Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine [0.03%]
唐氏综合征小鼠模型中夸大存在的NMDA受体介导的长时程抑制及其用美金刚的药理学干预
Jonah J Scott-McKean,Alberto C S Costa
Jonah J Scott-McKean
The Ts65Dn mouse is the best-studied animal model for Down syndrome. In the experiments described here, NMDA-mediated or mGluR-mediated LTD was induced in the CA1 region of hippocampal slices from Ts65Dn and euploid control mice by bath app...
Bidirectional plasticity in striatonigral synapses: a switch to balance direct and indirect basal ganglia pathways [0.03%]
纹状体黑质突触的双向可塑性：直接通路和间接通路平衡转换的开关机制
Jose J Aceves,Pavel E Rueda-Orozco,Ricardo Hernandez-Martinez et al.
Jose J Aceves et al.
There is no hypothesis to explain how direct and indirect basal ganglia (BG) pathways interact to reach a balance during the learning of motor procedures. Both pathways converge in the substantia nigra pars reticulata (SNr) carrying the res...
Nicole Ertman,Joseph M Andreano,Larry Cahill
Nicole Ertman
Significant sex differences in the well-documented relationship between stress hormones and memory have emerged in recent studies. The potentiating effects of glucocorticoids on memory vary across the menstrual cycle, suggesting a potential...
Anterior thalamic lesions alter both hippocampal-dependent behavior and hippocampal acetylcholine release in the rat [0.03%]
背侧丘脑前核损伤后大鼠海马介导的行为和乙酰胆碱能神经功能的改变
Lisa M Savage,Joseph M Hall,Ryan P Vetreno
Lisa M Savage
The anterior thalamic nuclei (ATN) are important for learning and memory as damage to this region produces a persistent amnestic syndrome. Dense connections between the ATN and the hippocampus exist, and importantly, damage to the ATN can i...
Brian J Wiltgen,Alynda N Wood,Brynne Levy
Brian J Wiltgen
The N-methyl-D-aspartate receptor (NMDAR) is thought to be essential for synaptic plasticity and learning. However, recent work indicates that the role of this receptor depends on the prior history of the research subject. For example, anim...
Decoding overlapping memories in the medial temporal lobes using high-resolution fMRI [0.03%]
利用高分辨率功能磁共振解码内侧颞叶中的重叠记忆痕迹
Martin J Chadwick,Demis Hassabis,Eleanor A Maguire
Martin J Chadwick
The hippocampus is proposed to process overlapping episodes as discrete memory traces, although direct evidence for this in human episodic memory is scarce. Using green-screen technology we created four highly overlapping movies of everyday...
Average group behavior does not represent individual behavior in classical conditioning of the honeybee [0.03%]
蜜蜂的经典条件反射实验中群体水平的效应不能代表个体水平上的效应
Evren Pamir,Neloy Kumar Chakroborty,Nicola Stollhoff et al.
Evren Pamir et al.
Conditioned behavior as observed during classical conditioning in a group of identically treated animals provides insights into the physiological process of learning and memory formation. However, several studies in vertebrates found a rema...
Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin [0.03%]
蛋白合成抑制剂anisomycin内侧膝状核注射破坏情绪性记忆的巩固
Janine L Kwapis,Timothy J Jarome,Janet C Schiff et al.
Janine L Kwapis et al.
Memory for delay fear conditioning requires the synthesis of new mRNA and protein in the basolateral amygdala. It is currently unknown whether similar molecular processes in the amygdala are required for the formation of trace fear memory, ...
A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where [0.03%]
海马神经元放电模式表征“什么在哪儿发生”的机制研究
Adriano B L Tort,Robert Komorowski,Nancy Kopell et al.
Adriano B L Tort et al.
The association of specific events with the context in which they occur is a fundamental feature of episodic memory. However, the underlying network mechanisms generating what-where associations are poorly understood. Recently we reported t...
Is all motivation good for learning? Dissociable influences of approach and avoidance motivation in declarative memory [0.03%]
所有动机都利于学习吗？趋近性和回避性动机在陈述性记忆中的分离效应
Vishnu P Murty,Kevin S LaBar,Derek A Hamilton et al.
Vishnu P Murty et al.
The present study investigated the effects of approach versus avoidance motivation on declarative learning. Human participants navigated a virtual reality version of the Morris water task, a classic spatial memory paradigm, adapted to permi...
Randomized Controlled Trial
Learning & memory (Cold Spring Harbor, N.Y.). 2011 Oct 21;18(11):712-7. DOI:10.1101/lm.023549.111 2011