Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice [0.03%]
脑源性神经营养因子过度表达小鼠工作记忆缺失、焦虑样行为增加和易惊厥性增强
Francesco Papaleo,Jill L Silverman,Jordan Aney et al.
Francesco Papaleo et al.
BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparin...
Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats [0.03%]
杏仁体内注射ZIP影响大鼠习得性积极回避反应和削弱条件性味觉厌恶学习
Fernando Gámiz,Milagros Gallo
Fernando Gámiz
We have investigated the effect of protein kinase Mzeta (PKMζ) inhibition in the basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats. ZIP ...
Associative retrieval processes in the human medial temporal lobe: hippocampal retrieval success and CA1 mismatch detection [0.03%]
人脑内侧颞叶联想检索过程：海马检索成功和CA1差异检测
Janice Chen,Rosanna K Olsen,Alison R Preston et al.
Janice Chen et al.
Hippocampal subfields CA(3) and CA(1) are hypothesized to differentially support the generation of associative predictions and the detection of associative mismatches, respectively. Using high-resolution functional MRI, we examined hippocam...
From humans to rats and back again: bridging the divide between human and animal studies of recognition memory with receiver operating characteristics [0.03%]
从人类到大鼠再回到人类：用接受者操作特性曲线连接人和动物识别记忆研究之间的差异
Joshua D Koen,Andrew P Yonelinas
Joshua D Koen
Receiver operating characteristics (ROCs) have been used extensively to study the processes underlying human recognition memory, and this method has recently been applied in studies of rats. However, the extent to which the results from hum...
Extinction after retrieval: effects on the associative and nonassociative components of remote contextual fear memory [0.03%]
提取后的消亡：对遥远的情境恐惧记忆的联结和非联结成分的影响
Marco Costanzi,Sara Cannas,Daniele Saraulli et al.
Marco Costanzi et al.
Long-lasting memories of adverse experiences are essential for individuals' survival but are also involved, in the form of recurrent recollections of the traumatic experience, in the aetiology of anxiety diseases (e.g., post-traumatic stres...
β-Adrenergic receptors in the insular cortex are differentially involved in aversive vs. incidental context memory formation [0.03%]
杏仁核皮质中的β肾上腺素受体在aversive和意外的情境记忆形成中所起的作用不同
María Isabel Miranda,Elizabeth Sabath,Luis Nuñez-Jaramillo et al.
María Isabel Miranda et al.
The goal of this research was to determine the effects of β-adrenergic antagonism in the IC before or after inhibitory avoidance (IA) training or context pre-exposure in a latent inhibition protocol. Pretraining intra-IC infusion of the β...
Jonathan Weng-Thim Ho,Katherine Elizabeth Narduzzo,Alexandra Outram et al.
Jonathan Weng-Thim Ho et al.
Ablations and local intracerebral infusions were used to determine the role of rat temporal association cortex (area Te2) in object recognition memory, so that this role might be compared with that of the adjacent perirhinal cortex (PRH). B...
Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex [0.03%]
顶叶皮层胆碱能拮抗产生的物体识别记忆损伤的不同时间依赖性
Chris J Tinsley,Nadine S Fontaine-Palmer,Maria Vincent et al.
Chris J Tinsley et al.
The roles of muscarinic and nicotinic cholinergic receptors in perirhinal cortex in object recognition memory were compared. Rats' discrimination of a novel object preference test (NOP) test was measured after either systemic or local infus...
Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling [0.03%]
多巴胺信号在经典激励动机和操作性激励学习过程中的不同依赖性
Kate M Wassum,Sean B Ostlund,Bernard W Balleine et al.
Kate M Wassum et al.
Here we attempted to clarify the role of dopamine signaling in reward seeking. In Experiment 1, we assessed the effects of the dopamine D(1)/D(2) receptor antagonist flupenthixol (0.5 mg/kg i.p.) on Pavlovian incentive motivation and found ...
Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning [0.03%]
纹状体神经元选择性失活腺苷A2A受体可增强工作记忆和逆转学习能力
Catherine J Wei,Philipp Singer,Joana Coelho et al.
Catherine J Wei et al.
The adenosine A(2A) receptor (A(2A)R) is highly enriched in the striatum where it is uniquely positioned to integrate dopaminergic, glutamatergic, and other signals to modulate cognition. Although previous studies support the hypothesis tha...