Maintenance of memory by negative feedback of synaptic protein elimination: modeling KIBRA-PKMζ dynamics in LTP [0.03%]
通过抑制性反馈维持记忆：KIBRA-PKMζ在长时程增强中的动态模型
Harel Z Shouval,Changchi Hsieh,Rafael E Flores-Obando et al.
Harel Z Shouval et al.
Long-term activity-dependent modifications of synaptic strength are a cellular substrate of learning and memory, but how long-lasting memory could be based on synaptic proteins that rapidly degrade and diffuse is unknown. Most current theor...
Medial orbitofrontal cortex activation reduces discrimination for threat in male rats [0.03%]
中隔 Orbitofrontal 大脑皮层激活可降低雄性大鼠对威胁的识别能力
Jia-Zhen Shih,Chang-Chih Kuo
Jia-Zhen Shih
Recognizing threats is crucial for animals to adopt appropriate behaviors. The orbitofrontal cortex (OFC) is essential for emotional regulation and cognitive flexibility. This study investigated the effect of medial OFC (mOFC) manipulation ...
Prospective and concurrent metamemory of familiarity and working memory by rhesus monkeys [0.03%]
猕猴对熟悉感和工作记忆的预期元认知和并发元认知
Jad Nasrini,Tara Dove-VanWormer,Robert R Hampton
Jad Nasrini
Monkeys sometimes accurately predict their memory accuracy, a form of metamemory. The memory signals that support this ability may differ between memory systems and depend on when memory judgments are made. Working memory requires active ma...
Differential impacts of advanced age and sex in age-related trace fear memory impairment in rats [0.03%]
衰老和性别在大鼠年龄相关痕迹恐惧记忆损伤中的不同影响
Payton K Robinson,Timothy J Jarome,Sydney Trask
Payton K Robinson
While cognitive function remains stable for majority of the lifespan, many functions sharply decline in later life. Women have higher rates of neurodegenerative diseases that involve memory loss, including Alzheimer's disease. This sex disp...
Sex and estrous cycle effects on stress-enhanced fear learning in Long-Evans rats [0.03%]
大鼠应激增强恐惧记忆的性别和发情周期影响研究
Sofia A Lopez-Kawa,K Matthew Lattal
Sofia A Lopez-Kawa
Individuals diagnosed with post-traumatic stress disorder (PTSD) are hyperresponsive to otherwise ordinary stimuli (e.g., loud noises or certain smells) long after a traumatic experience. At a preclinical level, this persistent effect of tr...
Reward responsiveness (BAS) facilitates contingency awareness in appetitive conditioning [0.03%]
奖励敏感性（BAS）在诱发条件反射中促进连锁反应意识
Johannes B Finke,Tim Klucken
Johannes B Finke
Individual differences in reinforcement sensitivity may shape associative learning processes. We investigated how behavioral inhibition and activation systems (BIS/BAS), that is, variation in avoidance versus approach tendencies, modulate a...
Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory [0.03%]
成年大鼠多重情境辨别中的性别差异及厌恶记忆的时间依赖性泛化的动态变化
Fernanda Nogueira Lotz,Kétlyn Talise Knak Guerra,Ana Paula Crestani et al.
Fernanda Nogueira Lotz et al.
Memory generalization involves the transfer of conditioned fear responses to novel contexts, a phenomenon observed in systems consolidation, whereby a time-dependent reduction in discrimination precision occurs due to the reorganization of ...
Robust renewal after extinction of remotely acquired Pavlovian conditioning [0.03%]
远距离获得的经典条件作用消退后的稳健更新
Joseph W Charles,Samantha K Moriarty,Danielle I Fournier et al.
Joseph W Charles et al.
Extinguished responses are prone to renew outside the context where extinction occurred. Two experiments compared extinction and renewal following either a 1 day conditioning-to-extinction interval or a 27 day interval. Rats received tone-s...
Individual contribution of PDE4B and PDE4D subfamilies to the prevention of object location memory impairments induced by sleep deprivation [0.03%]
PDE4B和PDE4D亚家族分别对于睡眠剥夺引起的物体位置记忆缺损的预防作用
Hongyu Zhao,Arjan Blokland,Jos Prickaerts et al.
Hongyu Zhao et al.
Insufficient sleep compromises the cAMP signaling pathway in the hippocampus, negatively impacting hippocampus-dependent memory. In the current study, we explored whether selective PDE4B or selective PDE4D inhibition can improve hippocampus...
Weizhen Xie,Susan G Wardle,Jenna Langbein et al.
Weizhen Xie et al.
Classic models propose that forming lasting visual memories involves coordinated interactions between visually selective neocortical structures and the hippocampus during memory consolidation. However, the precise role of visually selective...