ghazanfari et al.
Alexander J Sedgwick et al.
Natural killer (NK) cells are cytotoxic innate lymphoid cells that play a critical role in tumor surveillance by releasing proinflammatory cytokines and cytotoxic granules. NKp44 is an activating receptor that promotes NK cell secretion of ...
Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A [0.03%]
死亡受体3(DR3)与其天然配体TL1A独立地与胞内衔接蛋白TRADD和TRAF2相互作用
Weiyong Sun,Bryce G Johnson,Praveen K Veerasubramanian et al.
Weiyong Sun et al.
The TNF‑like cytokine TL1A is a key regulator of immune responses through engagement of its receptor, death receptor 3 (DR3), and has emerged as a therapeutic target in inflammatory diseases. Prevailing models propose that TL1A binding ini...
Distinct kinetic features of innate and adaptive responses in influenza A versus influenza B-infected mice [0.03%]
甲型流感和乙型流感感染小鼠的先天性和适应性免疫反应的不同动力学特征
Sean A Nelson,Ajitanuj Rattan,Bindumadhav Marathe et al.
Sean A Nelson et al.
Influenza B infection is an important source of morbidity and mortality, especially in vulnerable populations such as children. Improved vaccines and antiviral therapeutics are hindered by gaps in knowledge about influenza B viruses (IBVs)....
Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin [0.03%]
人髓系细胞的瘦素分裂免疫调节作用：IDO1在拮抗瘦素免疫刺激作用中的关键作用
Bowen Dong,Spencer Rosario,Wei Luo et al.
Bowen Dong et al.
Obesity increases cancer incidence and aggressiveness but is paradoxically associated with improved response to immunotherapy. Here, we show that intratumoral levels of leptin (LEP), a factor contributing to the development of obesity, pred...
NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis [0.03%]
NAD+消耗将代谢压力与先天免疫启动及选择性控制PANoptosis相联系
Roman Sarkar,Nagakannan Pandian,Balamurugan Sundaram et al.
Roman Sarkar et al.
The innate immune system can detect infection, tissue damage, and other homeostatic disruptions to initiate an immune response, drive inflammation, and promote programmed cell death. While these responses can be beneficial in host defense, ...
Immunosuppressive effects of voclosporin in inflammatory bowel disease through targeted inhibition of SLP-76 and metabolic reprogramming [0.03%]
伏西普利通过靶向抑制SLP-76和代谢重编程在炎症性肠病中的免疫抑制作用
Laura Loges,Michael Gabel,Annkathrin Knauss et al.
Laura Loges et al.
The adaptor protein SLP-76 plays a critical role in T-cell receptor signaling and immune activation, yet its relevance in inflammatory bowel disease (IBD) remains unclear. Although calcineurin inhibitors such as cyclosporine A (CsA) are use...
Platelets are essential for survival of respiratory-restricted viral infection [0.03%]
血小板对呼吸限制性病毒感染的生存至关重要
Iluja Gautam,Chadwick W Huss,Malik Sarsour et al.
Iluja Gautam et al.
Platelets are small, anucleate cells derived from megakaryocytes and are known for their essential role in hemostasis. Over the past decade, they have also emerged as important immune modulators, able to affect viral replication and leukocy...
Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation [0.03%]
造血细胞移植后供体GATA3基因对肠道病原T细胞效应功能和肠嗜酸性粒细胞增多至关重要
Franklin J Yeo,Mengbo Wang,Sungtae Park et al.
Franklin J Yeo et al.
Hematopoietic cell transplantation (HCT) is a curative immunotherapy for hematologic malignancies such as acute myeloid leukemia, primarily through graft-versus-tumor (GVT) effects mediated by donor T cells. However, up to 60% of recipients...
Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function [0.03%]
氨基酸序列的系统发生分析表明跨膜结构域结构元件在MHC II类分子功能中起重要作用
Konstantina Karathanou,Jamie L Duke,Sophia M Cangialosi et al.
Konstantina Karathanou et al.
Human leukocyte antigen class II genes are highly polymorphic. This raises the question of how polymorphisms are distributed across the entirety of the class II molecule and how this distribution affects function. We performed a comprehensi...